A5009055174- Cancer-related cognitive impairment studies
- Glioma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Metabolism, Diabetes, and Cancer
- Brain Metastases and Treatment
- Diet and metabolism studies
- Phytochemicals and Medicinal Plants
- Chemotherapy-induced organ toxicity mitigation
- Pharmacological Effects and Toxicity Studies
- Intensive Care Unit Cognitive Disorders
- Medicinal Plants and Neuroprotection
- Cancer, Stress, Anesthesia, and Immune Response
- Alcohol Consumption and Health Effects
- Drug-Induced Hepatotoxicity and Protection
- Birth, Development, and Health
- Cholinesterase and Neurodegenerative Diseases
- Nanoparticles: synthesis and applications
- Essential Oils and Antimicrobial Activity
- Diet, Metabolism, and Disease
- Synthesis and biological activity
- Cannabis and Cannabinoid Research
Qassim University
2019-2024
Auburn University
2016-2023
Zagazig University
2023
Walker (United States)
2016
Cognitive deficits are commonly reported by patients following treatment with chemotherapeutic agents. Anthracycline-containing chemotherapy regimens associated cognitive impairment and reductions in neuronal connectivity cancer survivors, doxorubicin (Dox) is a used anthracycline. Although it has been that Dox distribution to the central nervous system (CNS) limited, considerable concentrations observed brain co-administration of certain medications. Additionally, pro-inflammatory...
The nuclear factor kappa-B (NF-κB) is a major transcription responsible for the production of numerous inflammatory mediators, including tumor necrosis (TNFα), which has lethal association with cancer's onset. silver nanoparticles (AgNPs) are widely used in cancer treatment and several other biomedical applications.The study aimed to determine effects citrate (AgNPs-CIT) on NF-κB activation together TNFα mRNA/protein expressions phorbol myristate acetate (PMA)-stimulated MCF-7 human breast...
Background: This study is designed to discover a method for delivering an efficient potent pheophytin (pheo-a) into more absorbed and small polymeric ethyl cellulose (EC) microparticles. Methods: Silica gel Sephadex LH-20 columns were used isolate pheo-a from the chloroform extract of edible plant, Suaeda vermiculata. Pheo-a was incorporated EC microparticles using emulsion-solvent techniques. The antioxidant activity confirmed by level superoxide radical (SOD), nitric oxide (NO), reducing...
Anthocyanins are antioxidant compounds constitute the primary dyes of pomegranate arils. could protect aged skin induced by oxidant exposure as a major role in aging processing and degeneration.The study aimed to evaluate anti-aging activity anthocyanins rich (Punica granatum) after formulated into topical cream. Also, its effect on human dermal fibroblast function epidermal keratinocyte were evaluated.Anthocyanins extracted from fresh arils using acidified methanol purified Sephadex LH-20...
Methotrexate (MTX; 4-amino-10-methylfolic acid) is a folic acid reductase inhibitor used to treat autoimmune diseases and certain types of cancer. Testicular toxicity resulting from MTX significant side effect that may cause subsequent infertility. The present study was conducted examine the ameliorating effects vitamin B17 (VitB17) against testicular induced by in male rats. A total 50 albino rats were equally divided into five groups [control group; group administered VitB17 only;...
Cognitive decline is one of the serious complications associated with diabetes mellitus (T2DM) type-2. In this reported work, effect aqueous sukkari dates seed extract (ASSE) was evaluated in T2DM-induced rats. T2DM induced using intraperitoneal injection nicotinamide and streptozocin (STZ) administration. The diabetic rats were then treated orally 200 mg/kg 400 for 30 days results compared metformin-treated groups. memory functions assessed three maze models. Glucose insulin levels blood...
The aim of the present investigation is to prepare baricitinib (BAR)-loaded diphenyl carbonate (DPC) β-cyclodextrin (βCD) based nanosponges (NSs) improve oral bioavailability.BAR-loaded DPC-crosslinked βCD NSs (B-DCNs) were prepared by varying molar ratio βCD: DPC (1:1.5 1:6). developed B-DCNs loaded with BAR characterized for particle size, polydispersity index (PDI), zeta potential (ZP), % yield and percent entrapment efficiency (%EE).Based on above evaluations, BAR-loaded (B-CDN3) was...
Doxorubicin (DOX) is widely used to treat many types of cancer; however, it associated with chemotherapy-related complications such as cognitive dysfunction, known chemobrain. Chemobrain affects up 75% cancer survivors, and there are currently no available therapeutic options. This study aims examine whether metformin (MET) can protect against the neurotoxicity caused by DOX treatment. Forty male rats were divided into four groups (10 rats/group): control, DOX, + MET, MET. Rats treated...
Salsola cyclophylla, an edible halophyte, is traditionally used for inflammation and pain. To confirm the claimed anti-inflammatory analgesic properties, a detailed study on respective pharmacological actions was undertaken. The activities are contemplated to arise from its phytoconstituents. LC-MS analysis of S. cyclophylla 95% aqueous-ethanolic extract revealed presence 52 compounds belonging phenols, flavonoids, coumarins, aliphatics class. A high concentration Mn, Fe, Zn detected by...
Chemotherapeutic agents such as doxorubicin, cyclophosphamide, fluorouracil, and cisplatin are commonly used to treat a variety of cancers often result in chemobrain, which manifests difficulties learning memory processes that can persist the years following treatment. The current study aims evaluate cognitive function treatment with these underlying mechanisms using rat model neuroinflammation possible implication thyroid toxicity chemotherapy induced dysfunction. Wistar female rats were...
Doxorubicin (DOX) is a chemotherapeutic agent that linked with complications such as cardiotoxicity and cognitive dysfunction, known chemobrain. Chemobrain affects up to 75% of cancer survivors, there are no therapeutic options for its treatment. This study aimed determine the protective effect pioglitazone (PIO) against DOX-induced impairment. Forty Wistar female rats were equally divided into four groups: control, DOX-treated, PIO-treated, DOX + PIO-treated. was administered at dose 5...
Objective Cyclophosphamide (CYP) is a chemotherapeutic agent that widely used as an adjuvant cancer treatment. Unfortunately, this drug associated with secondary side effects, including cognitive impairment up to 70% of survivors. The mechanism memory unclear. Thus, understand the impairments caused by agent, clinically relevant dose treatment was in mice establish chemobrain models, and spatial these assessed using multiple behavior tests. In addition, metformin (MET) anti-diabetic protects...
The current study primarily focused on the pharmacognostical and phytochemical screening of Canna indica further analyzing leaves extract for toxicological profile neuroprotective potential. microscopic, dry powder properties leaf material phytochemical, physicochemical analysis was evaluated assessment. Dry C. were extracted using methanol then studied both in vitro vivo study. acute toxicity measured by estimating antioxidant defense system anatomical impairment rat's organs. Also,...
A common environmental pollutant, lead can induce toxicity in several organ systems. range of industrial and/or household materials and products contain lead, food/liquid ingestion inhalation are the mechanisms through which is introduced into human body.
Abstract Drug uptake and distribution through cell–receptor interactions are of prime interest in reducing the adverse effects increasing therapeutic effectiveness delivered formulations. This study aimed to formulate silver nanoparticles (AgNPs) conjugated somatostatin analogs for specific delivery receptors (SSTRs) expressed on cells by nebulizing prepared AgNPs formulations into lung vivo application. were using citrate reduction method, yielding AgNPs–CTT, which was further chemically...
Doxorubicin (DOX) causes cognitive impairment (chemobrain) in patients with cancer. While DOX damages the cholinergic system, few studies have focused on protective effects of function chemobrain. The acetylcholinesterase inhibitor galantamine (GAL) demonstrates neuroprotective properties. We investigated mechanisms associated DOX-induced impairments and potential role GAL preventing chemobrain.Female Wistar rats were divided into control, DOX, GAL, + groups. group administered (5 mg/kg...
Peripheral infections increase the propensity and severity of seizures in susceptible populations. We have previously shown that intraperitoneal injection a viral mimic, polyinosinic-polycytidylic acid (PIC), elicits hypersusceptibility mice to kainic (KA)-induced seizures. This study was undertaken determine whether this seizure entails alterations glutamate signaling. Female C57BL/6 were intraperitoneally injected with PIC, after 24 h, homeostasis hippocampus monitored using enzyme-based...