A5051344670- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Emergency and Acute Care Studies
- Cancer Treatment and Pharmacology
- BRCA gene mutations in cancer
- Cancer-related gene regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biomedical Text Mining and Ontologies
- Neutropenia and Cancer Infections
- Lymphadenopathy Diagnosis and Analysis
- Nanoparticles: synthesis and applications
- Cancer therapeutics and mechanisms
- Fibroblast Growth Factor Research
- Hospital Admissions and Outcomes
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Colorectal and Anal Carcinomas
- Immune cells in cancer
- Global Cancer Incidence and Screening
- Mechanisms of cancer metastasis
- Cancer, Hypoxia, and Metabolism
- Brain Metastases and Treatment
King Abdulaziz University
2016-2025
Weatherford College
2022
King Abdul Aziz University Hospital
2014-2020
King Abdulaziz Hospital
2014-2019
King Abdullah University Hospital
2018
Western University
2011
This cross-sectional study is aimed at assessing the quality of life in a cohort breast cancer patients Oncology Department, King Abdulaziz University Hospital (KAUH), (KAU), Jeddah, Saudi Arabia (SA), and to differentiate QoL among different groups. Mean time since diagnosis was 3.97±1.90 years. European Organization for Research Treatment Cancer Quality Life Questionnaires—Core30 BR23 (EORTC QLQ-C30 & BR23) were used assess survivors. ANOVA independent t-test (parametric tests) categorical...
This work described the one-pot synthesis of apple pectin encapsulated Fe3O4 nanoparticles (Fe3O4/Pectin NPs) which is prepared by co-precipitation Fe(II/(III) ions in alkaline solution mediated under ultrasound condition. process led to formation magnetic within network pectin. Physicochemical characterization as-synthesized Fe3O4/Pectin NPs was carried out through electron microscopy (SEM and TEM), energy dispersive X-ray spectroscopy (EDX), vibrating sample magnetometer (VSM) diffraction...
The significance of histological grading and peritumoral edema (PTE) in predicting intracranial meningioma recurrence among Saudis is often neglected. This study aimed to evaluate the impact these factors over a 10-year follow-up period. A retrospective cohort 124 patients with was analyzed period from 2011 2021. All underwent gross total resection (GTR) tumor. Post-surgical radiotherapy (RT) offered grade II-III meningiomas. grading, PTE, RT on recurrence-free interval (RFI) investigated....
Breast cancer (BC) is a multifaceted disease distinguished by range of molecular subtypes and varying clinical prognoses. The involvement DNA methylation in the dysregulation gene expression has been linked to development progression BC. Therefore, this study aimed investigate association between ANGPT1 BC patients. Eight Saudi female blood samples were used undergo for whole genome bisulfite sequencing (WGBS) RNA identification novel targets. Several public domain datasets including...
Colorectal cancer (CRC) is a heterogeneous disease with different molecular characteristics associated many variables such as the sites from which tumors originate or presence absence of chromosomal instability. Identification variables, particularly mutational hotspots, often carries significant diagnostic and/or prognostic value that could ultimately affect therapeutic outcome. High-throughput analysis 99 CRC formalin-fixed and paraffin-embedded (FFPE) cases was performed using Cancer...
The efficacy of adjuvant chemotherapy with fec-d (5-fluorouracil-epirubicin-cyclophosphamide followed by docetaxel) is superior to that fec-100 alone in women early-stage breast cancer. As the use increased clinical practice, health care providers anecdotally noted higher-than-expected toxicity rates and frequent early treatment discontinuations because toxicity. In present study, we compared serious adverse events patients who received routine practice reported pacs-01 trial.We...
Invasive ductal carcinoma of the breast is most common cancer affecting women worldwide. The marked heterogeneity matched only with in its associated or causative factors. Breast Saudi Arabia apparently an early onset many affected females diagnosed before they reach age 50 years. One possible rationale underlying this observation that consanguinity, which widely spread community, causing accumulation yet undetermined susceptibility mutations. Another factor could be epigenetic aberrations...
Identifying and distinguishing cancer driver genes among thousands of candidate mutations remains a major challenge. Accurate identification is critical for advancing research personalizing treatment based on accurate stratification patients. Due to inter-tumor genetic heterogeneity many within gene occur at low frequencies, which make it challenging distinguish them from non-driver mutations. We have developed novel method identifying genes. Our approach utilizes multiple complementary...
Regarding applicative, facile, green chemical research, a bio-inspired approach is being reported for the sonochemical synthesis of Ag nanoparticles by gelatin as natural reducing/stabilizing and solid support agent without using any toxic harmful reagent. The biosynthesized [email protected] bionanocomposite were characterized advanced physicochemical techniques like ultraviolet–visible (UV–Vis), Fourier Transformed Infrared spectroscopy (FT-IR), Scanning Electron Microscopy (SEM),...
Tumor suppressor (p53) acts to integrate multiple stress signals into diverse antiproliferative responses. Its potential transactivate or downregulate genes through apoptotic pathway in IDH-wildtype glioblastoma has never been explored. A group of twenty patients diagnosed with glioblastoma, were tested for p53 expression and NDRG2/NRF2 activity protein gene profiling assays. The connotation between these elements mean patients' age was 64-years. All tumors IDH-wildtype. expressed 12 absent...
Abstract Objectives Protein Arginine Methyltransferase 5 ( PRMT5 ) is an enzyme that regulates gene expression and protein function through arginine methylation. Its association with isocitrate dehydrogenase (IDH) mutation in Grade-4 astrocytoma was rarely investigated. Our aim to explore the between IDH its effect on tumor recurrence. Methods A retrospective cohort of 34 patients Grade 4 has been tested for using arrays. The impact IDH-mutation recurrence explored. Results IDH-wildtype...
Molecular profiling and functional assessment of signalling pathways advanced solid tumours are becoming increasingly available. However, their clinical utility in guiding patients' treatment remains unknown. Here, we assessed whether molecular helps physicians therapeutic decision making by analysing the profiles 1057 cancer patient samples after failing at least one standard care using a combination next-generation sequencing (NGS), immunohistochemistry (IHC) other specific tests. The...
Background: Breast cancer is one of the most common malignancies among women. Recent studies revealed that differentially methylated regions (DMRs) are implicated in regulating gene expression. The goal this research was to determine which genes and pathways dysregulated breast when their promoters an abnormal way, leading differential Whole-genome bisulfite sequencing applied analyze DMRs for eight peripheral blood samples collected from five Saudi females diagnosed with stages I II aligned...
Colorectal Cancer (CRC) is a global medical challenge.In the KSA, it 1 st cancer among males, 3 rd females, with death rate of 8.3%.The main purpose CRC screening to detect in early stage where cure can be achieved.So, this study aimed at evaluating public awareness and determining preferred methods conduct concept.A cross-sectional was performed Jeddah, 2019.Data collection done using an online questionnaire that distributed through social media.4090 participants from all over Kingdom were...
Nasopharyngeal cancer (NPC) is the most common head and neck in Saudi Arabia. This study reports locoregional disease control survival outcomes patients with NPC treated King Abdulaziz University Hospital.Patients for between June 2007 October 2014 were retrospectively reviewed. Demographic information, clinicopathologic variables, chemotherapy data collected analyzed. Cumulative rates calculated by Kaplan-Meier product-limit actuarial method.Thirty-nine Thirty-five (90%) received definitive...
This study applied a structural equation modeling (SEM) to evaluate the role of substance use (alcohol, smoking, and trado-medicine use) changes in liver enzymes (AST, ALT, ALP) levels HIV-infected adult patients on highly active antiretroviral treatment (HAART) for not <1 year. The was cross-sectional, part randomized comparative trial (Ref: UPH/CEREMAD/REC/19), involving 129 (46 males 83 females) patients. Liver enzyme were determined from analyzed blood samples using Clinical Chemistry...
Tumor-associated macrophages (TAMs) are principal immune cells in glioma microenvironment which support tumor growth and proliferation. Our aim this study was to assess the relationship between CD204-expressed TAMs O6-methylguanine-DNA methyltransferase (MGMT)-promoter methylation World Health Organization (WHO) grade 4 astrocytomas, its impact on patient's clinical outcome.The expression of CD204 + quantitively assessed 45 samples WHO astrocytomas using immunohistochemistry. MGMT-promoter...
Do not resuscitate (DNR) is an order in medical practice for the patients who are suffering from a grave condition, and their life danger to end. DNR decision-making varies one hospital another. This study aimed assess knowledge of patients' relatives about concept opinion decision-making.
BACKGROUND: Oral tongue squamous cell carcinoma (OTSCC) is a highly aggressive malignancy characterized by frequent recurrence, poor survival with relatively few therapeutic options due to the late diagnosis in many cases. OBJECTIVES: Understanding molecular pathways underlying OTSCC tumourigen esis and discovery of diagnostic and/or prognostic biomarkers. METHODS: We performed high-throughput mutational analysis 44 formalin-fixed paraffin-embedded (FFPE) cases using Cancer Hotspots Panel...
The underlying mechanism of fibroblast growth factor receptor 1 (FGFR1) mediated carcinogenesis is still not fully understood. For instance, FGFR1 upregulation leads to endocrine therapy resistance in breast cancer patients. current study aimed identify FGFR1-linked genes devise improved therapeutic strategies. RNA-seq and microarray expression data 1,425 patients from two independent cohorts were downloaded for the analysis. Gene Set Enrichment Analysis (GSEA) was performed differentially...
Background: With 748,300 new cases diagnosed every year, hepatocellular carcinoma (HCC) is the 5th and 7th most common cancer among males females, respectively, causes 7% of all cancer-related deaths. HCC represents more than 90% primary liver cancers. Objective: The aim present study was to recognize stages at presentation in patients who were King Abdul Aziz University Hospital (KAUH) identify associated laboratory features advance HCC. Materials Methods: A retrospective analysis 57...
NDRG2 is a tumour suppressor gene involved in tumor growth inhibition. Its effect on recurrence remains controversial. The aim of this study to explore the dual IDH mutation and dysregulation WHO-Grade 4 astrocytoma recurrence.A group 36 patients with were examined for expression using protein assays. relationship between IDH, expressions, recurrence-free interval [RFI] was explored.The mean age 45-years 21 males 15 females. mutant 22 tumors. low 23 tumors, high 13 upregulated tumors 32...