A5001517819- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Natural Antidiabetic Agents Studies
- Computational Drug Discovery Methods
- Click Chemistry and Applications
- Enzyme function and inhibition
- Microbial Applications in Construction Materials
- Cholinesterase and Neurodegenerative Diseases
- Carbohydrate Chemistry and Synthesis
- Biochemical and Molecular Research
- Enzyme Production and Characterization
- Synthesis of Organic Compounds
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation
- Multicomponent Synthesis of Heterocycles
- Quinazolinone synthesis and applications
- Phytochemicals and Antioxidant Activities
- Free Radicals and Antioxidants
- Advanced Glycation End Products research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Fungal Plant Pathogen Control
- Enzyme Catalysis and Immobilization
- Research on Leishmaniasis Studies
- Psidium guajava Extracts and Applications
- Synthesis of Indole Derivatives
University of Karachi
2015-2024
International Center for Chemical and Biological Sciences
2015-2024
Inhibiting α-glucosidase is a reliable method for reducing blood sugar levels in diabetic individuals. Bis(dimethylamino)benzophenone derivatives 1–27 were synthesized from bis(dimethylamino)benzophenone via two-step reaction. Different spectroscopic techniques, including EI-MS and 1H NMR, employed to characterize all synthetic derivatives. The elemental composition of compounds was confirmed by analysis results found agreement with the calculated values. evaluated inhibitory activity,...
Abstract Current research is based on the identification of novel inhibitors α -amylase enzyme. For that purpose, new hybrid molecules hydrazinyl thiazole substituted chromones 5 – 27 were synthesized by multi-step reaction and fully characterized various spectroscopic techniques such as EI-MS, HREI-MS, 1 H-NMR 13 C-NMR. Stereochemistry iminic bond was confirmed NOESY analysis a representative molecule. All compounds 5–27 along with their intervening intermediates 1–4 , screened for in vitro...
Background: Despite many side effects associated, there are drugs which being clinically used for the treatment of type-II diabetes mellitus (DM). In this scenario, is still need to develop new therapeutic agents with more efficacy and less effects. By keeping in mind diverse spectrum biological potential associated coumarin thiazole, a hybrid class based on these two heterocycles was synthesized. Method: Hydrazinyl thiazole substituted coumarins 4-20 were synthesized via step reaction....