A5005764434- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Metal complexes synthesis and properties
- Nanoparticles: synthesis and applications
- Computational Drug Discovery Methods
- Multicomponent Synthesis of Heterocycles
- Nanoparticle-Based Drug Delivery
- Synthesis of Organic Compounds
- Free Radicals and Antioxidants
- Natural product bioactivities and synthesis
- Bioactive Compounds and Antitumor Agents
- Graphene and Nanomaterials Applications
- Essential Oils and Antimicrobial Activity
- Click Chemistry and Applications
- Phytochemicals and Antioxidant Activities
- Traditional and Medicinal Uses of Annonaceae
- Cancer therapeutics and mechanisms
- Phytochemistry and Biological Activities
- Advanced Drug Delivery Systems
- Curcumin's Biomedical Applications
- Phytochemical compounds biological activities
- Phytochemistry and Bioactivity Studies
- Biochemical and Molecular Research
- Natural Antidiabetic Agents Studies
- Moringa oleifera research and applications
King Khalid University
2016-2025
Pirogov Russian National Research Medical University
2023
Microbial L-asparaginase (ASNase) is an important anticancer agent that used extensively worldwide. In this study, 40 bacterial isolates were obtained from the Red Sea of Saudi Arabia and screened for ASNase production using a qualitative rapid plate assay, 28 which producing large L-asparagine hydrolysis zones. The immobilized cells was more favorable than freely suspended cells. A promising isolate, KKU-KH14, identified by 16S rRNA gene sequencing as Bacillus licheniformis. Maximal...
Brain tumor (BTs) is considered one of the deadly, destructive, and belligerent disease, that shortens average life span patients. Patients with misdiagnosed insufficient medical treatment BTs have less chance survival. For analysis, magnetic resonance imaging (MRI) often utilized. However, due to vast data produced by MRI, manual segmentation in a reasonable period time difficult, which limits application standard criteria clinical practice. So, efficient automated techniques are required....
Abstract The present study was carried out in Hayat Abad Industrial Estate located Peshawar to assess the levels of cadmium (Cd) that were soil as well plant parts (Roots and shoots). To evaluate phytoremediation potential plants different factors i.e. Bioconcentration Factor (BCF), Translocation (TF), Bioaccumulation Coefficient determined. These grown their native habitats (BAC). We have analysed, concentration from which are collected 50 locations ranged 11.54 mg/Kg (the lowest) 89.80...
Semisynthetic modifications of natural products have bestowed us with many anticancer drugs. In the present work, a product, eugenol, has been modified synthetically to generate new agents. The final compounds were structurally confirmed by NMR, IR, and mass techniques. From cytotoxicity results, compound 17 bearing morpholine was found be most active cytotoxic agent IC50 1.71 (MCF-7), 1.84 (SKOV3), 1.1 μM (PC-3) thymidylate synthase (TS) inhibitor an 0.81 μM. Further cellular studies showed...
In the present study, binding affinity of 52 bioactive secondary metabolites from Wedelia trilobata towards anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein (PDB: 2W3L) structure was identified by using in silico molecular docking and dynamics simulation. The results demonstrated that energies docked compounds with Bcl-2 ranged −5.3 kcal/mol to −10.1 kcal/mol. However, lowest energy (−10.1 kcal/mol) offered Friedelin against when compared other standard drug Obatoclax (−8.4 kcal/mol)....
Lung cancer (LC) incidence is rising globally and reflected as a leading cause of cancer-associated deaths. leads to multistage carcinogenesis with gradually increasing genetic epigenetic changes.
Senescence is a complicated, multi-factorial, irreversible cell cycle halt that has tumor-suppressing effect in addition to being significant factor aging and neurological diseases. Damaged DNA, neuroinflammation, oxidative stress disrupted proteostasis are few of the factors cause senescence. triggered by DNA damage which initiates response. The response, includes formation foci containing activated H2AX, key cellular senescence, provoked double strand break. Oxidative impairs cognition,...
Combining sonochemistry with phytochemistry is a modern trend in the biosynthesis of metallic nanoparticles (NPs), which contributes to sustainability chemical processes and minimizes hazardous effects.
A new series of pyrazole 4⁻7 and pyrazolo[1,5-a]pyrimidine 8⁻13 were synthesized by using a simple, efficient procedure, screened for their in-vitro antimicrobial antitumor activities. Symmetrical asymmetrical 3,6-diarylazo-2,5,7-triaminopyrazolo[1,5-a]pyrimidine the conventional method also subjected to microwave irradiation under ultrasound conditions. The biological results revealed that most tested compounds proved be active as antibacterial antifungal agents. activity was evaluated...
This study aimed to evaluate and compare the therapeutic effect of camel milk exosomes derived from colostrum, early, mid, late lactation periods on liver cancer HepaRG cells. These showed cytotoxicity while being safer normal human THLE-2 Among four different isolated exosome groups, colostrum exhibited highest apoptotic potential as indicated by DNA damage upregulated expression Bax caspase3 expression, but with lowest Bcl2 expression. HepaRG-treated colostrum-derived also...
A library of novel naproxen based 1,3,4-oxadiazole derivatives (8–16 and 19–26) has been synthesized screened for cytotoxicity as EGFR inhibitors. Among the hybrids, compound2-(4-((5-((S)-1-(2-methoxynaphthalen-6-yl)ethyl)-1,3,4-oxadiazol-2-ylthio)methyl)-1H-1,2,3-triazol-1-yl)phenol(15) was most potent compound against MCF-7 HepG2cancer cells with IC50 2.13 1.63 µg/mL, respectively, equipotent to doxorubicin (IC50 1.62 µg/mL) towards HepG2. Furthermore, 15 inhibited kinase 0.41 μM compared...
The condensation of (1H-benzimidazole-2-yl) methanamine, with 2-hydroxy naphthaldehyde lead to Schiff base ligand (H2L) (1). This was later reacted metal salts (ZnCl2, CrCl3·6H2O, and MnCl2·4H2O) afford the corresponding complexes. Biological activity findings indicate that complexes have promising against Escherichia coli Bacillus subtilis modest Aspergillus niger. in vitro anticancer activities Zn (II), Cr (III), Mn (II) were investigated best results observed complex as most potent...