A5042728758- Grief, Bereavement, and Mental Health
- Palliative Care and End-of-Life Issues
- Migration, Health and Trauma
- Health Systems, Economic Evaluations, Quality of Life
- Homelessness and Social Issues
- Patient-Provider Communication in Healthcare
- Cardiac, Anesthesia and Surgical Outcomes
- Clinical practice guidelines implementation
- Childhood Cancer Survivors' Quality of Life
- Geriatric Care and Nursing Homes
- Delphi Technique in Research
- Hip and Femur Fractures
- Adolescent and Pediatric Healthcare
- Inflammatory Bowel Disease
- Patient Dignity and Privacy
- Dermatology and Skin Diseases
- Diabetes Management and Research
- Intergenerational Family Dynamics and Caregiving
- Microscopic Colitis
- Evaluation and Performance Assessment
- Patient Satisfaction in Healthcare
- Primary Care and Health Outcomes
- Nursing Roles and Practices
- Esophageal Cancer Research and Treatment
- Food Allergy and Anaphylaxis Research
Cardiff University
2015-2025
Marie Curie
2017-2024
Marie Curie Palliative Care Institute Liverpool
2021-2023
Department of Health and Social Care
2023
United Hospice
2023
University of Bristol
2022
Keele University
2022
University of Sheffield
2022
Marie Curie Hospice
2021
Queens University
2021
BackgroundInfliximab and ciclosporin are of similar efficacy in treating acute severe ulcerative colitis, but there has been no comparative evaluation their relative clinical effectiveness cost-effectiveness.MethodsIn this mixed methods, open-label, pragmatic randomised trial, we recruited consenting patients aged 18 years or older at 52 district general teaching hospitals England, Scotland, Wales who had admitted, unscheduled, with colitis failed to respond intravenous hydrocortisone within...
Purpose Venous thromboembolism (VTE) is common in cancer patients. Evidence has suggested that low molecular weight heparin (LMWH) might improve survival patients with by preventing both VTE and the progression of metastases. No trial a single type been powered to demonstrate clinically significant difference. The aim this was investigate question lung cancer. Patients Methods We conducted multicenter, open-label, randomized evaluate addition primary prophylactic dose LMWH for 24 weeks...
Background: Experiences of end-of-life care and early bereavement during the COVID-19 pandemic are poorly understood. Aim: To identify clinical demographic risk factors for sub-optimal pandemic-related challenges prior to death in bereavement, inform practice, policy support. Design: Online national survey adults bereaved UK (deaths between 16 March 2020 2 January 2021), recruited via media, social associations organisations. Setting/participants: 711 participants, mean age 49.5 (SD 12.9,...
The COVID-19 pandemic has been a devastating, mass bereavement event characterised by high levels of disruption to end-of-life, grieving and coping processes. Quantitative evidence is emerging on the effects grief outcomes, but rich qualitative lived experiences people bereaved during these times lacking.
Background The efficacy of infliximab and ciclosporin in treating severe ulcerative colitis (UC) is proven, but there has been no comparative evaluation effectiveness. Objective To compare the clinical effectiveness cost-effectiveness steroid-resistant acute UC. Method Between May 2010 February 2013 we recruited 270 participants from 52 hospitals England, Scotland Wales to an open-label parallel-group, pragmatic randomised trial. Consented patients admitted with completed baseline...
Background: The COVID-19 pandemic is a mass bereavement event which has profoundly disrupted grief experiences. Understanding support needs and access to among people bereaved at this time crucial ensuring appropriate infrastructure. Aim: To investigate experiences, use of formal informal during the pandemic. Design: Baseline results from longitudinal survey. Support experiences accessing are reported using descriptive statistics thematic analysis free-text data. Setting/participants: 711...
Background The COVID-19 pandemic has been a devastating and enduring mass-bereavement event, with uniquely difficult sets of circumstances experienced by people bereaved at this time. However, little is known about the long-term consequences these experiences, including prevalence Prolonged Grief Disorder (PGD) other conditions in pandemic-bereaved populations. Methods A longitudinal survey UK between 16 March 2020 2 January 2021, data collected baseline ( n = 711), c. 8 383), 13 295), 25...
To evaluate the effectiveness on glycaemic control of a training programme in consultation skills for paediatric diabetes teams.Pragmatic cluster randomised controlled trial.26 UK secondary and tertiary care services.79 healthcare practitioners (13 teams) trained intervention (359 young people with type 1 aged 4-15 years their main carers) 13 teams allocated to group (334 children carers).Talking Diabetes programme, which promotes shared agenda setting guiding communication style, through...
Abstract Background Bereavement support is a core part of palliative care. However, the evidence base limited by lack consistency in outcomes used to evaluate services and models support, which makes it difficult compare approaches. Core Outcome Sets (COS) represent minimum that should be measured research into specific conditions or services. The aim this study was use stakeholders’ perspective develop COS for evaluating bereavement adults adult care settings. Methods A list relevant...
During the COVID-19 pandemic, many children and young people have experienced death of close family members, whilst also facing unprecedented disruption to their lives. This study aimed investigate experiences support needs bereaved from perspective parents guardians.We analysed cross-sectional qualitative free-text data a survey adults in UK during pandemic. Participants were recruited via media, social national associations community/charitable organisations. Thematic analysis was...
Eczema may flare because of bacterial infection, but evidence supporting antibiotic treatment is low quality. We aimed to determine the effect oral and topical antibiotics in addition emollient corticosteroids children with clinically infected eczema.We employed a 3-arm, blinded, randomized controlled trial UK ambulatory care. Children clinical, non-severely eczema were receive placebos (control), (flucloxacillin) placebo, or (fusidic acid) for 1 week. compared Patient Oriented Measure...
Background Secondary skin infection is common during eczema exacerbations and many children are treated with antibiotics when this suspected, although there little high-quality evidence to justify practice. Objective To determine the clinical effectiveness of oral topical antibiotics, in addition standard treatment emollients corticosteroids, clinically infected eczema. Design Multicentre randomised, double-blind, placebo-controlled trial. Setting General practices dermatology clinics...
Abstract Introduction This qualitative study explored patients’ experiences and perceptions of the SCOPE2 trial. The trial studied radiotherapy dose escalation in patients with inoperable oesophageal cancer treated definitive chemo-radiation. embedded a phase II for poor early response using positron emission tomography (PET) scans. Methods longitudinal interview took place between 2017 2021. Patients eligible chemoradiotherapy were recruited from five clinical sites UK. Participants invited...
To estimate the feasibility, utility and resource implications of electronically captured routine data for health technology assessment by randomised controlled trials (RCTs), to recommend how routinely collected could be made more effective this purpose.Four assessments that involved patients under care at five district general hospitals in UK using four conditions from distinct classical specialties: inflammatory bowel disease, obstructive sleep apnoea, female urinary incontinence, total...
Voluntary and community sector bereavement services are central to support in the UK.To determine service providers' perspectives on access their before during COVID-19 pandemic.Mixed methods study using an explanatory sequential design: (1) Cross-sectional online survey of UK services; (2) Qualitative interviews with staff volunteers at selected services.147 participated survey; 24 were conducted across 14 services.67.3% reported there groups unmet needs not accessing pandemic; most...
Background The effectiveness of using point-of-care (POC) urine culture in primary care on appropriate antibiotic use is unknown. Aim To assess whether the Flexicult ™ SSI-Urinary Kit, which quantifies bacterial growth and determines susceptibility at point care, achieves that more often concordant with laboratory results, when compared standard care. Design setting Individually randomised trial females uncomplicated urinary tract infection (UTI) research networks (PCRNs) England,...
Objectives To explore paramedics’ experience of delivering fascia iliaca compartment block ( FICB) to patients with suspected hip fracture at the scene injury. Design Focus groups within a randomised controlled trial. Setting Paramedics based ambulance stations in catchment area one Emergency Department South Wales, recruited and trained feasibility study about an alternative routine prehospital pain management for fracture. Participants 11 paramedics. Intervention Paramedic-administered...
Objective To develop and evaluate a health-care communication training programme to help diabetes professionals (HCPs) counsel their patients more skilfully, particularly in relation behaviour change. Design The HCP was assessed using pragmatic, cluster randomised controlled trial. primary secondary analyses were intention-to-treat comparisons of outcomes multilevel modelling allow for (service) individual effects, involved two-level linear models. Setting Twenty-six UK paediatric services....