A5011553618- Epigenetics and DNA Methylation
- Marine Sponges and Natural Products
- RNA modifications and cancer
- Autism Spectrum Disorder Research
- Microbial Natural Products and Biosynthesis
- Nanoparticles: synthesis and applications
- Genetics and Neurodevelopmental Disorders
- Bee Products Chemical Analysis
- Traditional and Medicinal Uses of Annonaceae
- Seaweed-derived Bioactive Compounds
- Sesquiterpenes and Asteraceae Studies
- RNA and protein synthesis mechanisms
- Phytochemistry and Biological Activities
- Gut microbiota and health
- Moringa oleifera research and applications
- Wound Healing and Treatments
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Gene expression and cancer classification
- Peroxisome Proliferator-Activated Receptors
- Marine Biology and Environmental Chemistry
- Genomic variations and chromosomal abnormalities
- Nicotinic Acetylcholine Receptors Study
- Plant Diversity and Evolution
- Laser-Ablation Synthesis of Nanoparticles
King Abdulaziz University
2017-2025
Princess Nourah bint Abdulrahman University
2019
Abstract Applying extracts from plants is considered a safe approach in biomedicine and bio-nanotechnology. The present report the first study that evaluated seeds of Lasiurus scindicus Panicum turgidum as biogenic agents synthesis silver nanoparticles (AgNPs) which had bioactivity against cancer cells bacteria. Assessment NPs activity varied cell lines (colorectal HCT116 breast MDA MBA 231 MCF 10A used control) was performed beside antibacterial efficiency. Different techniques (DLS, TEM,...
Introduction: Cadmium (Cd) is a harmful heavy metal that results in many toxic issues. Urtica pilulifera showed potential pharmaceutical applications. This study investigated the possible ameliorative mechanism of leaves extract (UPLE) against hepatotoxicity induced by cadmium chloride (CdCl 2 ) mice. Methods: In vitro phytochemical screening and metal-chelating activity UPLE were ascertained. Four groups forty male mice used ( n = 10) as follows; Group 1 (G1) was negative control. G2...
Breast cancer (BC) is a multifaceted disease distinguished by range of molecular subtypes and varying clinical prognoses. The involvement DNA methylation in the dysregulation gene expression has been linked to development progression BC. Therefore, this study aimed investigate association between ANGPT1 BC patients. Eight Saudi female blood samples were used undergo for whole genome bisulfite sequencing (WGBS) RNA identification novel targets. Several public domain datasets including...
Breast cancer (BC) is the most common malignancy worldwide, including in Saudi Arabia. Because of its heterogeneous nature, existing diagnostic and prognostic biomarkers are not relevant for all cases. There a need to discover novel early diagnosis prognosis reduce mortality. Herein, we utilized an integrative bioinformatics approach identify potential BC. Gene expression profiling 45 BC five normal samples from KAUH, Jeddah was done with GeneChip Human Genome 1.0 ST Array. Data analyzed by...
Abstract Doxorubicin (DOX) is used to treat a variety of malignancies; however, its cardiotoxicity limits effectiveness. Shikimic acid (SA) showed several promising biomedical applications. This study investigated the protective effect SA on DOX-induced in male rats. The ADMETlab 2.0 web server was predict pharmacokinetic properties SA. Molecular docking studies were conducted using AutoDock Vina. Fifty rats divided into 4 groups ( n = 10); G1 negative control; G2 injected with mg/kg DOX...
Green approaches to nanoparticle synthesis offer sustainable and environmentally friendly alternatives, avoiding hazardous chemicals typical in traditional methods. This study characterizes nanoparticles (NPs) synthesized from silver nitrate (AgNO3) iron oxide (Fe2O3) using commercial honey as a reducing capping agent. Characterization revealed significant disparities between NPs (AgNPs) (FeNPs). AgNPs had larger particle size (Z-average: 3115.67 nm) compared FeNPs 1813 nm). showed...
<b>Background and Objective:</b> The remarkable surface-to-volume ratio efficient particle interaction capabilities of nanoparticles have garnered significant attention among researchers. Microalgal synthesis presents a sustainable cost-effective approach to nanoparticle production, particularly noteworthy for its high metal uptake ion reduction capabilities. This study focuses on the eco-friendly straightforward Silver (AgNPs) Iron (FeNPs) by utilizing Spirulina...
Chromatographic fractionation of the CH2Cl2/MeOH extract Red Sea red alga Laurencia obtusa gave two new hexahydrofuro[3,2-b]furan-based C15-acetogenins, namely, isolaurenidificin (1) and bromlaurenidificin (2). The chemical structures were elucidated based on extensive analyses their spectral data. Compounds 1 2 showed no toxicity (LC50 > 12 mM) using Artemia salina as test organism. Both compounds weak cytotoxicity against A549, HepG-2, HCT116, MCF-7, PC-3 cells, however, they exhibited...
Background: Breast cancer is one of the most common malignancies among women. Recent studies revealed that differentially methylated regions (DMRs) are implicated in regulating gene expression. The goal this research was to determine which genes and pathways dysregulated breast when their promoters an abnormal way, leading differential Whole-genome bisulfite sequencing applied analyze DMRs for eight peripheral blood samples collected from five Saudi females diagnosed with stages I II aligned...
Nanoparticles such as carbon nanotubes (CNTs) have various clinical and diagnostic applications utilised for imaging drug delivery. Therapeutic proteins/peptides can be loaded on CNT coronas to specifically hit immune cells in overdrive or uncontrolled malignant cells. Previously, it was reported that a recombinant version of human surfactant protein D (rfhSP-D) containing trimeric C-type lectin domains induced apoptosis several tumour cells/cell lines, including SKOV3, which is an ovarian...
Chromatographic investigation of the aerial parts Rhazya stricta (Apocynaceae) resulted in isolation two new monoterpene indole alkaloids, 6-nor-antirhine-N1-methyl (1) and razyamide (2), along with six known compounds, eburenine (3), epi-rhazyaminine (4), rhazizine (5), 20-epi-sitsirikine (6), antirhine (7), 16-epi-stemmadenine-N-oxide (8). The chemical structures were established by various spectroscopic experiments. Compounds 1-8 exhibited cytotoxic effects against three cancer cells IC50...
Background: DNA methylation (DNAm) is one of the main epigenetic mechanisms that affects gene expression without changing underlying sequence. Aberrant DNAm has an implication in different human diseases such as cancer, schizophrenia, and autism spectrum disorder (ASD). ASD a neurodevelopmental behavior, learning, communication skills. Acyl-CoA synthetase family member 3 ( ACSF3 ) encodes malonyl-CoA involved synthesis oxidation fatty acids. The dysregulation been reported combined malonic...
Abstract Purification of the organic extract Laurencia obtusa Lamouroux by column chromatography and preparative thin layer provided four new compounds: a eudesmane-type sesquiterpenoid [eudesma-4(15),11-diene-5,7-diol ( 1 )], cuparane-type [10-hydroxycuparaldehyde 2 two nor -cuparanes [3-hydroxy-15- -cuparan-10β-ol 3 ) 2-bromo-3-hydroxy-15- 4 )]. Structural identification was made possible comparison spectral data with those reported in literature. Compounds are significant as rarely...
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Introduction: Autism spectrum disorder (ASD) is a developmental that can cause substantial social, communication, and behavioral challenges. Genetic factors play significant role in ASD, where the risk of ASD has been increased for unclear reasons. Twin studies have shown important evidence both genetic environmental contributions level contribution these not proven yet. It suggested copy number variation (CNV) duplication deletion many genes chromosome 22 (Ch22) may strong association with...
Bacterial cellulose (BC) stands out as a prominent biopolymer of global importance, distinguished by its unique advantages over plant-derived cellulose. Strains such Acetobacter xylinum, renowned for their proficient BC production, draw considerable attention in both commercial and biomedical areas. This research aimed to selectively isolate cellulose-producing bacteria with enhanced efficiency from variety fruit samples utilizing cost-effective methodology. A total 60 were selected, the...