A5055528561- Synthesis and biological activity
- Computational Drug Discovery Methods
- Corrosion Behavior and Inhibition
- Concrete Corrosion and Durability
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis of Organic Compounds
- Hydrogen embrittlement and corrosion behaviors in metals
- Crystal structures of chemical compounds
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Metal complexes synthesis and properties
- Crystallography and molecular interactions
- Quinazolinone synthesis and applications
- Synthesis and Reactions of Organic Compounds
- Plant biochemistry and biosynthesis
- Bioactive Natural Diterpenoids Research
- Essential Oils and Antimicrobial Activity
- Synthesis and Characterization of Pyrroles
- Metal and Thin Film Mechanics
- Synthesis of heterocyclic compounds
- Nonlinear Optical Materials Research
Chouaib Doukkali University
2020-2025
Sidi Mohamed Ben Abdellah University
2015-2023
Small molecules such as 4-phenoxypyridine derivatives have remarkable inhibitory activity against c-Met enzymatic and proliferation of cancer cell lines. Since there is a relationship between structure biological these molecules, little compounds may great potential for clinical pharmaceutical use various types caused by activity. The purpose this study was to remodel the structures achieve strong provide favorable pharmacokinetic properties drug design discovery. Therefore, paper describes...
A series of new heterocycle hybrids incorporating pyrazole and isoxazoline rings was successfully synthesized, characterized, evaluated for their antimicrobial responses. The synthesized compounds were obtained utilizing N-alkylation 1,3-dipolar cycloaddition reactions, as well structures established through spectroscopic methods confirmed by mass spectrometry. To get more light on the regioselective synthesis hybrid compounds, mechanistic studies performed using DFT calculations with...
The abnormal expression of the c-Met tyrosine kinase has been linked to proliferation several human cancer cell lines, including non-small-cell lung (NSCLC). In this context, identification new inhibitors based on heterocyclic small molecules could pave way for development a therapeutic pathway. Using multiple linear regression (MLR)-quantitative structure-activity relationship (QSAR) and artificial neural network (ANN)-QSAR modeling techniques, we look at quantitative between biological...
Green corrosion inhibitors are gaining recognition for their sustainable, cost-effective, and environmentally friendly nature, along with impressive water solubility high inhibition efficiency. They offer a promising solution to combat issues that plague various industries. However, harness the full potential of these eco-friendly inhibitors, profound understanding development underlying mechanisms is essential. This knowledge key paving way next generation protection materials. Herein,...
Coronavirus disease 2019 (COVID-19) is an ongoing pandemic instigated by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) which changed the daily train of world's population and cause several dead. Despite significant efforts made in developing vaccines therapeutic drugs, there currently no available effective treatment against this new coronavirus infection, hence need to continue research aimed at limiting progression virus. The present study has as objective carry out silico studies on...
Novel pyrazoles were synthesized and evaluated for their antimicrobial activity. Molecular docking, 3D-QSAR, drug-likeness property ADME-Tox studies performed.
The search for novel powerful antimicrobial and antioxidant agents is considered a dynamic field in medicinal chemistry. In this context, series of spiropyrazoline indolin-3-one congeners were assessed their vitro bioactivities, in-silico studies conducted to support the experimental results. screening oxindole against selected microbe strains (Staphylococcus aureus (CECT 976), Bacillus subtilis (DSM 6633), Escherichia coli (K12), Candida albicans (ATCC 10231)) exhibited moderate excellent,...
COVID-19 pandemic caused by very severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) agent is an ongoing major global health concern. The disease has more than 452 million affected cases and 6 death worldwide. Hence, there urgency to search for possible medications drug treatments. There are no approved drugs available treat yet, although several vaccine candidates already some of them listed emergency use the world organization (WHO). Identifying a potential candidate may make...
Novel isoxazole–triazole conjugates have been efficiently synthesized using 3-formylchromone as starting material according to a multi-step synthetic approach. The structures of the target and intermediate products were characterized by standard spectroscopic techniques (1H NMR 13C NMR) confirmed mass spectrometry (MS). all-synthesized compounds screened for their antibacterial activity against three ATCC reference strains, namely Staphylococcus aureus 25923, BAA-44, Escherichia coli 25922...