A5086247686- Homelessness and Social Issues
- Antibiotic Use and Resistance
- Primary Care and Health Outcomes
- Substance Abuse Treatment and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Research in Social Sciences
- COVID-19 Clinical Research Studies
- Pharmaceutical industry and healthcare
- Emergency and Acute Care Studies
- Inflammatory Bowel Disease
- Simulation Techniques and Applications
- Microscopic Colitis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 diagnosis using AI
- Advanced Breast Cancer Therapies
- Public Health Policies and Education
- Delphi Technique in Research
- Pharmaceutical Economics and Policy
- Health Policy Implementation Science
- Healthcare Policy and Management
- Software Reliability and Analysis Research
- Patient Satisfaction in Healthcare
- Psychiatric care and mental health services
- Pharmaceutical Practices and Patient Outcomes
- Software Engineering Research
Qatar University
2017-2024
University of Chittagong
2024
Newham University Hospital
2018-2020
Gono University
2020
Hamad Medical Corporation
2020
Swansea University
1968-2017
University of South Wales
2006-2015
Animal Free Research UK
2010
Robert Gordon University
2008
Brunel University of London
2004
<b>Objective</b> To evaluate the effectiveness and costs of a multifaceted flexible educational programme aimed at reducing antibiotic dispensing practice level in primary care. <b>Design</b> Randomised controlled trial with general practices as unit randomisation analysis. Clinicians researchers were blinded to group allocation until after randomisation. <b>Setting</b> 68 about 480 000 patients Wales, United Kingdom. <b>Participants</b> 34 randomised receive be controls. 139 clinicians from...
BackgroundInfliximab and ciclosporin are of similar efficacy in treating acute severe ulcerative colitis, but there has been no comparative evaluation their relative clinical effectiveness cost-effectiveness.MethodsIn this mixed methods, open-label, pragmatic randomised trial, we recruited consenting patients aged 18 years or older at 52 district general teaching hospitals England, Scotland, Wales who had admitted, unscheduled, with colitis failed to respond intravenous hydrocortisone within...
<b>Objectives</b> To evaluate the effect of training primary care health professionals in behaviour change counselling on proportion patients self reporting four risk behaviours (smoking, alcohol use, exercise, and healthy eating). <b>Design</b> Cluster randomised trial with general practices as unit randomisation. <b>Setting</b> General Wales. <b>Participants</b> 53 practitioners practice nurses from 27 (one each at all but one practice) recruited 1827 who screened positive for least risky...
Background The efficacy of infliximab and ciclosporin in treating severe ulcerative colitis (UC) is proven, but there has been no comparative evaluation effectiveness. Objective To compare the clinical effectiveness cost-effectiveness steroid-resistant acute UC. Method Between May 2010 February 2013 we recruited 270 participants from 52 hospitals England, Scotland Wales to an open-label parallel-group, pragmatic randomised trial. Consented patients admitted with completed baseline...
Submissions to medical and scientific journals are vetted by peer review, but review itself has been poorly studied until recently. One concern that manuscript reviews in which the reviewer is unblinded (e.g. knows author identity) may be biased, with an increased likelihood evaluation will not strictly on merits.The purpose of this study was compare outcomes blinded manuscripts submitted a single dermatology journal via randomized multi-rater study.Forty Dermatologic Surgery were assessed...
<h3>Introduction</h3> Many patients with ulcerative colitis (UC) present acute exacerbations needing hospital admission. Treatment includes intravenous steroids but up to 40% of do not respond and require emergency colectomy. Mortality following colectomy has fallen, 10% still die within 3 months surgery. Infliximab ciclosporin, both immunosuppressive drugs, offer hope for treating steroid-resistant UC as there is evidence their short-term effectiveness. As little long-term evidence, this...
Background Obesity has significant health and NHS cost implications. Relatively small reductions in weight have clinically important benefits, but long-term loss maintenance (WLM) is challenging. Behaviour change interventions been identified as key for WLM. Motivation crucial to supporting behaviour change, motivational interviewing (MI) a successful approach changing behaviours. The study was designed an adequately powered, pragmatic randomised controlled trial (RCT); however, owing...
Klebsiella pneumoniae carbapenemase (KPC) belongs to the Group-A β-lactamases that incorporate serine at their active site and hydrolyze various penicillins, cephalosporins, carbapenems. Metallo-beta-lactamases (MBLs) are group-B enzymes contain one or two essential zinc ions in sites almost all clinically available β-lactam antibiotics. remains pathogen with most antimicrobial resistance KPC MBLs.This research investigated blaKPC, MBL genes, namely, blaIMP, blaVIM, blaNDM-1 phenotypic K....
Background Most patients presenting with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in primary care are prescribed antibiotics, but these may not be beneficial, and they can cause side effects increase the risk subsequent resistant infections. Point-of-care tests (POCTs) could safely reduce inappropriate antibiotic prescribing antimicrobial resistance. Objective To determine whether or use a C-reactive protein (CRP) POCT to guide decisions for AECOPD reduces...
Palbociclib and ribociclib are indicated in the first-line treatment of hormonal receptor-positive HER-2 negative (HR+/HER2- negative) advanced breast cancer. Although randomized-controlled trials (RCTs) proved their clinical efficacy, there no observational studies yet to validate findings real-world. Therefore, this study aimed evaluate compare effectiveness safety profiles palbociclib Qatar. A retrospective was conducted on HR+/HER-2-negative stage-IV cancer patients receiving or state...
Abstract The mass spectra of a series isatin, oxindole and 2‐oxo‐3‐indolyl derivatives have been investigated using high resolution deuterium labelling techniques. fragmentations involve the sequential loss number neutral molecules results show that concept charge localisation can be applied with success to explain fragmentation processes even in these polyheteroatom species.
To estimate and compare the optimal cut-off score of Alcohol Use Disorders Identification Test (AUDIT) AUDIT-C in identifying at-risk alcohol consumption, heavy episodic use, ICD-10 abuse dependence adolescents attending ED England. Opportunistic cross-sectional survey. 10 emergency departments across Adolescents (n = 5377) aged between their 10th 18th birthday who attended December 2012 May 2013. Scores on AUDIT AUDIT-C. At-risk consumption monthly past 3 months were derived using time-line...
AimThe aim of this study was to explore the awareness and views members ethnic minority community towards primary health care interpreting provision in two localities Hertfordshire.BackgroundEthnic groups often have undertake many aspects their day-to-day lives with limited English. The high quality language interpretation services is vital for enabling access public services, including healthcare. use accredited or professional interpreters has been minimal within undermines principle...
Alcohol is a major global threat to public health. Although the main burden of chronic alcohol-related disease in adults, its foundations often lie adolescence. consumption and related harm increase steeply from age 12 until 20 years. Several trials focusing upon young people have reported significant positive effects brief interventions on range alcohol outcomes. A recent review reviews also suggests that electronic (eBIs) using internet smartphone technologies may markedly reduce compared...
Information about the socioeconomic drivers of Silurus glanis anglers in UK were collected using questionnaires from a cross section mixed cyprinid fisheries to elucidate human dimensions angling and non-native management. Respondents predominantly male (95%), 30–40 years age with <10 yr experience for S. glanis; most had received college rather than university education. The majority (34%) employed low-moderate income status (<£30k per annum), which may restrict time expenditure spent on...
Most patients presenting with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in primary care are prescribed an antibiotic, which may not always be appropriate and cause harm. C-reactive protein (CRP) is acute-phase biomarker that can rapidly measured at the point predict benefit from antibiotic treatment AECOPD. It clear whether addition a CRP point-of-care test (POCT) to clinical assessment leads reduction consumption without having negative impact on COPD health...
Objectives: Metamodels have been used to approximate complex simulations and many applications with sensitivity analysis, optimization, etc. However, their use in health economics is very limited. Application of artificial neural network (ANN) a economic model has never investigated. The study intends introduce ANN as metamodeling method conduct analysis total hip replacement decision analytical compare its performance two other counterparts.Methods: First, nonlinear factor screening was...
Simulation metamodels have been used for optimization, prediction, sensitivity analysis and understanding of complex, real-world systems. Since most simulation models contain a large number input parameters, it is great interest to determine the important ones include in metamodel given particular modeling context, i.e. set questions which are be addressed by metamodel. This paper employs Morris' randomized one-at-a-time (OAT) design as factor screening method prior developing metamodels....
Abstract Background and Aims Premises licensed for the sale consumption of alcohol can contribute to levels assault‐related injury through poor operational practices that, if addressed, could reduce violence. We tested real‐world effectiveness an intervention designed change premises operation, whether any effect changed over time, dose. Design A parallel randomized controlled trial with unit allocation outcomes measured at level individual premises. Setting All (public houses, nightclubs or...