A5086866699- Nanoparticle-Based Drug Delivery
- Diet, Metabolism, and Disease
- Muscle Physiology and Disorders
- Nanoparticles: synthesis and applications
- RNA Interference and Gene Delivery
- Dietary Effects on Health
- Graphene and Nanomaterials Applications
- Phytochemistry and Biological Activities
- Mesenchymal stem cell research
- Advanced Drug Delivery Systems
- Curcumin's Biomedical Applications
- Pharmaceutical Practices and Patient Outcomes
- Nanoplatforms for cancer theranostics
- Diabetes Management and Research
- Diet and metabolism studies
- Tissue Engineering and Regenerative Medicine
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- MicroRNA in disease regulation
- Saffron Plant Research Studies
- Bioactive Compounds and Antitumor Agents
- Nigella sativa pharmacological applications
- Telomeres, Telomerase, and Senescence
- Hedgehog Signaling Pathway Studies
- Pluripotent Stem Cells Research
Qassim University
2015-2024
Buraydah Colleges
2024
Universiti Teknologi MARA
2020
Dean College
2019
King's College London
2010-2013
Abstract Zinc oxide-silver (ZnO–Ag), and zinc oxide-gold (ZnO–Au) nano-composites were prepared through wet chemical process laced into single-walled carbon nanotubes (SWCNTs) to yield ZnO–Ag-SWCNTs, ZnO–Au-SWCNTs hybrids. These nano-composite-laced SWCNTs hybrids characterized using Raman spectroscopic, X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission (TEM) analyses. The evaluated for their effects on phagocytic cells bactericidal activity against the gram-negative...
Aims: To evaluate the anti breast-cancer activity, biocompatibility and toxicity of poly(d,l)-lactic-co-glycolic acid (PLGA)-encapsulated quercetin nanoparticles (Q-PLGA-NPs). Materials & methods: Quercetin was nano-encapsulated by an emulsion-diffusion process, were fully characterized through Fourier transform infrared spectroscopy, x-ray diffractions, FESEM zeta-sizer analysis. Activity against CAL51 MCF7 cell lines assessed DNA fragmentation assays, fluorescence microscopy,...
Zygophyllum coccineum, an edible halophytic plant, is part of the traditional medicine chest in Mediterranean region for symptomatic relief diabetes, hypertension, wound healing, burns, infections, and rheumatoid arthritis pain. The current study aimed to characterize Z. coccineum phytoconstituents, evaluations anti-microbial-biofilm, anti-cancers bioactivities plant’s mother liquor, i.e., aqueous-ethanolic extract, its subsequent fractions. silico receptors interaction feasibility major...
Acute lung injury (ALI) is one the most common causes of morbidity and mortality in critically ill patients. In this study, we examined for first time role dapagliflozin (DPGZ) lipopolysaccharide (LPS)-induced ALI rats determined underlying molecular mechanisms by evaluating effects DPGZ on adenosine monophosphate kinase (AMPK), nuclear transcription factor kappa B, nucleotide-binding oligomerization domain-like receptor 3 inflammasome activation. Treatment acute injured with either low dose...
The treatment of breast cancer requires long chemotherapy management, which is accompanied by severe side effects. Localized delivery anticancer drugs helps to increase the drug concentration at site action and overcome such a problem. In present study, chitosan hydrogel was prepared for local 5-Fluorouracil. in vitro release behavior investigated activity evaluated against MCF-7 cells using MTT assay. vivo studies were via intra-tumoral injection 5-FU loaded into female rats. results...
The myogenic behaviour of primary human muscle precursor cells (MPCs) obtained from young (aged 20-25 years) and elderly people 67-82 was studied in culture. Cells were compared terms proliferation, DNA damage, time course extent marker expression during differentiation, fusion, size the formed myotubes, secretion regulatory cytokine TGF-β1 sensitivity to treatment. No differences observed between people. cell populations expanded culture until replicative senescence. Cultures that...
Cancer is one of the leading causes death worldwide. In many cases, cancer related to elevated expression a significant cytokine known as tumor necrosis factor-α (TNF-α). Breast in particular linked increased proliferation cells, high incidence malignancies, more metastases, and generally poor prognosis for patient. The research sought assess effect silver nanoparticles reduced with ethyl cellulose polymer (AgNPs-EC) on TNF-α MCF-7 human breast cells.The AgNPs-EC were produced using green...
Liver fibrosis is a disease with great global health and economic burden. Existing data highlights itraconazole (ITRCZ) as potentially effective anti-fibrotic therapy. However, ITRCZ effect hindered by several limitations, such poor solubility bioavailability. This study aimed to formulate optimize chitosan nanoparticles (Cht NPs) loaded new strategy for managing liver fibrosis. ITRCZ-Cht NPs were optimized utilizing developed 2
The nuclear factor kappa-B (NF-κB) is a major transcription responsible for the production of numerous inflammatory mediators, including tumor necrosis (TNFα), which has lethal association with cancer's onset. silver nanoparticles (AgNPs) are widely used in cancer treatment and several other biomedical applications.The study aimed to determine effects citrate (AgNPs-CIT) on NF-κB activation together TNFα mRNA/protein expressions phorbol myristate acetate (PMA)-stimulated MCF-7 human breast...
Four halophytic plants, Lycium shawii, Anabasis articulata, Rumex vesicarius, and Zilla spinosa, growing in the central Qassim area, Saudi Arabia, were phytochemically biologically investigated. Their hydroalcoholic extracts' UPLC-ESIQ-TOF analyses demonstrated presence of 44 compounds phenolic acids, flavonoids, saponins, carbohydrates, fatty acids chemical classes. Among all plants' extracts, L. shawii showed highest quantities total phenolics, flavonoids contents (52.72 13.01 mg/gm gallic...
Allium cepa L ( A. ) extract is frequently used as an adjuvant food in cancer treatment. We hypothesized that it contains a source of anticancer activity. There need to synthesize the silver nanoparticles (AgNPs) using environment‐friendly green synthesis reduction method aqueous . The AgNPs‐CEPA were prepared by formed characterized for their sizes and charge distribution. AgNP‐CEPA was investigated its antioxidant properties. Cell viability evaluated MTT assay. Gene expression real‐time...
Urinary catheter infections remain an issue for many patients and can complicate their health status, especially individuals who require long-term catheterization. Catheters be colonized by biofilm-forming bacteria resistant to the administered antibiotics. Therefore, this study aimed investigate efficacy of silver nanoparticles (AgNPs) stabilized with different polymeric materials generated via a one-step simple coating technique ability inhibit biofilm formation on urinary catheters. AgNPs...
The current study aimed to investigate the phytochemical contents and antioxidant, antimicrobial, antibiofilm activities of four halophytic plants, namely, Euphorbia chamaesyce, Bassia arabica, Fagonia mollis, Haloxylon salicornicum, native central Saudi Arabia. alcoholic extract E. chamaesyce was found be most potent in various bioactivities-based evaluations rich polyphenols flavonoid secondary metabolites, with 68.0 mg/g 39.23 gallic acid quercetin equivalents, respectively. Among all...
The aim of the present study was to assess short-term effects Thymoquinone (TQ) on oxidative stress, glycaemic control, and renal functions in diabetic rats. DM induced groups II III with a single dose streptozotocin (STZ), while group I received no medication (control). rats were then given distilled water, TQ at 50 mg/kg body weight/day for 4 weeks. Lipid peroxidase, nitric oxide (NO), total antioxidant capacity (TAC), glycated haemoglobin (HbA1c), lipid profiles, function assessed....
Pulmonary fibrosis (PF) is a chronic progressive disease that portends very poor prognosis. It has been suggested STAT3 potential target in PF. This study highlights the importance of cubosomes as drug delivery system enhancing bioavailability nifuroxazide (NXZD), poorly soluble inhibitor. NXZD-loaded (NXZD-LC) were vitro and vivo evaluated. In vitro, presented poly-angular nanosized particles with mean size zeta 223.73 ± 4.73 nm - 20.93 2.38 mV, respectively. The entrapment efficiency was...
Tumor necrosis factor (TNF-α) and inflammatory cytokine (IL-6) play a vital role in various cellular incidents such as the proliferation death of cells during carcinogenesis. Hence, regulation these biomarkers could be promising tool for controlling tumor progression using nanoformulations. Silver nanoparticles-poly (vinyl pyrrolidone) (AgNPs-PVP) were prepared reduction silver nitrate stabilized with PVP. They are characterized through yield percentage, UV-VIS, FT-IR, size, charge,...
Abstract Drug uptake and distribution through cell–receptor interactions are of prime interest in reducing the adverse effects increasing therapeutic effectiveness delivered formulations. This study aimed to formulate silver nanoparticles (AgNPs) conjugated somatostatin analogs for specific delivery receptors (SSTRs) expressed on cells by nebulizing prepared AgNPs formulations into lung vivo application. were using citrate reduction method, yielding AgNPs–CTT, which was further chemically...
Liver malignancy is well recognized as a prominent health concern, with numerous treatment options available. Natural products are considered renewable source, providing inspiring chemical moieties that could be used for cancer treatment. Suaeda vermiculata Forssk has traditionally been employed management of hepatic conditions, including liver inflammation, and cirrhosis, to improve general function. The findings our earlier study demonstrated encouraging in vivo hepatoprotective benefits...
Type 2 diabetes is a chronic condition that requires pharmacotherapy interventions. Metformin and gliclazide are widely used drugs in monotherapy. However, their complementary action made utilization of the combination these an appealing approach.The study compared major therapeutic potentials combined metformin/gliclazide treatment over metformin monotherapy based on following parameters: oxidative stress, lipid profile, hepatorenal functions.This comparative was conducted from March 2015...
Abstract Sorafenib (SFB) is an anticancer drug with sparingly water solubility and reduced bioavailability. Nanoformulation of SFB can increase its dissolution rate solubility. The current study aimed to formulate in nanoparticles improve their sorafenib (SFB-PNs) were synthesized using the solvent evaporation method, then evaluated for particle size, polydispersity index (PDI), zeta-potential, morphological structure, entrapment efficiency (EE%). Further, efficacy A549 Michigan Cancer...