A5017700966- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Influenza Virus Research Studies
- Respiratory viral infections research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Diet, Metabolism, and Disease
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Xenotransplantation and immune response
Cardiff University
2021-2025
University of Oxford
2000-2007
John Radcliffe Hospital
1997-2000
Immunotherapy targeting the autoimmune process in type 1 diabetes (T1D) can delay loss of β-cells but needs to have minimal adverse effects be an adjunct insulin management T1D. Ustekinumab binds shared p40 subunit interleukin (IL)-12 and IL-23, development T helper cells 17 (T
Background Type 1 diabetes is an autoimmune disease affecting over 400,000 children and adults in the United Kingdom for which currently only available therapy insulin. Objective(s) To determine efficacy safety of monoclonal antibody ustekinumab targeting interleukin 12/interleukin 23 immune pathway that generates T helper 1/T 17 cells to slow down process preserve beta cell production type diabetes. Design Randomised, double-blind, placebo-controlled, parallel-group phase II trial. Setting...
OF IMMUNOgenic vaccines against major encapsulated pathogens of childhood has dramatically decreased the rates invasive disease caused by Haemophilus influenzae type b, serogroup C Neisseria meningitidis, and Streptococcus pneumoniae in developed countries fortunate enough to be able afford vaccines.Since introduction a monovalent meningococcal glycoconjugate vaccine (MenC) into UK routine immunization schedule November 1999, group 87% ages targeted for vaccination, with estimated efficacy...
<h3>OB JECTIVES</h3> To assess the persistence of serum<i>Haemophilus influenzae</i> type b antibodies and prevalence <i>H carriage in a group preschool age children previously vaccinated infancy. <h3>DESIGN</h3> Names were randomly selected from immunisation records. Families visited on five occasions over period 12 months throat swabs taken all family members present, with blood obtained at first last visits. <h3>RESULTS</h3> One hundred fifty three median 3.6 years had geometric mean...
Background: Protein-polysaccharide conjugate vaccines against Neisseria meningitidis serogroup C were introduced into the U.K. routine immunization schedule in 1999. This study is first to describe both persistence of antibody and evidence for induction immune memory using meningococcal (MCC) vaccine preterm infants. Methods: Immunogenicity immunologic by as MCC was assessed premature infants; 62 60 term controls received at accelerated (2, 3 4 months age). A polysaccharide challenge...
Type 1 diabetes (T1D) screening programmes testing islet autoantibodies (IAbs) in childhood can reduce life-threatening diabetic ketoacidosis. General population is required to detect the majority of children with T1D, since >85% there no family history. Age 3-5 years has been proposed as an optimal age for a single screen approach.
Introduction Most individuals newly diagnosed with type 1 diabetes (T1D) have 10%–20% of beta-cell function remaining at the time diagnosis. Preservation residual diagnosis may improve glycaemic control and reduce longer-term complications. Immunotherapy has potential to preserve endogenous thereby metabolic even in poorly compliant individuals. We propose test ustekinumab (STELARA), a targeted well-tolerated therapy that halt T-cell cytokine-mediated destruction beta-cells pancreas Methods...
Background: Islet autoantibody screening for type 1 diabetes (T1D) reduces life-threatening diabetic ketoacidosis, hospitalization and identifies individuals eligible future preventative treatments. 3.5-4 years has been indicated as an optimal time to screen younger children T1D at a single-time point. We therefore assessed the feasibility acceptability of this age, align with pre-school vaccination visit, in first its kind, proof-of-concept study UK. Methods: Children attending routine...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
ABSTRACT Objective Type 1 diabetes (T1D) screening programmes testing islet autoantibodies (IAbs) in childhood can reduce life-threatening diabetic ketoacidosis. General population is required to detect the majority of children with T1D, since >85% there no family history. Age 3-5 has been proposed as an optimal age for a single screen approach. Design Capillary samples were collected from attending their pre-school vaccination and analysed IAbs insulin, glutamic acid decarboxylase,...