A5014553528- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Trace Elements in Health
- Diabetes and associated disorders
- Trauma Management and Diagnosis
- Trauma and Emergency Care Studies
- Emergency and Acute Care Studies
- Hemoglobin structure and function
- Diabetes Management and Research
- Colorectal Cancer Screening and Detection
- Neonatal Health and Biochemistry
- Pancreatic function and diabetes
- Satellite Image Processing and Photogrammetry
- Traumatic Brain Injury Research
- Atmospheric and Environmental Gas Dynamics
- Folate and B Vitamins Research
- Immune Cell Function and Interaction
- Healthcare professionals’ stress and burnout
- Psychosomatic Disorders and Their Treatments
- Traumatic Ocular and Foreign Body Injuries
- Public Health and Nutrition
- Health and Well-being Studies
- Marine and fisheries research
- COVID-19 and Mental Health
- Complementary and Alternative Medicine Studies
Swansea University
2021-2025
Truckee Meadows Community College
2025
Cardiff University
2007-2022
Swansea Bay University Health Board
2022
University of Wales
2002-2004
The Royal Free Hospital
2002
University College London
2002
Princess of Wales Hospital
2002
Welsh Government
2000
Nova Southeastern University
1996
People with genetic haemochromatosis (GH) accumulate iron from excessive dietary absorption. In populations of northern European origin, over 90% patients are homozygous for the C282Y mutation HFE gene. While about 1 in 200 people general population have this genotype proportion who develop clinical is not known. The influence on status was investigated 10 556 blood donors. allele frequencies and H63D mutations were 8·23% 15·3% respectively. Heterozygosity occurred 7·9 donors, 4·2 42...
Immunotherapy targeting the autoimmune process in type 1 diabetes (T1D) can delay loss of β-cells but needs to have minimal adverse effects be an adjunct insulin management T1D. Ustekinumab binds shared p40 subunit interleukin (IL)-12 and IL-23, development T helper cells 17 (T
ABSTRACT Motivation SNAPSHOT USA is an annual, multicontributor camera trap survey of mammals across the United States. The growing dataset intended for tracking spatial and temporal responses mammal populations to changes in land use, cover climate. These data will be useful exploring drivers relative abundance distribution, as well impacts species interactions on daily activity patterns. Main Types Variables Contained 2019–2023 contains 987,979 records image sequence 9694 deployment...
Background Type 1 diabetes is an autoimmune disease affecting over 400,000 children and adults in the United Kingdom for which currently only available therapy insulin. Objective(s) To determine efficacy safety of monoclonal antibody ustekinumab targeting interleukin 12/interleukin 23 immune pathway that generates T helper 1/T 17 cells to slow down process preserve beta cell production type diabetes. Design Randomised, double-blind, placebo-controlled, parallel-group phase II trial. Setting...
COVID-19 has caused severe disruption to clinical services in Bangladesh but the extent of this, and impact on healthcare professionals is unclear. We aimed assess perceived levels anxiety, depression burnout among doctors nurses during pandemic. undertook an online survey using RedCap, directed at across four institutions (The Sheikh Russel Gastro Liver Institute & Hospital (SRNGIH), Dhaka Medical College (DMCH), Mugda (MMCH) M Abdur Rahim (MARMC) Hospital). collected information...
In the UK, 90% of patients with hereditary haemochromatosis (HH) are homozygous for HFE C282Y, as one in 150 people general population. However, only a minority these will develop clinical haemochromatosis. Iron loss modifies iron accumulation but so may other genetic factors. Haptoglobin (Hp) exists three major types (Hp 1-1, Hp 2-1 or 2-2) and binds free plasma haemoglobin. men, 2-2 has been shown to be associated increased macrophage serum ferritin concentration. Furthermore, frequency...
The absorption of iron from Spatone Iron-Plus has been investigated in pregnant women with deficiency anaemia. A total 25 mg Fe was taken and determined the increase serum concentration during a period 3 h. Mean 28%, significantly higher than nonpregnant, nonanaemic (14%). These studies demonstrate that provides an alternative to standard ferrous sulphate tablet for prevention pregnancy. As only lower doses are required, unpleasant side-effects therapy largely avoided.
Acquired brain injury (ABI) and other chronic conditions are placing unprecedented pressure on healthcare systems. In the UK, 1.3 million people live with effects of injury, costing UK economy approximately £15 billion per year. As a result, there is an urgent need to adapt existing delivery meet increasing current future demands. A focus wellbeing may provide innovative opportunity reduce services while also supporting patients more meaningful lives. The overarching aims study as follows:...
Introduction Most individuals newly diagnosed with type 1 diabetes (T1D) have 10%–20% of beta-cell function remaining at the time diagnosis. Preservation residual diagnosis may improve glycaemic control and reduce longer-term complications. Immunotherapy has potential to preserve endogenous thereby metabolic even in poorly compliant individuals. We propose test ustekinumab (STELARA), a targeted well-tolerated therapy that halt T-cell cytokine-mediated destruction beta-cells pancreas Methods...
The majority of colorectal cancers (CRCs) are detected after symptomatic presentation to primary care. Given the shared symptoms CRC and benign disorders, it is challenging manage risk missed diagnosis. Colonoscopy resources cannot keep pace with increasing demand. There a pressing need for access simple triage tools in care help prioritise patients referral.To evaluate performance novel spectroscopy-based blood test care.Mixed-methods pilot study GP focus group discussions South...
Over 90% of patients with hemochromatosis in the United Kingdom are homozygous for C282Y mutation on HFE gene. The Centers Disease Control (CDC) States has recommended that adults should be screened mutations to identify susceptible individuals before onset disease. aim this study was evaluate polymerase chain reaction using sequence-specific primers (PCR-SSP) as a method large-scale population screening common gene mutations, H63D and C282Y. A total 10,583 consenting blood donors were...
Abstract Objectives To explore the perceptions of patients and healthcare professionals on Raman‐faecal immunochemical test (FIT) as an alternative for colorectal cancer exclusion in primary care. Design Semi‐structured interviews within a feasibility study. Setting Patients presenting to care with symptoms working secondary Participants A total 23 12 professionals. Methods Patient participants were asked complete novel combined Raman‐FIT before being seen This study sought their opinions...
Langlois et al (2000) have provided evidence to show that the haptoglobin (Hp) type 2-2 may be associated with iron retention in macrophages and higher serum ferritin concentrations than other Hp types. We agree such changes long-term consequences resulting from tissue damage due accumulation. were therefore surprised by our results (Carter al, 2003). Initially we found was more frequent C282Y homozygous patients haemochromatosis subjects detected genetic testing among blood donors. However,...
Abstract Introduction: At present, vaccines form the only mode of prophylaxis against COVID-19. The time needed to achieve mass global vaccination and emergence new variants warrants continued research into other COVID-19 prevention strategies. severity infection is thought be associated with initial viral load for occur, viruses including SARS-CoV-2 must first penetrate respiratory mucus attach host cell surface receptors. Carrageenan, a sulphated polysaccharide extracted from red edible...