A5050059268- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Bioactive Compounds and Antitumor Agents
- Plant-derived Lignans Synthesis and Bioactivity
- Phagocytosis and Immune Regulation
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Chemotherapy-induced organ toxicity mitigation
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Gynecological conditions and treatments
- Nanoplatforms for cancer theranostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Neurogenetic and Muscular Disorders Research
- Neonatal Health and Biochemistry
- Cholesterol and Lipid Metabolism
- Flavonoids in Medical Research
- Cancer, Lipids, and Metabolism
- Phytochemicals and Antioxidant Activities
- Phytochemistry and Biological Activities
- Stress Responses and Cortisol
- Chemotherapy-induced cardiotoxicity and mitigation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pregnancy-related medical research
Johns Hopkins Medicine
2023-2024
Johns Hopkins University
2023-2024
Port Said University
2020-2024
Alexandria University
2022
Delta University for Science and Technology
2015-2017
Al-Azhar University
2011
October 6 University
2010
National Organization for Drug Control and Research
1997
Acute lung injury (ALI) is one the most common causes of morbidity and mortality in critically ill patients. In this study, we examined for first time role dapagliflozin (DPGZ) lipopolysaccharide (LPS)-induced ALI rats determined underlying molecular mechanisms by evaluating effects DPGZ on adenosine monophosphate kinase (AMPK), nuclear transcription factor kappa B, nucleotide-binding oligomerization domain-like receptor 3 inflammasome activation. Treatment acute injured with either low dose...
Inflammasome targeting and controlling dysbiosis are promising therapeutic approaches to control ulcerative colitis. This report is the first investigate mechanisms underlying coloprotective effects of rosuvastatin Lactobacillus their combined therapy on dextran sodium sulfate (DSS)-induced colitis in high-fat diet (HFD)-fed rats. Our results demonstrate aggravation intestinal inflammation as a consequence an HFD following DSS administration. An association between dyslipidemia, LDL...
Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. It was suggested that albendazole (ABZ) powerful inhibitor several types. However, the bioavailability ABZ very poor. Additionally, mechanisms underlying antitumor effects may go beyond its tubulin-inhibiting activity. Therefore, we aimed to examine suspension (i.p. and p.o.) ABZ-loaded cubosomes (LC) on diethylnitrosamine-induced HCC in mice. nanoparticles exhibited mean particle size 48.17 ± 0.65 nm...
The purpose of this article is to review the effects four commonly consumed beverage types—sugar-sweetened beverages (SSBs), caffeinated beverages, green tea, and alcohol—on five common benign gynecological conditions: uterine fibroids, endometriosis, polycystic ovary syndrome (PCOS), anovulatory infertility, primary dysmenorrhea (PD). Here we outline a plethora research, highlighting studies that demonstrate possible associations between intake increased risk certain conditions—such as SSBs...
Doxorubicin (DOX; Adricin) is an anthracycline antibiotic, which efficient anticancer chemotherapeutic agent that targets many types of adult and pediatric tumors, such as breast cancer, leukemia, lymphomas. However, use DOX limited due to its cardiotoxic effects. This study sequentially investigated the mechanistic pathways process in rats at different post-treatment periods using cumulative dose, used therapeutic regimes. In this regard, 56 male albino were for experiment. The experimental...
Breast cancer is the most common malignancy worldwide; therefore, development of new anticancer agents essential for improved tumor control. By adopting pharmacophore hybridization approach, two series 7-hydroxyl-4-methylcoumarin hybridized with thiosemicarbazone (V-VI) and thiazolidin-4-one moieties (VII-VIII) were prepared. The in vitro activity was assessed against MCF-7 cells MTT assay. Nine compounds showed significant cytotoxicity. promising compound, VIIb, induced remarkable...
A new series of 2,4-disubstituted benzo[g]quinoxaline molecules have been synthesized, using naphthalene-2,3-diamine and 1,4-dibromonaphthalene-2,3-diamine as the key starting materials. The structures compounds were confirmed by spectral data along with elemental microanalyses. cytotoxic activity all synthesized derivatives was assessed in vitro against breast MCF-7 cancer cell line. tested revealed good cytotoxicity toward line, especially compound 3. results topoisomerase IIβ inhibition...
The present study aims at evaluating potential of the ethanol extracts L. camara leaves (LE), flowers (FlE) and roots (RE) in treatment renal calculi characterising secondary metabolites active extract. results revealed that FlE had significantly reduced levels kidney parameters (calcium, creatinine, urea, uric acid) against ethylene glycol (EG) injuries, restored activity glutathione peroxidase (GPx), superoxide dismutase lipid peroxide malondialdehyde to normal level. In addition,...
A new first series from 2-substituted quinoxalines (3-6) were synthesized using o-phenylenediamine with aryl bromomethyl ketones as a key starting material. Moreover, second 2-oxo-1,2,3,4-tetrahydro-benzo [g] quinoxaline (8-10) obtained the reaction of naphthalene-2,3-diamine ethyl chloroacetate. The structures two compound types confirmed by spectral data studies along elemental microanalysis. cytotoxic effects compounds tested MTT colorimetric assay in MCF-7 cells. Four compounds, given...
Mohamed Sadek Abdel-Bakky, Gouda Kamel Helal, El-Sayed El-Sayed, Elham Amin, Abdulmajeed Alqasoumi, Ahmad Alhowail, Eman Sayed Said Abdelmoti, and Ahmed Saad Saad. Korean J Physiol Pharmacol 2021;25:385-93. https://doi.org/10.4196/kjpp.2021.25.5.385
Background: Red blood cell breakdown creates bilirubin.Red unconjugated (indirect) bilirubin, which circulates mostly bound to albumin although some is free and hence able enter the brain.Unconjugated bilirubin metabolized by liver conjugated then excreted in stool.Since 1960s, phototherapy has treated neonatal hyperbilirubinemia.The treatment improved as light sources strategy for using these have been optimized.Phototherapy replaces exchange transfusions due its efficacy...