A5037815358- Bladder and Urothelial Cancer Treatments
- S100 Proteins and Annexins
- Epigenetics and DNA Methylation
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Ferroptosis and cancer prognosis
- TGF-β signaling in diseases
- Protease and Inhibitor Mechanisms
- Neonatal Respiratory Health Research
- Urinary and Genital Oncology Studies
- Genetic factors in colorectal cancer
- Fibroblast Growth Factor Research
- Biomarkers in Disease Mechanisms
- Kruppel-like factors research
- Clusterin in disease pathology
- Pain Mechanisms and Treatments
- Clinical Nutrition and Gastroenterology
- Pancreatic and Hepatic Oncology Research
- Polyomavirus and related diseases
- Childhood Cancer Survivors' Quality of Life
- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Cancer survivorship and care
- Natural Antidiabetic Agents Studies
- Preterm Birth and Chorioamnionitis
King Saud bin Abdulaziz University for Health Sciences
2019-2024
King Abdullah International Medical Research Center
2017-2024
National Guard Health Affairs
2018-2023
King Abdulaziz Medical City
2018
King Abdulaziz University
2013-2017
University of South Bohemia in České Budějovice
2016
University of Liverpool
2007-2015
King Fahad Hospital Jeddah
2014
Bentham Science Publishers (China)
2014
Bentham Science Publishers (United Arab Emirates)
2014
Abstract Background Nrf2 is a key transcriptional regulator of battery genes that facilitate phase II/III drug metabolism and defence against oxidative stress. largely regulated by Keap1, which directs for proteasomal degradation. The Nrf2/Keap1 system dysregulated in lung, head neck, breast cancers this affects cellular proliferation response to therapy. Here, we have investigated the integrity pancreatic cancer. Results target AKR1c1 GCLC were detected panel five cancer cell lines....
Abstract Background Chemotherapy‐induced peripheral neuropathic pain ( CIPNP ) is a serious dose‐limiting neurotoxic effect of cancer drug treatment. The underlying mechanism(s) this debilitating condition, which lacks effective treatment, incompletely understood. However, neural–immune interactions, involving increased expression and release cytokines, are believed to be involved. Here, we examined, in the paclitaxel rat model , whether plasma levels 24 cytokines/chemokines change after...
High levels of S100A6 have been associated with poor outcome in pancreatic cancer patients. The functional role is, however, poorly understood. Immunoprecipitation followed by two-dimensional gel electrophoresis and mass spectrometry were undertaken to identify interacting proteins cells. Immunohistochemistry coimmunofluorescence performed examine expression or colocalisation proteins. siRNA was used deplete specific effects on motility measured using Boyden Chamber wound healing assays. Our...
Amine and carboxylic acid-bifunctionalized iron oxide nanoparticles with robust silane linkages to the nanoparticle surface were prepared a versatile direct grafting protocol. The contrast in chemistry of these two groups was highlighted by attaching fluorophore, Rhodamine B isothiocyanate (RITC) onto amine group an antibody (EPCAM – epithelial cell adhesion molecule) acid groups. core RITC tags provide MRI-fluorescent bi-modal imaging capability. EPCAM is specific protein ubiquitously...
<h3>Objective</h3> There are currently no biomarkers in routine clinical use for determining prognosis rectal cancer. In a preliminary proteomic study, variation the levels of heat shock protein 27 (HSP27) colorectal cancer samples was observed. The expression HSP27 cohort 404 patients with predominantly poor characterised and an investigation undertaken whether differences were related to outcome. diagnostic biopsies compared matched surgical determine changes occurred time between biopsy...
The cellular defence protein Nrf2 is a mediator of oncogenesis in pancreatic ductal adenocarcinoma (PDAC) and other cancers. However, the control expression activity cancer not fully understood. We previously reported absence Keap1, pivotal regulator Nrf2, ∼70% PDAC cases. Here we describe novel mechanism whereby epigenetic UHRF1 suppresses Keap1 levels. was observed 20% (5 25) benign ducts compared to 86% (114 132) tumours, an inverse relationship between levels tumours (n = 124) apparent...
Her2/neu is an oncogene that plays important role in the pathogenesis of many cancer types. In bladder carcinoma (BC), clinical significance status remains under-investigated and poorly linked to patients' clinic-pathological features survival status. Thus, current study was conducted assess a cohort Saudi Arabia, explore its prognostic value BC. A total 160 consent patients transitional cell (TCC) were arranged on tissue microarray (TMA) stained by immunohistochemistry (IHC) bright-field...
The secretion of soluble factors enables communication between tumour cells and the surrounding microenvironment plays an important role in oncogenesis. Pancreatic ductal adenocarcinoma (PDAC) is characterised by a highly reactive microenvironment, harbouring variety cell types, including S100A8/S100A9-expressing monocytes. S100A8/S100A9 proteins regulate behaviour cancer inducing pre-metastatic cascades associated with spread. aim this study was to examine how S100A8/A9 mediate...
The diet of the horse, pasture forage (grass), is fermented by equine colonic microbiota to short-chain fatty acids, notably acetate, propionate and butyrate. Short-chain acids provide a major source energy for horse contribute many vital physiological processes. We aimed determine both mechanism butyrate uptake across luminal membrane colon nature protein involved. To this end, we isolated vesicles. abundance activity cysteine-sensitive alkaline phosphatase villin, intestinal markers, were...
Abstract The identification of clinically-relevant early diagnostic and prognostic protein biomarkers is essential to maximize therapeutic efficacy prevent cancer progression. aim the current study determine whether aberrant plasma profile can be applied as a surrogate tool for diagnosis bladder carcinoma. Plasma samples from patients with low grade non-muscle invasive healthy controls were analyzed using combined 2D-DIGE mass-spectrometry identify differentially expressed proteins....
Abstract The cross‐talk between tumour cells and the surrounding supporting host (stroma) is a key regulator of cancer growth progression. By undertaking 2‐DE analysis laser capture microdissected malignant stromal components pancreatic tumours benign ductal elements, we have identified high levels S100A8 S100A9 in tumour‐associated stroma but not or epithelia. Immunohistochemical ( n = 71 patients) revealed strong expression both proteins myeloid cells, subsequently as CD14 + /CD68 ‐...
S100A8 and its dimerization partner S100A9 are emerging as important chemokines in cancer. We previously reported that Smad4-negative pancreatic tumors contain fewer stromal S100A8-positive monocytes than their Smad4-positive counterparts. Here, we studied S100A8/A9-expressing cells colorectal relating presence to clinicopathological parameters Smad4 status. Two-dimensional gel electrophoresis ( n = 12) revealed variation the levels of protein cancer tumors, whereas immunohistochemical...
Metabolic diseases like diabetes and obesity are major risk factors for breast cancer. Aberrant expression of metabolic effectors such as fibroblast growth factor 19 (FGF19) could be therefore associated with the disease. The FGF19 was examined in 193 archival tumor samples by immunohistochemistry evaluated semi-quantitatively determining staining index correlating it clinicopathological parameters using Fisher's exact test. correlation between 5-year disease-specific survival rate...
Invasive ductal carcinoma of the breast is most common cancer affecting women worldwide. The marked heterogeneity matched only with in its associated or causative factors. Breast Saudi Arabia apparently an early onset many affected females diagnosed before they reach age 50 years. One possible rationale underlying this observation that consanguinity, which widely spread community, causing accumulation yet undetermined susceptibility mutations. Another factor could be epigenetic aberrations...
Pain is a common and dose-limiting side effect of many potentially curative cancer chemotherapeutic agents. This chemotherapy-induced pain (CIP) affects the quality life patients survivors hampers optimal clinical management chemotherapy in patients. The underlying mechanisms remain largely unknown, but changes levels cytokines/chemokines may contribute to pathophysiology CIP. retrospective study was aimed at examining whether plasma various cytokines change prostate after treatment such (if...
The glutathione S-transferases (GSTs) are a superfamily of phase II detoxifying enzymes that inactivates wide variety potential carcinogens through conjugation. Polymorphic changes in the GST genes have been reported to be associated with increased susceptibility cancer development and anticancer drug resistance. In this study, we investigated association between genetic variants GSTM1 GSTP1 patients' clinicopathological parameters. prognostic values such associations were evaluated among...
The enzyme glutathione S-transferase Mu 1 (GSTM1) is encoded by the GSTM1 gene.Polymorphisms in affect detoxifying function of variants.This forms basis debate about impact null/present genotype on colorectal carcinoma risk.We tested potential influence polymorphisms development cancer.DNA extracted from 83 samples ©FUNPEC-RP www.funpecrp.com.brGenetics and Molecular Research 15 (1): gmr.15017551 taken patients that were previously diagnosed as having 35 control subjects who did not have...
Secreted phosphoprotein-1 (SPP1) expression is differentially altered in many malignancies and could serve as a potential prognostic biomarker. Recent findings indicated that SPP1 possesses broader role bladder cancer (BC) pathogenesis than previously envisioned; however, the underlying mechanisms governing its expression, cellular localization, value immune-related remain poorly understood. The prognosis of were assessed using immunohistochemistry (IHC) staining on tissue microarray. was...
Bladder cancer (BC) is a deadly disease characterized by high recurrence rates and frequent progression to an aggressive phenotype. Dysregulation of various signaling pathways have been implicated in BC tumorigenesis, however, the clinical relevance sonic hedgehog pathway (Shh) remains under investigated. The aim current study was analyze prognostic value Shh expression patients with bladder carcinoma. Immunohistochemical performed using tissue microarray 128 specimens from patients....
Bladder cancer is a life-threatening disease and major cause of cancer-associated complications. The main challenges confronted during the clinical management bladder are associated with recurrence progression to muscle-invasive phenotype. Improved early detection paramount importance prevent improve survival. Hence, novel clinically applicable biomarkers for warranted. In current study, comparative proteomic approach was undertaken using plasma samples identify protein phenotype carcinoma....
Abstract Human Epidermal Growth Factor Receptor 2 (HER2) overexpression is considered one of the interesting prognostic biomarkers in bladder cancer. However, mechanism cancer development relation to HER2 status remains be elucidated. In this study, we investigated HER2‐Ataxia telangiectasia mutated (ATM) kinase interaction and their impact on patient survival aggressiveness. Using Cancer Genome Atlas (TCGA) cohorts, demonstrated that ATM expression (protein/mRNA) increased deficient...
Background: TIMP3 is a multifunctional proteolytic enzyme belonging to TIMPs family and acts as potent inhibitor of matrix metalloproteinases (MMPs). possesses tumor suppresive function by directly promoting cell apoptosis, preventing angiogenesis extracellular remodelling. The lower expression was associated with poor prognosis overall survival in various cancer types. aim this study evaluate the association protein ovarian (OC) clinicopathological features outcomes.Patients Methods: One...