Abstract Akkermansia muciniphila utilises colonic mucin as its substrate. Abundance is reduced in ulcerative colitis (UC), the relative proportion of sulphated mucus gel layer (MGL). It unknown if these phenomena are related, however mucins could contribute to abundance, owing a lack The aim this study was quantify A. within MGL and relate findings with markers inflammation sulphomucin present. Colonic biopsies brushings were obtained from 20 patients active UC (AC), 14 quiescent (QUC)...

Background Akkermansia muciniphila and Desulfovibrio spp. are commensal microbes colonising the mucus gel layer of colon. Both species have capacity to utilise colonic mucin as a substrate. A. degrades mucin, while metabolise sulfate moiety sulfated mucins. Altered abundances these microorganisms been reported in ulcerative colitis (UC). However their bind human whether this binding is affected by changes associated with UC, remain be defined. Methods Mucin was isolated from resected colon...

Helicobacter pylori binds to the gastric mucin, MUC5AC, and trefoil factor, TFF1, which has been shown interact with mucin. We examined interactions of TFF1 H. purified gastrointestinal mucins from different animal species humans printed on a microarray platform investigate whether may play role in locating mucus. bound almost exclusively human did not colonic mucins. There was strong correlation between binding mucins, both that Griffonia simplicifolia lectin-II, is specific for terminal...

Postgraduate specialty training in Ireland is associated with considerable cost. Some of these are mandatory costs such as medical council fees, while others necessary to ensure career progression, attendance at courses and conferences. In particular, surgical specialities believed be high costs. It unknown how compare those borne by counterparts other specialities.The aims this study were 1. Quantify the amount that trainees spend on postgraduate 2. Determine whether a difference exists...

Gas gangrene is a life-threatening, necrotising soft tissue infection. Colorectal malignancy-associated <i>Clostridiumsepticum</i> rare cause of gas gangrene. This case outlines an initial presentation colonic malignancy as from <i>C.septicum</i> A 69-year-old man presented with abdominal pain, vomiting and constipation. Abdominal X-ray revealed dilated small bowel loops. Lactate was elevated. diagnosis obstruction made. Subsequent CT caecal thickening subcutaneous emphysema overlying the...

Abstract Butyrate is the primary energy source for colonocytes and essential mucosal integrity repair. deficiency as a result of colonic dysbiosis putative factor in ulcerative colitis (UC). Commensal microbes are butyrogenic, while others may inhibit butyrate, through hydrogenotropic activity. The aim this study was to quantify butyrogenic species determine their relationship with inflammation within mucus gel layer (MGL). Mucosal brushings were obtained from 20 healthy controls (HC),...

Background Surgical site infection in colon surgery is associated with significant cost and increased length of hospital stay. Recently, there has been interest the use pulsed lavage to reduce risk surgical contaminated wounds. Although increasingly used gaining popularity, its effectiveness elective colorectal poorly documented. This study aimed investigate incidence within 30 days patients who underwent wound irrigation pulse versus standard closure. Methodology A retrospective was...

Background: Antimicrobials are a major component in the management of surgical conditions and efficacious agents precious resource Antibiotic prescribing acute setting is frequently not adherent to best practice guidelines. The aims this study were determine: rate inappropriate antimicrobial admissions, if correlation existed between grade doctor prescribing, whether regimen was changed after review by senior surgeon.

Background: NICE guidelines recommend prophylactic low molecular heparin (LMWH) administration in all patients undergoing elective surgery. Studies show that LMWH should be administered at least peri-operatively to have optimal benefit (O'donnell and Weitz, 2003, Collins et al., 1988). In breast surgery, conflicting evidence regarding optimum timing of venous thromboembolism (VTE) prophylaxis exists, with some studies reporting an association between pre-operative wound haematoma formation....

Background: Changes in the colonic microbiome occur ulcerative colitis (UC). Several species have been implicated overall dysbiosis and may contribute to inflammation through trophic interactions with other or production of metabolites. Species that include those mucolytic, sulfidogenic butyrogenic potential. The aim this project was determine abundance mucolytic Akkermensia muciniphila, Desulfovibrio Rosburia hominis colitic colon. Methods: Paired mucosal brushings biopsies were obtained...

Background: Since the adoption of breast conserving therapy (BCT) in suitable patients with cancer, concerns over local recurrence rates have remained. Surveillance following BCT will inherently involve a rate ipsilateral needle biopsies. The aim this study is to interrogate and yield subsequent biopsies post BCT. Methods: A retrospective analysis was performed all who underwent an core biopsy between 2013 2017 prior Results: In total 308 undergoing surveillance for past history cancer 2017....

Background: The prognostic significance of axillary lymph node metastases in patients with breast cancer has long been established. Despite advances the molecular profiling cancers, nodal status remains an important determinant treatment. aim this study was to identify diagnostic yield from staging CT thorax, abdomen and pelvis (CT-TAP) prompted by finding on sentinel biopsy (SLNB). Methods: A retrospective review over a 5-year period 2013 2017 performed positive SLNB who proceeded undergo...

Background: In 2016 the American Society of Breast Surgeons generated thromboprophylaxis guidelines for breast surgery patients. There continues to be a paucity pertaining optimum timing venous thromboembolism (VTE) prophylaxis administration. Some studies have found enoxaparin not increase haematoma rates (Pannucci et al., 2012) but others show contradictory increased risk (Lapid 2012). Thus, further research is warranted determine if pre- or post-operative administration VTE effects rates.

Abstract Butyrate is the primary energy source for colonocytes and essential mucosal integrity repair. deficiency as a result of colonic dysbiosis putative factor in ulcerative colitis (UC). Commensal microbes are butyrogenic, while others have an inhibitory effect, through hydrogenotropic activity. The aim this study was to quantify butyrogenic species determine their relationship with inflammation within mucus gel layer (MGL).Mucosal brushings were obtained from 20 patients active (AC),...

Background: Total neoadjuvant therapy (TNT) is an emerging standard of care for locally advanced rectal cancer (LARC). Herein, we report a case complete pathological response following TNT in LARC with local bladder invasion. Methods: We the 35-year-old male who presented painless PR bleeding. He was otherwise fit and well no family history colorectal cancer. Sigmoidoscopy identified upper rectum. MR staging T4BN2Mx Results: The patient underwent defunctioning ileostomy completed FOLFIRINOX...

Background: Colitis is a clinical diagnosis made in conjunction with laboratory results, endoscopic and histological findings. There are patients who present acute abdominal pain CT arranged to investigate possible surgical pathology. occasionally identified which may warrant further investigation classify aetiology influence management. Methods: Review of all adult have computerized tomography abdomen pelvis (CTAP) reported colitis, features suggestive colitis recommended correlation from...

Background: Coronavirus disease 2019 (COVID-19) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a highly transmittable virus that has recently emerged in Wuhan, China before rapidly spreading worldwide. Due to the lack of prior immunity, COVID-19 pandemic been associated with high morbidity and mortality The main target were lungs occasionally manifesting as failure. Multiple organ dysfunction was also reported reverse transcription polymerase chain reaction (RT-PCR)...

Abstract Background Since the ACOSOG Z0011 trial, rates of axillary node clearance (ANC) for micrometastatic disease have declined among women undergoing breast conservation surgery (BCS). However, mastectomy, it remains unclear whether omission ANC is a safe and feasible option. Aims Identify current practice relating to management axilla in with early stage, clinically negative cancer, found on SNB, who undergo mastectomy Methods From 2013 2017 patients clinical T1-T2Nmi cancer upfront...