A5061360332- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Dietary Effects on Health
- Mycobacterium research and diagnosis
- Patient-Provider Communication in Healthcare
- Health Literacy and Information Accessibility
- Colorectal Cancer Screening and Detection
- Molecular Biology Techniques and Applications
- Muscle metabolism and nutrition
- Clinical Nutrition and Gastroenterology
- Urologic and reproductive health conditions
- Gastrointestinal disorders and treatments
- Inflammatory Bowel Disease
- Skin Protection and Aging
- Biomarkers in Disease Mechanisms
- Dermatologic Treatments and Research
- Antioxidants, Aging, Portulaca oleracea
- Pharmaceutical studies and practices
- Digestive system and related health
- Pregnancy and Medication Impact
- Cancer Genomics and Diagnostics
- History of Science and Medicine
- Spectroscopy Techniques in Biomedical and Chemical Research
Swansea University
2020-2023
Singleton Hospital
2018-2023
Swansea Bay University Health Board
2020-2023
Fera Science (United Kingdom)
2017
Morriston Hospital
2010
Women's & Children's Health Research Institute
2004
List of illustrations Acknowledgements Introduction Andrew Cunningham and Perry Williams 1. Laboratories, medicine public life in Germany, 1830-1849: ideological roots the institutional revolution Timothy Lenoir 2. Building institutes for physiology Prussia, 1836-1846: contexts, interests rhetoric Richard L. Kremer 3. The fall rise professional mystery: epistemology, authority emergence laboratory nineteenth-century America John Harley Warner 4. Anaesthetics, ethics aesthetics vivisection...
<h3>Background</h3> Little is known about optimal fluid therapy for patients with sepsis without shock who present to the ED. In this study, we aimed quantify effect of a challenge on non-invasively measured Cardiac Index (CI) in presenting shock. <h3>Methods</h3> prospective cohort CI, stroke volume (SV) and systemic vascular resistance (SVR) were 30 ED large teaching hospital Netherlands between May 2018 March 2019 using ClearSight system. After baseline measurements performed, passive leg...
Background The interaction of the gut microbiota with human host is implicated in pathogenesis inflammatory and immunological diseases including ulcerative colitis (UC). Faecal transplantation (FMT) as a method restoring microbial diversity increasing interest therapeutic approach management UC. current literature lacks consensus about dose FMT, route administration duration response. Methods analysis This single-blinded randomised trial will explore feasibility FMT 30 treatment-naïve...
The majority of colorectal cancers (CRCs) are detected after symptomatic presentation to primary care. Given the shared symptoms CRC and benign disorders, it is challenging manage risk missed diagnosis. Colonoscopy resources cannot keep pace with increasing demand. There a pressing need for access simple triage tools in care help prioritise patients referral.To evaluate performance novel spectroscopy-based blood test care.Mixed-methods pilot study GP focus group discussions South...
Suspected colorectal cancer (CRC) referrals based on non-specific symptoms currently lead to large numbers of patients being referred for invasive investigations and poor yield in detection. Secondary care diagnostics, particularly endoscopy, struggle meet the ever-increasing demand face lengthy waits from point referral. Here we propose a blood test utilising high-throughput Raman spectroscopy machine learning as an accurate triage tool. We present results first mixed methods clinical...
Abstract Background Dysbiosis of the gut microbiota may be responsible for pathogenesis ulcerative colitis (UC). Restoration diversity by means faecal transplantation (FMT) is increasing interest as a therapeutic option in management UC. The aims this phase II feasibility study are to estimate magnitude treatment response FMT treatment-naïve patients with newly diagnosed UC, evaluate donor and patient recruitment rates determine optimal conditions III (ISRCTN 58082603). Methods...
This cutting edge review article provides an in-depth perspective focusing on manipulation of the human microbiome using technique faecal microbiota transplantation for improvement patient outcomes in surgical disease. Some most recent publications this area are discussed, and commentary provided regarding their findings future perspective.
We compared the oral microbiome of wild wood mice (Apodemus sylvaticus) at four ages (18, 22, 26 and 30 weeks). 25 captured bred FERA Science were swabbed orally microbial population was characterized by aerobic anaerobic culture methods followed 16S rRNA sequencing. The total bacterial counts in found to be ~107 cfu/ml among all age groups, which 10-fold higher than our laboratory “specific pathogen free” (SPF) mice. predominant genera identified Pasteurella, Lactobacillus, Neisseria...
Introduction: Raised levels of the S100 protein complex cal-protectin and A12 may reflect inflammatory changes in gut, such as IBD. The aim this prospective study was to determine if calprotectin were elevated children at presentation with Methods: Children enrolled prospectively over 18 months. Patient groups included bowel disease (n=31:Crohn’s=24), control (coeliac disease: n=14) normal controls (n=13). Protein serum mucosal tissue measured by ELISA. Fluorescent immunohistochemical...
Abstract Background : To establish what online decision aids are currently available for patients contemplating pelvic exenteration (PE) locally advanced and recurrent rectal cancer (LARC LRRC). Methodology: A grey literature review was carried out using the Google Search TM engine undertaken a predefined search strategy (PROSPERO database CRD42019122933). Written health information assessed DISCERN criteria International Patient Decision Aids Standards (IPDAS) with readability content...