A5022757593- Anorectal Disease Treatments and Outcomes
- Pelvic floor disorders treatments
- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Gastrointestinal motility and disorders
- Advanced Chemical Sensor Technologies
- Colorectal and Anal Carcinomas
- Congenital gastrointestinal and neural anomalies
- Cardiac, Anesthesia and Surgical Outcomes
- Hernia repair and management
- Urinary Bladder and Prostate Research
- Olfactory and Sensory Function Studies
- COVID-19 and healthcare impacts
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Biochemical Analysis and Sensing Techniques
- Intestinal and Peritoneal Adhesions
- Colorectal Cancer Screening and Detection
- Sarcoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Stoma care and complications
- Abdominal Surgery and Complications
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
University of Bari Aldo Moro
2016-2025
Istituto Tumori Bari
2019-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2023
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari
2015-2021
Roche Pharma AG (Germany)
2021
Collaborative Group (United States)
2021
State Scientific Center of Coloproctology
2017
Cleveland Clinic Florida
1997-2017
Inonu University
2017
Azerbaijan Medical University
2017
Abstract Background An effective screening tool for colorectal cancer is still lacking. Analysis of the volatile organic compounds (VOCs) linked to a new frontier in screening, as tumour growth involves several metabolic changes leading production specific that can be detected exhaled breath. This study investigated whether patients with have VOC pattern compared healthy population. Methods Exhaled breath was collected an inert bag (Tedlar®) from and controls (negative at colonoscopy),...
This manuscript summarizes consensus reached by the International Anorectal Physiology Working Group (IAPWG) for performance, terminology used, and interpretation of anorectal function testing including manometry (focused on high-resolution manometry), rectal sensory test, balloon expulsion test. Based these measurements, a classification system disorders is proposed.Twenty-nine working group members (clinicians/academics in field gastroenterology, coloproctology, gastrointestinal...
Abstract Aim The goal of this European Society ColoProctology project was to establish a multidisciplinary, international guideline for haemorrhoidal disease (HD) and provide guidance on the most effective (surgical) treatment patients with HD. Methods development process consisted six phases. In phase one we defined scope guideline. patient population included all stages haemorrhoids. target group practitioners treating haemorrhoids and, in addition, healthcare workers who desired...
Abstract Background The aim of this study was to compare the results conventional open haemorrhoidectomy as currently practised in Italy (group 1) with stapled using a 33-mm circular stapling device 2). Methods One hundred patients symptomatic third- and fourth-degree haemorrhoids were enrolled by five hospitals. Patients allocated two groups according centralized randomization scheme featuring permutated blocks 20. Preoperative clinical examination anorectal manometry demonstrated no...
Abstract Objective There is no objective means to assess the obstructed defaecation syndrome (ODS), allow evaluation of outcome or compare efficacy treatment including surgery. The study aimed validate a disease‐specific index quantify severity assessment results in clinical trials, permit comparison between them. Method Seventy‐six patients with ODS and 30 healthy controls entered after proctologic ano‐rectal physiological investigation. Hirschsprung's disease slow transit constipation were...
Obstructed defecation may be treated by stapled transanal rectal resection, but different complications and recurrence rates have been reported. The present study was designed to evaluate resection results, outcome predictive factors, nature of complications.Clinical functional data 123 patients were retrospectively analyzed. All had symptoms obstructed before surgery rectocele and/or intussusception. Of them, 85 operated on the authors 38 referred after performed elsewhere.At a median...
Sacral nerve stimulation is a safe and effective procedure for fecal incontinence. We investigated whether its efficacy maintained long term.Sixty patients with incontinence underwent permanent sacral stimulation. Patients' data were prospectively recorded in the national registry of Italian Group The severity was evaluated by Wexner score, collected bowel function diary. Quality life version Medical Outcomes Survey Short Form (SF-36) questionnaire.Fifty-two available long-term follow-up...
Abstract Background Sacral nerve stimulation (SNS) has proven short- to medium-term effectiveness for the treatment of faecal incontinence (FI); fewer long-term outcomes have been presented and usually in small series. Here, SNS was evaluated a large European cohort patients with minimum 5 years' follow-up. Methods Prospectively registered data from FI who had received at least years ten centres were collated by survey. Daily stool diaries, Cleveland Clinic St Mark's scores baseline, after...
PURPOSE: Internal anal sphincterotomy for treating chronic fissure can irreversibly damage continence. Reversible chemical may be achieved by application of glyceryl trinitrate ointment (nitric oxide donor), which has been reported to heal the majority patients with inducing sphincter relaxation and improving anodermal blood flow. This trial aimed further clarify role in treatment fissure. METHODS: A total 132 consecutive from nine centers were randomly assigned receive 0.2 percent or...
PURPOSE: There are several options in the treatment of fecal incontinence; it is often difficult to choose most appropriate, adequate treatment. The consolidated experience gained urologic field suggests that sacral nerve stimulation may be a further option choice aim our study was evaluate preliminary results peripheral evaluation test obtained multicenter collaborative on patients with defecatory and urinary disturbances. METHODS: Forty (9 males; mean age, 50.2; range, 26-79 years)...
PURPOSE: Sacral nerve modulation appears to offer a valid treatment option for some patients with fecal incontinence and functional defects of the internal anal sphincter or striated muscle. METHODS: Sixteen (4 males; mean age, 51.4 (range, 27-79) years) intact surgically repaired (n=1) underwent permanent sacral stimulation implant. Cause was traumatic in two patients, associated disorders included scleroderma (2 patients) spastic paraparesis (1 patient); eight (50 percent) also had urinary...
Doppler-guided transanal haemorrhoid dearterialization (THD) and stapler haemorrhoidopexy (SH) have been demonstrated to be less painful than the Milligan-Morgan procedure. The aim of this study was compare effectiveness THD vs SH in treatment third-degree haemorrhoids an equivalent trial.One hundred sixty-nine patients with were randomized online receive (n = 85) or 84) 10 Colorectal Units which staff well trained both techniques. mean follow-up period 17 (range 15-20) months.Early minor...
INTRODUCTION: Altemeier's procedure is infrequently applied in European countries and because of the small number patients treated each center, its long-term reliability uncertain. METHODS: Medical records 93 (median age, 77 years) undergoing perineal rectosigmoidectomy associated with levatorplasty 72 (78 percent) were reviewed; 65 (70 suffered from major fecal incontinence. RESULTS: There was no postoperative mortality. Eight (8.6 complications observed (3 pelvic hematomas, 1 anastomotic...
Abstract Background Effective screening for colorectal cancer can reduce mortality by early detection of tumours and colonic polyps. An altered pattern volatile organic compounds (VOCs) in exhaled breath has been proposed as a potential non-invasive diagnostic tool cancer. The aim this study was to evaluate the reliability breath-testing diagnosis using an advanced sampler. Methods patients with non-cancer controls negative findings on colonoscopy collected ReCIVA® Breath Sampler. This...
A study was undertaken to determine outcome and identify predictors of success for biofeedback constipation.Patients who had at least one session were evaluated whether or not they completed a treatment course. Parameters assessed included use cathartics, number spontaneous bowel movements per week, presence rectal pain, sessions results anorectal physiology.A total 194 patients (59 male, 135 female) median age 71 (range 11-96) years, including 30 with concomitant treated. The week before 0....
Abstract Introduction Stapled haemorrhoidopexy is less painful than Milligan-Morgan haemorrhoidectomy, allowing an earlier return to working activities, but its long-term efficacy not fully established. This study reports the follow-up of a randomized clinical trial comparing two techniques in 100 patients affected by third- and fourth-degree haemorrhoids. Methods All were contacted invited attend clinic assess functional outcome. The degree continence satisfaction assessed questionnaire....
We report a multicentric prospective study which aimed to evaluate Doppler-assisted ligation of the terminal haemorrhoidal arteries (THD) for II and III degree haemorrhoids.A total 112 patients from five colorectal units, including 81 men, mean age 48 +/- 13 years, with (39) (73) haemorrhoids were treated by Doppler-guided transanal de-arterialization anopexy using new device (THD).The operative time was 33.9 8.8 minutes, number ligatures applied 7.2 1.5. Postoperatively, 72% did not need...