A5091044841- Synthesis and biological activity
- Enzyme function and inhibition
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Protein Interaction Studies and Fluorescence Analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Quinazolinone synthesis and applications
- Free Radicals and Antioxidants
- Synthesis and Catalytic Reactions
- Catalytic Cross-Coupling Reactions
- Porphyrin and Phthalocyanine Chemistry
- DNA and Nucleic Acid Chemistry
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Advanced biosensing and bioanalysis techniques
- Phenothiazines and Benzothiazines Synthesis and Activities
- Click Chemistry and Applications
- Electrochemical sensors and biosensors
- Multicomponent Synthesis of Heterocycles
- Biochemical and Molecular Research
- Drug Transport and Resistance Mechanisms
Gaziantep University
2014-2024
Ardahan University
2023
Hacettepe University
2006-2009
SARS-CoV-2 is a new generation of coronavirus, which was first determined in Wuhan, China, December 2019. So far, however, there no effective treatment has been found to stop this coronavirus but discovering the crystal structure main protease (SARS-CoV-2 Mpro) may facilitate searching for therapies SARS-COV-2. The aim assess effectiveness available FDA approved drugs can construct covalent bond with Cys145 inside binding site by using docking screening. We conducted covdock module MMGBSA...
In this work, we report in-depth computational studies of three plausible tautomeric forms, generated through the migration two acidic protons N4-hydroxylcytosine fragment, molnupiravir, which is emerging as an efficient drug to treat COVID-19. The DFT calculations were performed verify structure these tautomers, well their electronic and optical properties. Molecular docking was applied examine influence structures keto-oxime, keto-hydroxylamine hydroxyl-oxime tautomers on a series...
A novel infectious agent, SARS-CoV-2, is responsible for causing the severe respiratory disease COVID-19 and death in humans. Spike glycoprotein plays a key role viral particles entering host cells, mediating receptor recognition membrane fusion, are considered useful targets antiviral vaccine candidates. Therefore, computational techniques can be used to design safe, antigenic, immunogenic, stable against this pathogen. Drawing upon structure of S glycoprotein, we trying develop potent...
The widespread emergence of antimalarial drug resistance has created a major threat to public health. Malaria is life-threatening infectious disease caused by Plasmodium spp., which includes Apicoplast DNA polymerase and falciparum cysteine protease falcipain-2. These components play critical role in their life cycle metabolic pathway, are involved the breakdown erythrocyte hemoglobin host, making them promising targets for anti-malarial design. Our current study been designed explore...
Abstract In this study, it was planned to synthesize new members of fenamate isosteres and investigate its effect on some metabolic enzymes such as Acetylcholinesterase, Butyrylcholinesterase, α‐Glucosidase, Carbonic andyhrase I–II. The target compounds were obtained from the reaction N ‐subtituted anthranilic hydrazides with sulfonylated aldehyde derivatives. structures characterized using Fourier‐transform Infrared, Nuclear Magnetic Resonance, High‐resolution Mass Spectroscopy. Compounds...
Pandemic COVID-19 infections have spread throughout the world. There is no effective treatment against this disease. Viral RNA-dependent RNA polymerase (RdRp) catalyzes replication of from and main protease (Mpro) has a role in processing polyproteins that are translated SARS-CoV-2, thus these two enzymes strong candidates for targeting by anti-viral drugs. Small molecules such as lopinavir favipiravir significantly inhibit activity Mpro RdRp vitro. Studies shown structurally modified...
This study was designed to determine the phytochemical composition of Hypericum scabrum extracts and investigate their biologically prominent activities. LC-MS/MS analysis revealed presence 29 phytochemicals in plant extracts. The methanol extract (ME) exhibited strongest DPPH radical scavenging (IC50: 18.57 µg/mL) ferric ion reducing capacity (74.20 mg TEAC/g). Besides, ME displayed most promising α-glycosidase 1.88 acetylcholinesterase AChE 8.41 inhibitory effect. XTT assay results strong...
Type 2 diabetes and obesity-related metabolic diseases have been treated with traditional medicinal plants for centuries. In this study, the effects of Allium kastambulense plant extracts on different enzyme activities were investigated, results added as graphics tables after calculating. This study aimed to identify quantify phenolic composition Bosse determine anti-lipase, anti-urease, anti-melanogenesis, antidiabetic, anti-alzheimer, antibacterial properties. IC50 all enzymes obtained...
Abstract N ‐substitued anthranilic acid derivatives are commonly found in the structure of many biologically active molecules. In this study, new members hydrazones derived from (1−15) were synthesized and investigated their effect on some metabolic enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α‐glycosidase (α‐Gly). Results indicated that all molecules exhibited potent inhibitory effects against targets compared to standard inhibitors, revealed by IC 50 values....