A5015071817- Gastrointestinal motility and disorders
- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Gastroesophageal reflux and treatments
- Music Therapy and Health
- Congenital gastrointestinal and neural anomalies
- Acupuncture Treatment Research Studies
- Dysphagia Assessment and Management
- Diverticular Disease and Complications
- Myofascial pain diagnosis and treatment
- Enhanced Recovery After Surgery
- Spinal Dysraphism and Malformations
- Systemic Sclerosis and Related Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Child Nutrition and Feeding Issues
- Spinal Cord Injury Research
- Eosinophilic Esophagitis
- Therapeutic Uses of Natural Elements
- Diet and metabolism studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Medical and Biological Sciences
- Stoma care and complications
- Cancer Treatment and Pharmacology
- Pressure Ulcer Prevention and Management
- Musculoskeletal pain and rehabilitation
Royal North Shore Hospital
2015-2025
The University of Sydney
2015-2025
Northern Sydney Local Health District
2019-2020
North Shore Hospital
2008-2018
AZ Sint-Lucas
2008
Universitair Ziekenhuis Brussel
2008
University Gastroenterology
2008
Mayo Clinic
1997-2000
Mayo Clinic in Florida
1999
WinnMed
1997
This manuscript summarizes consensus reached by the International Anorectal Physiology Working Group (IAPWG) for performance, terminology used, and interpretation of anorectal function testing including manometry (focused on high-resolution manometry), rectal sensory test, balloon expulsion test. Based these measurements, a classification system disorders is proposed.Twenty-nine working group members (clinicians/academics in field gastroenterology, coloproctology, gastrointestinal...
Benign anorectal disorders of structure and function are common in clinical practice. These guidelines summarize the preferred approach to evaluation management defecation disorders, proctalgia syndromes, hemorrhoids, anal fissures, fecal incontinence adults represent official practice recommendations American College Gastroenterology. The scientific evidence for these was assessed using Grading Recommendations Assessment, Development Evaluation process. When not appropriate Evaluation, we...
Faecal incontinence is a common debilitating condition associated with poor quality of life that generates substantial economic strain on healthcare systems.
ABSTRACT Background Anal slow waves (SW) and ultraslow (USW) have been documented previously, yet their significance remains uncertain. Our aims were to characterize the prevalence features of SW USW in healthy subjects patients with constipation correlate them clinical anorectal physiological testing. Methods Forty‐three female 83 tertiary referral included. High‐resolution water‐perfused manometry was performed. Retrospective blinded descriptive quantitative analyses manometric tracings...
To characterize α 2 -adrenergic control of motor and sensory functions gastrointestinal tract colon, we studied dose-related effects clonidine (placebo or up to 0.3 mg po) by random assignment in 55 healthy humans. Gastrointestinal transit was measured all subjects; 35, assessed colonic compliance, tone, sensations gas pain during phasic distensions. Clonidine did not significantly alter transit, but it increased compliance reduced fasting tone without altering response a meal. aggregate...
Previous surveys of gastrointestinal symptoms after spinal cord injury have not used validated questionnaires and focused on the full spectrum such their relationship to factors, as level psychologic dysfunction. This study was designed detail prevalence in determine clinical factors associated with symptoms.Established patients (>12 months) randomly selected from a database completed following three questionnaires: 1) Rome II Integrative Questionnaire, 2) Hospital Anxiety Depression Scale,...
Aliment Pharmacol Ther 2011; 33: 1245–1251 Summary Background Anorectal biofeedback therapy (BFT) is a safe and effective treatment in patients with constipation. Given the high prevalence of constipation therefore demand for BFT, there need to prioritise patients. Aims To explore clinical features anorectal physiology which predict success or failure BFT derive statistical model helps BFT. Methods A total 102 referred were evaluated. All underwent comprehensive function assessment,...
PURPOSE: Although functional constipation is known to often manifest concomitant features of pelvic floor dyssynergia, the nature symptoms and anorectal dysfunction in non-diarrhea predominant irritable bowel syndrome less clear. This study aims compare sensorimotor function patients who have with those constipation. METHODS: We studied 50 consecutive female referred 2 or more also satisfied Rome II criteria for either (n = 25; mean age, 47 ± 3 y) 49 y). Assessments included Integrative...
Abstract Background Anorectal manometry (ARM) and balloon expulsion test (BET) are pivotal in investigation of anorectal disorders. There is controversy, however, about normal values optimum methodology for performing these tests. Our aims were to compare BET using three different balloons establish ARM health. Methods Forty‐four female healthy subjects (mean age 56 ± 12 years) underwent ARM, followed by which was performed a private toilet catheters (party balloon, Foley catheter...
Rationale: Visceral sensation and motility are important in functional gut disorders partly controlled by adrenergic innervation. Objectives: To characterize the α 2 ‐adrenergic control of motor sensory function descending colon rectum. Methods: In 32 healthy volunteers, we assessed compliance, fasting postprandial tone, sensations gas, urgency pain during phasic distentions. Each subject received one agent at clinically approved doses: clonidine (0.05, 0.1, 0.2 or 0.3 mg p.o.); antagonist...
Pelvic floor dyssynergia (PFD) within irritable bowel syndrome (IBS) is often overlooked and the relationship between symptoms physiology relatively unexplored. Our aims were to determine relationships clinical features anorectal function in non-diarrhea predominant IBS (non-D IBS) patients whether certain or physiological predict PFD IBS.Two groups of evaluated. Group I: 32 female non-D with >or=2 suggesting underwent comprehensive symptom assessment. II: recruited from community...
OBJECTIVES: Abdominal bloating and distension are common in patients with constipation. The precise mechanism of abdominal remains uncertain. We hypothesized that constipated plus exhibit a greater degree anorectal dysfunction, potentially affecting gas evacuation, than those without distension. Therefore, our aim was to evaluate function other clinical features constipation who METHODS: In all, 88 female either non-diarrhea irritable bowel syndrome (IBS) or functional were included the...
The rectoanal inhibitory reflex facilitates defecation by relaxation of the internal anal sphincter during rectal distention gas or stool. Defecation is sometimes preceded high-amplitude propagated contractions (HAPCs). Our objective was to seek evidence for motor coordination between human colonic and functions.As part a study alpha2 modulation functions in 32 healthy volunteers, we studied relationship high HAPCs pressure with manometry, barostat, Dent sleeve canal.Twenty-two were...
Sixteen patients with metastatic disease to the liver (12 colorectal and four unknown primary tumors) were treated in a pilot study of hepatic irradiation (2500-3000 rads 10-12 fractions) delivered concomitantly continuous short-term intraarterial infusion 5-fluorouracil (1 g/d) or FUDR (0.5 mg/kg/d) via percutaneously placed artery catheter. Abnormal function tests, including SGOT, LDH, alkaline phosphatase, decreased all by day 7-10 treatment, other metabolic factors, serum cholesterol,...
Abstract Background Long‐term outcome data for anorectal biofeedback ( BF ) fecal incontinence FI is scarce. Our aims were to describe the long‐term symptom profile, quality of life, and need surgery in patients following . Methods One hundred eight consecutive female with who completed an instrumented course identified follow‐up. In 61 89 contactable patients, measures assessed at short‐term (end ), mid‐term (9 months median), (7 years median) follow‐up after treatment. Key Results response...