Joel Salazar‐Mendiguchía
A5040524509- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Viral Infections and Immunology Research
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Congenital heart defects research
- Venous Thromboembolism Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Drug-Induced Ocular Toxicity
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Muscle Physiology and Disorders
- Cardiac Health and Mental Health
- Takotsubo Cardiomyopathy and Associated Phenomena
- Trypanosoma species research and implications
- Transplantation: Methods and Outcomes
- Coronary Artery Anomalies
- Heparin-Induced Thrombocytopenia and Thrombosis
- RNA and protein synthesis mechanisms
- Infectious Encephalopathies and Encephalitis
Bellvitge University Hospital
2012-2025
Hospital Universitario Virgen de la Arrixaca
2024
Instituto de Investigación Biomédica de Málaga
2022
Instituto de Salud Carlos III
2022
Institut d'Investigació Biomédica de Bellvitge
2012-2021
Instituto de Investigación Biomédica de A Coruña
2020-2021
Universitat Autònoma de Barcelona
2017-2020
Universidade da Coruña
2017-2020
Hospital General de Catalunya
2019
Universitat de Barcelona
2012-2017
Alcoholic cardiomyopathy (ACM) is defined by a dilated and impaired left ventricle due to chronic excess alcohol consumption. It largely unknown which factors determine cardiac toxicity on exposure alcohol. This study sought evaluate the role of variation in cardiomyopathy-associated genes pathophysiology ACM, examine effects intake genotype (DCM) severity. The authors characterized 141 ACM cases, 716 DCM 445 healthy volunteers. compared prevalence rare, protein-altering variants 9...
The Cardiomyopathy Registry of the EURObservational Research Programme is a prospective, observational, and multinational registry consecutive patients with four cardiomyopathy subtypes: hypertrophic (HCM), dilated (DCM), arrhythmogenic right ventricular (ARVC), restrictive (RCM). We report baseline characteristics management adults enrolled in registry. A total 3208 were by 69 centres 18 countries [HCM (n = 1739); DCM 1260); ARVC 143); RCM 66)]. Differences between subtypes (P < 0.001)...
The genetic cause of hypertrophic cardiomyopathy remains unexplained in a substantial proportion cases. Formin homology 2 domain containing 3 (FHOD3) may have role the pathogenesis cardiac hypertrophy but has not been implicated cardiomyopathy. This study sought to investigate relation between FHOD3 mutations and development was sequenced by massive parallel sequencing 3,189 unrelated probands 2,777 patients with no evidence (disease control subjects). authors evaluated protein-altering...
The X-linked Danon disease manifests by severe cardiomyopathy, myopathy, and neuropsychiatric problems. We designed this registry to generate a comprehensive picture of clinical presentations outcome patients with in cardiomyopathy centers throughout Europe.Clinical genetic data were collected 16 cardiology from 8 European countries.The cohort comprised 30 male 27 female patients. age at diagnosis was birth 42 years men 2 65 women. Cardiac involvement observed 96%. Extracardiac...
Objective Up to 50% of patients with hypertrophic cardiomyopathy (HCM) show no disease-causing variants in genetic studies. TRIM63 has been suggested as a candidate gene for the development cardiomyopathies, although evidence causative role HCM is limited. We sought investigate relationship between rare and HCM. Methods was sequenced by next generation sequencing 4867 index cases clinical diagnosis 3628 probands other cardiomyopathies. Additionally, 3136 familial cardiovascular diseases than...
Abstract Background Hereditary hemorrhagic telangiectasia (HHT) is a rare vascular disease with autosomal dominant inheritance. Disease-causing variants in endoglin ( ENG ) and activin A receptor type II-like 1 ACVRL1 genes are detected more than 90% of cases submitted to molecular diagnosis. Methods We used data from the RiHHTa (Computerized Registry Hemorrhagic Telangiectasia) registry describe genetic assess their genotype-phenotype correlation among HHT patients Spain. Results By May...
Aortoseptal angulation (AoSA) can predict provocable left ventricular outflow tract obstruction (LVOTO) in patients with symptomatic hypertrophic cardiomyopathy (HCM). Lack of a standardised measurement technique HCM without the need for complex three-dimensional (3D) imaging limits its usefulness routine clinical practice. This study aimed to validate simple AoSA using 2D echocardiography and cardiac MR (CMR) as predictor LVOTO.We retrospectively assessed 160 non-obstructive HCM, referred...
Danon disease (DD) is a rare X‐linked disorder caused by loss‐of‐function mutations in the LAMP2 gene, which encodes lysosome‐associated membrane protein. It characterized triad of hypertrophic cardiomyopathy, myopathy, and intellectual disability. Whereas molecular pathophysiological mechanisms underlying this have been previously reported continue to be explored, cognitive deficits psychiatric comorbidities manifested DD remain an understudied topic. We systematically assessed abilities 13...
Background: We aimed to assess the impact of implementation reperfusion networks, type hospital and specialty treating physician on management outcomes ST segment elevation myocardial infarction in patients aged ⩾75 years. Methods: analysed data from Minimum Basic Data Set Spanish public health system, assessing discharges between 2004 2013. Discharges were distributed three groups depending clinical management: percutaneous coronary intervention, thrombolysis or no reperfusion. Primary...
Percutaneous coronary intervention (PCI) improves prognosis in patients with acute syndromes (ACS) reducing ischaemic complications and the development of heart failure, thus potentially changing invasive mechanical ventilation (IMV) requirements. Little information exists about ACS requiring IMV current era. We aimed to analyze requirements characteristics treated under recommendations (including a high rate PCI). Baseline characteristics, indications for IMV, management in-hospital...
Previous predictive models of bleeding in acute coronary syndromes (ACSs) used different definitions and some them come from populations lacking important predictors haemorrhagic complications. Our group previously developed a model (PMB), including clinically meaningful variables, providing an optimal ability. We aimed to compare the ability this PMB with main available risk scores for predicting major according non-selected ACS patients daily clinical practice. All admitted Coronary Care...