A5066228536- Scoliosis diagnosis and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Spinal Fractures and Fixation Techniques
- Diabetes Management and Research
- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Microscopic Colitis
- Diabetes and associated disorders
- Emergency and Acute Care Studies
- Lung Cancer Treatments and Mutations
- Pelvic and Acetabular Injuries
- Healthcare Policy and Management
- Patient Satisfaction in Healthcare
- Spine and Intervertebral Disc Pathology
- Patient-Provider Communication in Healthcare
- Trauma and Emergency Care Studies
- Esophageal Cancer Research and Treatment
- Primary Care and Health Outcomes
- Pancreatic and Hepatic Oncology Research
- Pancreatic function and diabetes
- Healthcare innovation and challenges
- Global Health Workforce Issues
- Geriatric Care and Nursing Homes
- Healthcare Systems and Technology
- Adolescent and Pediatric Healthcare
Swansea University
2014-2025
University of Calgary
2022
Food and Health Bureau
2012-2014
Beth Israel Deaconess Medical Center
2014
Chinese University of Hong Kong
2011
University of Hong Kong
2011
Hong Kong Polytechnic University
2009
University of Wales
2002-2007
Queen Nandi Regional Hospital
2007
Kwong Wah Hospital
2002-2003
To examine the psychometric properties of a revised scale, named 'observing patient involvement in decision making' (OPTION), by analysing its reapplication to sample routine primary care consultations. The OPTION instrument assesses what degree clinicians involve patients making.Cross-sectional assessment medical interaction two calibrated raters.Primary care.Twenty-one general practitioners provided 186 consultations for assessment.Observational score using instrument.Compared with first...
Abstract Background Health related quality of life (HRQL) has been recognised as an important paediatric outcome measurement. One the more promising measures to emerge in recent years is Pediatric Quality Of Life Inventory (PedsQL™), developed US. Advantages PedsQL™ include brevity, availability age appropriate versions and parallel forms for child parent. This study a UK-English version generic module assessed its performance group UK children their parents. Methods was translated...
Immunotherapy targeting the autoimmune process in type 1 diabetes (T1D) can delay loss of β-cells but needs to have minimal adverse effects be an adjunct insulin management T1D. Ustekinumab binds shared p40 subunit interleukin (IL)-12 and IL-23, development T helper cells 17 (T
ABSTRACT This paper is based on a study of the experiences people identified as ‘young carers’, commissioned by National Assembly for Wales part wider review carers’ needs and services. Following brief some previous research in this area, reports key findings research, using words children young much possible. It then goes to explore implications other identification support their families, understanding wishes so defined. The concludes with an alternative definition carer’ recommendations...
ObjectiveEndoscopic mucosal ablation is a promising technique that used to treat dysplastic Barrett's oesophagus. The purpose of this study was investigate the efficacy and cost-effectiveness two techniques, argon plasma coagulation (APC) photodynamic therapy (PDT), in oesophagus.Material methodsTwenty-six patients with oesophagus (21 M, median age 60 years, length 4 cm, 23 low-grade dysplasia (LGD), 3 high-grade (HGD)) were randomized APC: 13 patients, PDT: patients. APC performed at power...
Antigen-specific immunotherapy is an immunomodulatory strategy for autoimmune diseases, such as type 1 diabetes, in which patients are treated with autoantigens to promote immune tolerance, stop β-cell destruction and prevent permanent dependence on exogenous insulin. In this study, human proinsulin peptide C19-A3 (known its positive safety profile) was conjugated ultrasmall gold nanoparticles (GNPs), attractive drug delivery platform due the potential anti-inflammatory properties of gold....
<b>Introduction:</b> A high number of emergency (999) calls are made for older people who fall, with many patients not subsequently conveyed to hospital. Ambulance crews do generally have protocols or training leave at home, and systems referral rare. The quality safety current practice is explored in this study, which the first time, short-term outcomes left home by ambulance after a fall described. Results will inform development care population. <b>Methods:</b> Emergency data London were...
Between September 2004 and December 2005 we carried out a prospective study of all cases sepsis the hip in childhood at South African regional hospital with large local population, which also took referrals from nine rural hospitals. The clinical, radiological, ultrasound bacteriological features were assessed. All hips drained by arthrotomy diagnosis was confirmed microbiologically histologically. Hips tuberculosis excluded. children reviewed dedicated clinic mean follow-up 8.1 months (3 to...
Background Type 1 diabetes is an autoimmune disease affecting over 400,000 children and adults in the United Kingdom for which currently only available therapy insulin. Objective(s) To determine efficacy safety of monoclonal antibody ustekinumab targeting interleukin 12/interleukin 23 immune pathway that generates T helper 1/T 17 cells to slow down process preserve beta cell production type diabetes. Design Randomised, double-blind, placebo-controlled, parallel-group phase II trial. Setting...
Background and Study Aims: The value of methylene blue-directed biopsies (MBDB) in detecting specialized intestinal metaplasia dysplasia Barrett's esophagus remains unclear. aim this study was to compare the accuracy MBDB with random biopsy patients esophagus. Patients Methods: A prospective, randomized, cross-over trial undertaken segments 3 cm or more length without macroscopic evidence cancer. Dysplasia graded as: indefinite for dysplasia, low-grade high-grade carcinoma, reported a...
Abstract Title. Real nursing? The development of telenursing Aim. This paper is a report study to understand the impact from perspective nurses involved in its provision, and more traditional roles. Background. Nurse‐led telephone helplines have recently been introduced across United Kingdom, major step nursing practice. Method. A structured questionnaire was sent all working NHS Direct (National Health Service Direct) Wales service ( n = 111). Ninety‐two completed questionnaires were...
<b>Objective</b> To compare the clinical effectiveness of doctors and nurses in undertaking upper lower gastrointestinal endoscopy. <b>Design</b> Pragmatic trial with Zelen's randomisation before consent to minimise distortion existing practice. <b>Setting</b> 23 hospitals United Kingdom. In six hospitals, undertook both endoscopy, yielding a total 29 centres. <b>Participants</b> 67 30 nurses. Of 4964 potentially eligible patients, we randomised 4128 (83%) recruited 1888 (38%) from July 2002...
<h3>Introduction</h3> Many patients with ulcerative colitis (UC) present acute exacerbations needing hospital admission. Treatment includes intravenous steroids but up to 40% of do not respond and require emergency colectomy. Mortality following colectomy has fallen, 10% still die within 3 months surgery. Infliximab ciclosporin, both immunosuppressive drugs, offer hope for treating steroid-resistant UC as there is evidence their short-term effectiveness. As little long-term evidence, this...
Most of the disease-specific quality life (QoL) measures for inflammatory bowel disease (IBD) are lengthy and time consuming. None have been established routine use in clinical practice. We designed this study to develop a short QoL measure IBD.A 32-item questionnaire, Crohn's ulcerative colitis questionnaire (CUCQ)-32 was developed by reviewing literature previously validated questionnaires consultation with patients experts. Construct validity carried out using Short Form 12 EuroQol 5...
To estimate the feasibility, utility and resource implications of electronically captured routine data for health technology assessment by randomised controlled trials (RCTs), to recommend how routinely collected could be made more effective this purpose.Four assessments that involved patients under care at five district general hospitals in UK using four conditions from distinct classical specialties: inflammatory bowel disease, obstructive sleep apnoea, female urinary incontinence, total...
Aim. This paper reports a study of patients’ experiences this relatively new technology, and explores possible strategies for defining, delineating addressing concerns, problems needs. Background. The number patients in the community relying on percutaneous endoscopic gastrostomy their nutritional needs is increasing, but feeding not problem‐free. However, few studies report its impact from patient perspective. Methods. Twenty adults with long‐term gastrostomies were interviewed own homes,...
To examine the impact of structured self-monitoring blood glucose, with or without TeleCare support, on glycaemic control in people sub-optimally controlled Type 2 diabetes.We conducted a 12-month, multicentre, randomized trial established (>1 year) diabetes not insulin therapy, sub-optimal [HbA1c ≥58 to ≤119 mmol/mol (≥7.5% ≤13%)]. A total 446 participants were group (n =151) receiving usual care, using glucose alone =147) additional monthly 'TeleCare' support =148). The primary outcome was...
To compare the clinical outcome and cost-effectiveness of doctors nurses undertaking upper lower gastrointestinal endoscopy. The study was a pragmatic randomised controlled trial. Zelen's randomisation before consent used to minimise distortion existing practice in participating sites. An economic evaluation conducted alongside trial, assessing relative doctors. undertaken 23 hospitals England, Scotland Wales. In six undertook both endoscopy, yielding total 29 'centres'. coordinated managed...
This study aimed to estimate the prevalence of workplace violence involving radiographers in Hong Kong, evaluate underlying factors contributing incidents and their impact, suggest improvements management training.Frontline radiographers, from seven regional hospitals, who performed duties general radiography, were provided with a questionnaire. General radiography refers plain film X-ray services rooms (including out patient clinics), A&E portable on wards. Materials relating violence, for...