A5026549825- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Bladder and Urothelial Cancer Treatments
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Biomedical Ethics and Regulation
- Cancer, Lipids, and Metabolism
- CRISPR and Genetic Engineering
- Noise Effects and Management
- Radiomics and Machine Learning in Medical Imaging
- Tumors and Oncological Cases
- Fibroblast Growth Factor Research
- COVID-19 Clinical Research Studies
- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Cardiovascular Disease and Adiposity
- RNA Interference and Gene Delivery
- AI in cancer detection
- CAR-T cell therapy research
- Hearing Loss and Rehabilitation
- Graphene and Nanomaterials Applications
King Saud bin Abdulaziz University for Health Sciences
2017-2024
King Abdullah International Medical Research Center
2017-2024
National Guard Health Affairs
2017-2023
King Abdulaziz Medical City
2018-2020
International Medical Research (Germany)
2018
Royal Women's Hospital
2016
The University of Melbourne
2016
OPINION article Front. Pharmacol., 30 March 2020 | https://doi.org/10.3389/fphar.2020.00384
Long non-coding RNAs (lncRNAs) have emerged as critical players in brain development and disease. These transcripts, which once considered “transcriptional junk,” are now known for their regulatory roles gene expression. In development, lncRNAs participate many processes, including neurogenesis, neuronal differentiation, synaptogenesis. They employ effect through a wide variety of transcriptional post-transcriptional mechanisms interactions with chromatin modifiers, transcription factors,...
Mesenchymal stem cells (MSCs) can influence the tumour microenvironment (TEM) and play a major role in tumourigenesis. Triple-negative [Ostrogen receptor (ER-), Progesterone (PgR-), HER2/neu (HER2-)] breast cancer (TNBC) is an aggressive class of BC characterized by poor prognosis lacks benefit routinely available targeted therapies. This study aims to investigate effect human placental chorionic villi derived MSCs (CVMSCs) on behavior TNBC vitro. was done assaying different hallmarks...
Abstract Human Epidermal Growth Factor Receptor 2 (HER2) overexpression is considered one of the interesting prognostic biomarkers in bladder cancer. However, mechanism cancer development relation to HER2 status remains be elucidated. In this study, we investigated HER2‐Ataxia telangiectasia mutated (ATM) kinase interaction and their impact on patient survival aggressiveness. Using Cancer Genome Atlas (TCGA) cohorts, demonstrated that ATM expression (protein/mRNA) increased deficient...
An in vivo animal model that mimics human cancer could have various applications deliver significant clinical information. The currently used techniques for the development of models considerable limitations. Therefore, this study, we aim to implement cell sheet technology develop an model. Hepatocellular carcinoma (HCC) is successfully developed nude rats using sheets created from HCC line cells. are generated through intracellular adhesion and formation a stratified structure, controlled...
Abstract The coronavirus disease (COVID-19) infection is causing significant morbidity and mortality rates worldwide. A comprehensive investigation of the characteristics, especially among vulnerable groups, could help better manage reduce pathogen's effect. This retrospective study examined impact COVID-19 on three groups patients with chronic diseases. We investigated clinical characteristics outcomes 535 cardiovascular diseases (CVD), kidney (CKD), Cancer that were admitted to Intensive...
Abstract Human epidermal growth factor receptor 2 (HER2/ ERBB2 ) is known to be implicated in many malignancies and the potential of it as a prognostic biomarker was reported years ago. Molecular subtypes HER2/ negative positive with distinct clinical outcomes have been identified recent years; however, still under investigation for bladder cancer. This study evaluates biological significance RAD21 , RAD50 BARD1 (homologous recombination biomarkers) mRNA levels low high expression explore...
Application software is utilized to aid in the diagnosis of breast cancer. Yet, recent advances artificial intelligence (AI) are addressing challenges related detection, classification, and monitoring different types tumors. AI can apply deep learning algorithms perform automated analysis on mammographic or histologic examinations. Large volume data generated by digitalized mammogram whole-slide images be interoperated through advanced machine learning. This enables fast evaluation every...
Objective This study examines the impact of COVID-19 pandemic on cochlear implantation (CI) recipients in Saudi Arabia. The was measured using results an online survey that investigated challenges related to access re/habilitation and programming services, increased dependence virtual interaction, emotional impact.Methods cross-sectional reached 353 pediatric adult CI between April 21st May 3rd 2020, during first weeks implementing lockdown strategy transitioning settings.Results It revealed...
Many mesenchymal stem cell (MSC)-based clinical trials are targeted toward cardiovascular diseases, specifically cardiac ischemia. Investigatory work has revealed that MSC-produced “exosomes” in fact the element initiates tissue restoration. This, addition to advantages of using exosomes over transplanting whole cells, makes “MSC-exosome-based therapy” a very appealing concept. This review will discuss and their possible applications, with particular emphasis on MSC-derived use managing...