A5048691800- Colorectal Cancer Surgical Treatments
- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Diverticular Disease and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Abdominal Surgery and Complications
- Colorectal and Anal Carcinomas
- Hernia repair and management
- Reformation and Early Modern Christianity
- American Constitutional Law and Politics
- Gastrointestinal disorders and treatments
- Surgical Simulation and Training
- Gut microbiota and health
- Anorectal Disease Treatments and Outcomes
- Anatomy and Medical Technology
- Genetic factors in colorectal cancer
- Appendicitis Diagnosis and Management
- Minimally Invasive Surgical Techniques
- Gastrointestinal Tumor Research and Treatment
- Microscopic Colitis
- Pancreatic and Hepatic Oncology Research
- Intestinal and Peritoneal Adhesions
- Autoimmune and Inflammatory Disorders
University of Limerick
2016-2025
University Hospital Limerick
2016-2025
University College London Hospitals NHS Foundation Trust
2025
University College London
2002-2025
University of Leicester
2011-2023
Canadian Arthritis Patient Alliance
2020
UF Health Shands Hospital
2020
University of Florida Health Science Center
2020
University of Florida Health
2020
Mount Sinai Health System
2020
Ileal pouch anal anastomosis (IPAA) is the treatment of choice for chronic, medically refractory mucosal ulcerative colitis, indeterminate familial adenomatous polyposis (FAP), and a select group patients with Crohn's disease.: We report outcomes, complications, quality life (QOL) in cohort 3707 treated at our institution from January 1984 to March 2010.Data were collected prospectively maintained database chart review consecutive primary IPAA cases. Patient demographics, postoperative...
BACKGROUND: Debate persists regarding the role of Desulfovibrio subspecies in ulcerative colitis. Combined microscopic and molecular techniques enable this issue to be investigated by allowing precise enumeration specific bacterial species within colonic mucous gel. The aim study was combine laser capture microdissection quantitative polymerase chain reaction determine copy number crypt-associated gel health acute chronic METHODS: Colonic mucosal biopsies were harvested from healthy controls...
<h3>Objectives</h3> The relevance of spatial composition in the microbial changes associated with UC is unclear. We coupled luminal brush samples, mucosal biopsies and laser capture microdissection deep sequencing gut microbiota to develop an integrated assessment community controls UC. <h3>Design</h3> A total 98 samples were sequenced a mean depth 31 642 reads from nine individuals, four control volunteers undergoing routine colonoscopy five patients surgical colectomy for...
Abstract Akkermansia muciniphila utilises colonic mucin as its substrate. Abundance is reduced in ulcerative colitis (UC), the relative proportion of sulphated mucus gel layer (MGL). It unknown if these phenomena are related, however mucins could contribute to abundance, owing a lack The aim this study was quantify A. within MGL and relate findings with markers inflammation sulphomucin present. Colonic biopsies brushings were obtained from 20 patients active UC (AC), 14 quiescent (QUC)...
In Brief Background/Objective: Postoperative ileus (POI) after colorectal surgery is associated with prolonged hospital stay and increased costs. The aim of this study to investigate pre-, intra-, postoperative risk factors the development POI in patients undergoing laparoscopic partial colectomy. Methods: Patients operated between 2004 2008 were retrospectively identified from a prospectively maintained database, clinical, metabolic, pharmacologic data obtained. was defined as absence bowel...
In Brief Objective: To evaluate whether resident participation in operations influences postoperative outcomes. Background: Identification of potential differences outcome associated with may facilitate planning from educational and health resource perspectives. Methods: From the National Surgical Quality Improvement Program database (2005–2007), outcomes were compared for patients without (RES vs no-RES). Groups matched a 2:1 ratio, based on age, sex, specialty, surgical procedure,...
Abstract Background Emerging evidence suggests that a laparoscopic approach to colorectal procedures generates fewer adhesions. Even though ileal pouch–anal anastomosis (IPAA) is lengthy procedure, the prospect of adhesions may justify this approach. The aim study was assess abdominal and adnexal adhesion formation following versus open IPAA in patients with ulcerative colitis. Methods A diagnostic laparoscopy performed at time ileostomy closure. All quadrants pelvis were video recorded...
A randomized controlled trial was undertaken to investigate the effect of prophylactic negative pressure dressings on postoperative surgical site infection (SSI) rates in closed laparotomy wounds.Laparotomy wounds are associated with high SSI. The dressing incisional SSI rate is unknown.A randomized, controlled, open-label conducted (clinicaltrials.gov registration number NCT02780453). Fifty patients undergoing open abdominal surgery were included, 25 group and standard group. primary...
The aim of this study was to characterize formally the mesocolic anatomy during and following total excision. Total excision may improve survival in patients with colon cancer. Although requires a detailed knowledge normal variant anatomy, latter is poorly characterized. No studies have prospectively characterized entire mesocolon.Total performed 109 undergoing abdominal colectomy. mesocolon maintained intact thereby permitting precise anatomical characterization from ileocaecal mesorectal...
Colonic mobilization requires separation of mesocolon from underlying fascia. Despite the surgical importance planes formed by these structures, no study has formally characterized their microscopic features. The aim this was to determine histological and electron appearance mesocolon, fascia, retroperitoneum, prior after colonic mobilization.In 24 cadavers, samples were taken right, transverse, descending, sigmoid mesocolon. In 12 specimens stained with hematoxylin eosin (3 sections) or...
Emerging evidence points to a link between creeping fat and the pathogenesis of Crohn's disease [CD]. Non-invasive assessment severity on cross-sectional imaging modality has seldom been investigated. This study aimed develop characterize novel mesenteric index [MCFI] based computed tomography [CT] in CD patients.MCFI was developed vascular findings CT retrospective cohort [n = 91] validated prospective 30]. The graded extent which extended around intestinal circumference using vessels as...
PURPOSE: Ileal pouch-anal anastomosis remains the “gold standard” in surgical treatment of ulcerative colitis and familial adenomatous polyposis. Pouchitis occurs mainly patients with a background colitis, although reasons for this are unknown. The aim study was to characterize differences pouch bacterial populations between pouches. METHODS: After ethical approval obtained, fresh stool samples were collected from pouches (n = 10), polyposis 7) pouches, ileostomies 8). Quantitative...