A5055481407- Optical Imaging and Spectroscopy Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Spectroscopy Techniques in Biomedical and Chemical Research
- Thermal Regulation in Medicine
- Cardiac Arrest and Resuscitation
- Climate Change and Health Impacts
- Cardiac Health and Mental Health
- High Altitude and Hypoxia
- Management of metastatic bone disease
- Antibiotics Pharmacokinetics and Efficacy
- Heart Rate Variability and Autonomic Control
- Mitochondrial Function and Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal and fetal brain pathology
- Cardiovascular and exercise physiology
- Metabolism and Genetic Disorders
- Photoacoustic and Ultrasonic Imaging
- Spinal Fractures and Fixation Techniques
University College London
2010-2025
University College London Hospitals NHS Foundation Trust
2015-2025
National Hospital for Neurology and Neurosurgery
2010-2016
Royal London Hospital
2010-2016
University College Hospital
2012-2013
The redox state of cerebral mitochondrial cytochrome c oxidase monitored with near-infrared spectroscopy (Δ[oxCCO]) is a signal strong potential as non-invasive, bedside biomarker metabolic status. We hypothesised that the higher density brain compared to skin and skull would lead evidence brain-specificity Δ[oxCCO] when measured multi-distance (NIRS) system. Measurements well concentration changes in oxygenated (Δ[HbO2]) deoxygenated haemoglobin (Δ[HHb]) were taken at multiple...
Using transcranial near-infrared spectroscopy (NIRS) to measure changes in the redox state of cerebral cytochrome c oxidase (Δ[oxCCO]) during functional activation healthy adults is hampered by instrumentation and algorithm issues. This study reports Δ[oxCCO] response measured such a setting investigates possible confounders this measurement. Continuous frontal lobe NIRS measurements were collected from 11 volunteers 6-minute anagram-solving task, using hybrid optical spectrometer (pHOS)...
Continuous monitoring of cerebral autoregulation might provide novel treatment targets and identify therapeutic windows after acute brain injury. Slow oscillations hemodynamics (0.05-0.003 Hz) are visible in multimodal neuromonitoring may be analyzed to novel, surrogate measures autoregulation. Near-infrared spectroscopy (NIRS) is an optical technique, which shows promise for widespread clinical applicability because it noninvasive easily delivered across a wide range scenarios. The aim this...
Abstract Introduction Advancements in cancer treatments are resulting improved prognosis for patients. However, these therapies may cause cardiotoxicity, including left ventricular systolic dysfunction which manifest years later. Echocardiographic monitoring frequency survivors, timing and role of initiation cardioprotective medication to manage asymptomatic mild this cohort is poorly understood. Aims To assess combined cardiopulmonary exercise test stress echo (CPET-SE) providing additional...
Acute brain injury is associated with depressed aerobic metabolism. Below a critical mitochondrial pO 2 cytochrome c oxidase, the terminal electron acceptor in respiratory chain, fails to sustain oxidative phosphorylation. After acute injury, this ischaemic threshold might be shifted into apparently normal levels of tissue oxygenation. We investigated oxygen dependency metabolism 16 acutely brain-injured patients using 120-min normobaric hyperoxia challenge phase (24–72 h) post-injury and...
Transcranial near-infrared spectroscopy (NIRS) provides an assessment of cerebral oxygen metabolism by monitoring concentration changes in oxidised cytochrome c oxidase Δ[oxCCO]. We investigated the response Δ[oxCCO] to global delivery at different source-detector separations 16 healthy adults. Hypoxaemia was induced a hypoxic inspired gas mix and hypercapnia addition 6 % CO2 gases. A hybrid optical spectrometer used measure frontal cortex light absorption scattering discrete wavelengths...
For resolving concentrations of tissue chromophores in the human adult brain with near-infrared spectroscopy it is advantageous to calculate light scattering and absorption, at multiple wavelengths some depth resolution. We report a novel methodology that combines multi-distance frequency broadband spectrometers we show preliminary results healthy young during hypo- hypercapnia.
Cerebral autoregulation (CA) maintains cerebral blood flow over a range of perfusion pressure. Continuous CA monitoring might define pressure targets minimising secondary brain injury, but application is limited by available modalities. Near-infrared spectroscopy (NIRS) noninvasive optical technique characterising aspects CA. The NIRS-derived tissue oxygenation index (TOI) correlated with (BP) to produce an vascular reactivity (TOx) [1]. contribution from extracerebral tissues, complexity...