A5077011338- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Breast Cancer Treatment Studies
- Colorectal Cancer Screening and Detection
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Protease and Inhibitor Mechanisms
- Forensic and Genetic Research
- Molecular Biology Techniques and Applications
- Cancer, Lipids, and Metabolism
- HER2/EGFR in Cancer Research
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Kruppel-like factors research
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Bladder and Urothelial Cancer Treatments
- BRCA gene mutations in cancer
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
King Abdulaziz University
2015-2025
King Abdul Aziz University Hospital
2010-2022
King Abdulaziz Hospital
2022
The University of Texas Southwestern Medical Center
2015
Turku University Hospital
2005-2012
University of Turku
1999-2012
Misurata University
2012
Al-Arab Medical University
2008
Cancer Society of Finland
2008
McMaster University Medical Centre
2008
To study the diagnosis delay and its impact on stage of disease among women with breast cancer Libya.200 women, aged 22 to 75 years diagnosed during 2008-2009 were interviewed about period from first symptoms final histological cancer. This (diagnosis time) was categorized into 3 periods: <3 months, 3-6 >6 months. If time longer than considered delayed delay). Consultation taken visit general practitioner after symptoms. Retrospective preclinical clinical data collected a form...
Abstract Background Although the primary objective of forensic DNA analyses unidentified human remains is positive identification, cases involving historical or archaeological skeletal often lack reference samples for comparison. Massively parallel sequencing (MPS) offers an opportunity to provide biometric data in such cases, and these valuable on feasibility applying MPS characterization modern casework samples. In this study, was used characterize 140-year-old discovered at a site...
Prognostic factors in organ confined prostate cancer will reflect survival after surgical radical prostatectomy. Gleason score, tumour volume, margins and Ki-67 index have the most significant prognosticators. Also origins from transitional zone, p53 status tissue, stage, aneuploidy shown prognostic significance. Progression-associated features include capsular invasion, but PSA is also highly significant. Progression can be predicted with biological markers (E-cadherin, microvessel density,...
Extracellular matrix degradation is required for invasion and metastasis formation in colorectal carcinoma (CRC), therefore, we have examined metalloproteinases MMP-9 expression tumors from patients with CRC. The study comprises of 360 who underwent bowel resection stage II, III, IV tumors. Paraffin-embedded CRC tissue samples were used immunohistochemical staining. Negative levels correlated longer survival time as evaluated by disease-free disease-specific (p =.023, p =.006). In...
Increased mesenchymal–epithelial transition factor gene (c-MET) expression in several human malignancies is related to increased tumour progression. The aim of the present study explore relationship between immunohistochemical c-MET colorectal carcinoma (CRC) and clinicopathological characteristics follow up data, compare primary CRC its metastasis lymph nodes test validity as independent prognostic factor. Hundred thirty-five archival nodal metastases samples were collected from King...
Biobanks and biospecimen collections are becoming a primary means of delivering personalized diagnostics tailoring individualized therapeutics. This shift towards precision medicine (PM) requires interactions among variety stakeholders, including the public, patients, healthcare providers, government, donors. Very few studies have investigated role students in biobanking donations. The main aims this study were (1) to evaluate knowledge senior about biobanks (2) assess students' willingness...
Aim: To evaluate the expression pattern of matrix metalloproteinases (MMPs); MMP-2, MMP-7 and MMP-9 in colorectal cancer (CRC) determine its prognostic potential. Patients & methods: CRC samples 127 patients were studied. Protein expressions -7 -9 analyzed by immunohistochemistry association with clinicopathological variables was statistically analyzed. Results: Overexpressions MMP-2 correlated poor outcome as evaluated univariate Kaplan–Meier for disease-free survival (p = 0.04, p 0.0001)...
Her2/neu is an oncogene that plays important role in the pathogenesis of many cancer types. In bladder carcinoma (BC), clinical significance status remains under-investigated and poorly linked to patients' clinic-pathological features survival status. Thus, current study was conducted assess a cohort Saudi Arabia, explore its prognostic value BC. A total 160 consent patients transitional cell (TCC) were arranged on tissue microarray (TMA) stained by immunohistochemistry (IHC) bright-field...
Background: The mammalian NAD-dependent deacetylase sirtuin-1 family (named also silent information regulator or SIRT family, where NAD stands for “nicotinamide adenine dinucleotide” (NAD)) appears to have a dual role in several human cancers by modulating cell proliferation and death. This study examines how SIRT1 protein levels correlate with clinicopathological characteristics survival outcomes patients breast cancer. Methods: A total of 407 BC formalin-fixed paraffin-embedded (FFPE)...
The present study evaluated the incidence of breast cancer in Libya and described clinicopathological demographic features. These features were then compared with corresponding data from patients sub-Saharan Africa (Nigeria) Europe (Finland). consisted 234 carcinoma, admitted to African Oncology Institute Sabratha, Libya, during years 2002-2006. pathological collected pathology reports, patient histories hospital files Sabratha Cancer Registry. differences between Libyan, Nigerian Finnish...
The present study investigated the associations of serum carcinoembryonic antigen (CEA) and carbohydrate 19-9 (CA19-9) levels with clinicopathological variables survival outcomes in Libyan patients pancreatic ductal adenocarcinoma (PDAC). 123 PDAC registered at National Cancer Institute Misurata, Libya, between 2010 2018 were retrospectively analyzed. Blood samples from these analyzed for CEA CA19-9 before treatment by electrochemiluminescence immunoassay (double antibody sandwich ELISA) on...
AIM:To investigate the changing pattern of β-catenin expression and its prognostic value in advanced colorectal cancer (CRC).METHODS: Archival tumor samples were analyzed for using immunohistochemistry (IHC) 95 patients with CRC.RESULTS: Membranous was found normal epithelium.Almost 1 0 % o f C R c a s e h w d m b ra n u cytoplasmic expression, 55 (58%) cases showed nuclear expression.In univariate (Kaplan-Meier) survival analysis, only index (NI) significant predictor disease-free (DFS) (P...
We have generated a series of isogenically derived immortalized human colonic epithelial cell (HCEC 1CT and HCEC 2CT) lines, including parental un-immortalized normal strains. The CDK4 hTERT line 1CT) is initially karyotypically diploid expresses markers stem markers. Under stressful tissue culture conditions, spontaneous aneuploidy event occurred in the line, resulting single chromosomal change leading to stable trisomy 7 (1CT7). Trisomy occurs about 40% all benign adenomas (polyps) thus...
Background:We evaluated the association of immunohistochemical Ki-67 expression, and S-phase fraction with clinicopathological variables patient outcome.Patients methods: Histological samples from 100 primary Libyan breast carcinoma patients were retrospectively studied monoclonal antibody to Ki-67.S-phase was determined by DNA image cytometry.Results: The median percentage for all tumors 27.5%, ranging 1 80% (SPF) 11%, 0 62 %.Tumors high expression found in 76% SPF values 56%.Ki-67 more...
Elzagheid A, Buhmeida Laato M, El‐Faitori O, Syrjänen K, Collan Y, Pyrhönen S. Loss of E‐cadherin expression predicts disease recurrence and shorter survival in colorectal carcinoma. APMIS 2012; 120: 539–48. The traditional staging system is currently inadequate for identifying those patients with carcinoma (CRC) who carry a high risk poor outcome. In this study, the was evaluated CRC to determine its correlation clinico‐pathological variables, association outcome long‐term follow‐up....
Breast cancer incidence rates are increasing at an alarming rate among Saudi Arabian females. Most molecular genetic discoveries on breast and other cancers have arisen from studies examining European American patients. However, possibility of specific changes in signature patients diverse ethnic groups remains largely unexplored. We performed transcriptomic profiling surgically-resected tumors 45 based the Western region Arabia using Affymetrix Gene 1.0 ST chip. Pathway biological...
Colorectal cancer (CRC) is a heterogeneous disease with different molecular characteristics associated many variables such as the sites from which tumors originate or presence absence of chromosomal instability. Identification variables, particularly mutational hotspots, often carries significant diagnostic and/or prognostic value that could ultimately affect therapeutic outcome. High-throughput analysis 99 CRC formalin-fixed and paraffin-embedded (FFPE) cases was performed using Cancer...
Renal cell carcinoma (RCC) is a seventh ranked malignancy with poor prognosis. RCC lethal at metastatic stage as it does not respond to conventional systemic treatments, and there an urgent need find out promising novel biomarkers for effective treatment. The goal of this study was evaluate the that can be potential therapeutic target predict inhibitors treat RCC.We conducted transcriptomic profiling identify differentially expressed genes associated RCC. Molecular pathway analysis done...