A5057227631- Health Policy Implementation Science
- Obesity, Physical Activity, Diet
- School Health and Nursing Education
- Smoking Behavior and Cessation
- Community Health and Development
- Behavioral Health and Interventions
- Primary Care and Health Outcomes
- Health disparities and outcomes
- Physical Activity and Health
- Health Systems, Economic Evaluations, Quality of Life
- Child and Adolescent Health
- Substance Abuse Treatment and Outcomes
- Early Childhood Education and Development
- Eating Disorders and Behaviors
- Food Security and Health in Diverse Populations
- Evaluation and Performance Assessment
- Homelessness and Social Issues
- Adolescent Sexual and Reproductive Health
- Research in Social Sciences
- Health Promotion and Cardiovascular Prevention
- Child Nutrition and Feeding Issues
- Mental Health Research Topics
- Youth Development and Social Support
- Public Health Policies and Education
- Impact of Technology on Adolescents
MRC/CSO Social and Public Health Sciences Unit
2016-2025
University of Glasgow
2016-2025
University of Bristol
1995-2023
University of North Carolina at Chapel Hill
2023
University of Birmingham
2023
Cardiff University
2007-2021
Chief Scientist Office
2014-2021
Medical Research Council
2014-2021
Glasgow School of Art
2021
Search
2020
Process evaluation is an essential part of designing and testing complex interventions.New MRC guidance provides a framework for conducting reporting process studiesAttempts to tackle problems such as smoking obesity increasingly use interventions.These are commonly defined interventions that comprise multiple interacting components, although additional dimensions complexity include the difficulty their implementation number organisational levels they target. 1Randomised controlled trials...
Interferon alfa is widely used for metastatic renal-cell carcinoma but has limited efficacy and tolerability. Temsirolimus, a specific inhibitor of the mammalian target rapamycin kinase, may benefit patients with this disease.In multicenter, phase 3 trial, we randomly assigned 626 previously untreated, poor-prognosis to receive 25 mg intravenous temsirolimus weekly, million U interferon (with an increase 18 U) subcutaneously three times or combination therapy 15 weekly plus 6 weekly. The...
The UK Medical Research Council's widely used guidance for developing and evaluating complex interventions has been replaced by a new framework, commissioned jointly the Council National Institute Health Research, which takes account of recent developments in theory methods need to maximise efficiency, use, impact research.
Temsirolimus, a specific inhibitor of the mammalian target rapamycin kinase, has shown clinical activity in mantle cell lymphoma (MCL). We evaluated two dose regimens temsirolimus comparison with investigator's choice single-agent therapy relapsed or refractory disease.In this multicenter, open-label, phase III study, 162 patients MCL were randomly assigned (1:1:1) to receive one regimens: 175 mg weekly for 3 weeks followed by either 75 (175/75-mg) 25 (175/25-mg) weekly, from prospectively...
In this study, two doses of temsirolimus (CCI-779), a novel inhibitor the mammalian target rapamycin, were evaluated for efficacy, safety, and pharmacokinetics in patients with locally advanced or metastatic breast cancer who had been heavily pretreated.Patients (n = 109) randomly assigned to receive 75 250 mg weekly as 30-minute intravenous infusion. Patients tumor response, time progression, adverse events, temsirolimus.Temsirolimus produced an objective response rate 9.2% (10 partial...
The mammalian target of rapamycin (mTOR) pathway is up-regulated in many human cancers, and agents targeting the mTOR are various stages clinical development. goal study was to evaluate potential limitations renal cell carcinoma (RCC).Immunohistochemical analysis using antibodies against pAkt, PTEN, p27, pS6 performed on a tissue microarray constructed from paraffin-embedded specimens 375 patients treated by nephrectomy for RCC. expression associated with pathological parameters survival.The...
The Medical Research Council published the second edition of its framework in 2006 on developing and evaluating complex interventions. Since then, there have been considerable developments field intervention research. objective this project was to update light these developments. aims help research teams prioritise questions design, conduct with an appropriate choice methods, rather than provide detailed guidance use specific methods.
<b>Objective</b> To evaluate the effectiveness and costs of a multifaceted flexible educational programme aimed at reducing antibiotic dispensing practice level in primary care. <b>Design</b> Randomised controlled trial with general practices as unit randomisation analysis. Clinicians researchers were blinded to group allocation until after randomisation. <b>Setting</b> 68 about 480 000 patients Wales, United Kingdom. <b>Participants</b> 34 randomised receive be controls. 139 clinicians from...
Recent data showed improvement in progression-free survival (PFS) when adding everolimus to exemestane patients with advanced breast cancer experiencing recurrence/progression after nonsteroidal aromatase inhibitor (AI) therapy. Here, we report clinical outcomes of combining the mammalian target rapamycin (mTOR) temsirolimus letrozole AI-naive patients.This phase III randomized placebo-controlled study tested efficacy/safety first-line oral 2.5 mg daily/temsirolimus 30 daily (5 days every 2...
Existing guidance for developing public health interventions does not provide information researchers about how to work with intervention providers co-produce and prototype the content delivery of new prior evaluation. The ASSIST + Frank study aimed adapt an existing effective peer-led smoking prevention (ASSIST), integrating from UK drug education resource Talk ( www.talktofrank.com ) two school-based interventions. A three-stage framework was tested develop methods in collaboration key...
Headline Evaluating service innovations in health care and public requires flexibility, collaboration pragmatism; this collection identifies robust, innovative mixed methods to inform such evaluations.
LBA4 Background: Temsirolimus (TEMSR, CCI-779) is a specific inhibitor of mTOR, signaling protein that regulates cell growth and angiogenesis. In single-agent, phase 2 study, TEMSR administration to heavily pretreated patients (pts, n = 111) with adv RCC resulted in median overall survival (OS) 15.0 mos (Atkins et al, J Clin Oncol 2004). Retrospectively, 49 pts were categorized poor-risk group (Motzer 2002). The TEMSR-treated this had 1.7-fold longer OS than the first-line, IFN-treated,...
Abstract Purpose: Patients with advanced cancer received temsirolimus (Torisel, CCI-779), a novel inhibitor of mammalian target rapamycin, i.v. once daily for 5 days every 2 weeks to determine the maximum tolerated dose, toxicity profile, pharmacokinetics, and preliminary antitumor efficacy. Experimental Design: Doses were escalated in successive cohorts patients using conventional phase I clinical trial design. Samples whole blood plasma collected pharmacokinetics sirolimus, its principal...
Background In contrast to curriculum-based health education interventions in schools, the school environment approach promotes by modifying schools' physical/social environment. This systematic review reports on effects of and processes which these might occur. It includes theories, intervention outcome process evaluations, quantitative studies qualitative studies. Research questions question (RQ)1: What theories are used inform or explain school-level influences? testable hypotheses...
Evidence-based public health decision-making depends on high quality and transparent accounts of what interventions are effective, for whom, how at cost. Improving the reporting randomized non-randomized study designs through CONSORT TREND statements has had a marked impact designs. However, users systematic reviews have been concerned with paucity synthesized information context, development rationale, implementation processes sustainability factors.This paper examines existing frameworks...
Background The Wales National Exercise Referral Scheme (NERS) is a 16-week programme including motivational interviewing, goal setting and relapse prevention. Method A pragmatic randomised controlled trial with nested economic evaluation of 2160 inactive participants coronary heart disease risk (CHD, 1559, 72%), mild to moderate depression, anxiety or stress (79, 4%) both (522, 24%) receive (1) NERS (2) normal care brief written information. Outcome measures at 12 months included the 7-day...