A5009728718- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Computational Drug Discovery Methods
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Carbohydrate Chemistry and Synthesis
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- HIV/AIDS drug development and treatment
- Food Quality and Safety Studies
- Natural Antidiabetic Agents Studies
- Free Radicals and Antioxidants
- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Phytoestrogen effects and research
- Crystallization and Solubility Studies
- Synthesis of β-Lactam Compounds
- Enzyme function and inhibition
Mohamed I University
2022-2023
The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 is one the optimum targets for antiviral drug design and development. hydroxyl groups cytidine structures were modified with different aliphatic aromatic to obtain 5´- O -acyl 2´,3´-di- derivatives, then, these derivatives employed in molecular modeling, prediction, docking, dynamics, pharmacological POM studies. Density functional theory (DFT) at B3LYP/6-31G++ level analyzed biochemical behavior electrostatic potential (MESP)...
Since Schiff base derivatives have a wide range of biological activities, novel were designed and synthesized in satisfactory yields. 1H NMR, 13C IR, mass elemental analysis used to provide complete structural characterization the new bases (3-6). The antiproliferative activity properties compounds tested against two human cancer cell lines including breast (MDA-MB-231) colon (DLD-1). overall did not show high cytotoxic both compared positive control drug cisplatin. further screened for...
The search for novel powerful antimicrobial and antioxidant agents is considered a dynamic field in medicinal chemistry. In this context, series of spiropyrazoline indolin-3-one congeners were assessed their vitro bioactivities, in-silico studies conducted to support the experimental results. screening oxindole against selected microbe strains (Staphylococcus aureus (CECT 976), Bacillus subtilis (DSM 6633), Escherichia coli (K12), Candida albicans (ATCC 10231)) exhibited moderate excellent,...
Because of their superior antibacterial and pharmacokinetic capabilities, many nucleoside-based esters show potential against microorganisms, may be used as pharmacological agents to address multidrug-resistant pathogenic problems. In this study, several aliphatic aromatic groups were inserted synthesize various 5'-O-decanoyluridine (2-5) 5'-O-lauroyluridine derivatives (6-7) for antimicrobial, in silico computational, POM (Petra/Osiris/Molinspiration). The chemical structures the...
Nucleoside analogs are an important, well-established class of clinically useful medicinal agents that exhibit potent antimicrobial activity. Thus, we designed to explore the synthesis and spectral characterization 5′-O-(myristoyl)thymidine esters (2–6) for in vitro antimicrobial, molecular docking, dynamics, SAR, POM analyses. An unimolar myristoylation thymidine under controlled conditions furnished it was further converted into four 3′-O-(acyl)-5′-O-(myristoyl)thymidine analogs. The...
The aim of the present research is evaluation extraction process effect on chemical composition, antioxidant activities, and mild steel corrosion inhibition ability Argania spinosa’s extracts (alimentary oil (AO) hexanic extract roasted almonds (HERA)). composition revealed that both have same major compounds: Palmitic, linoleic, stearic acids, with their order slightly different. Electrochemical impedance spectroscopy (EIS), weight loss measurements, polarization curves were used to...
Due to the uneven distribution of glycosidase enzyme expression across bacteria and fungi, glycoside derivatives antimicrobial compounds provide prospective promising materials. Therefore, herein, we report synthesis characterization six novel methyl 4,6-O-benzylidene-α-d-glucopyranoside (MBG) (2-7). The structures were ascertained using spectroscopic techniques elemental analyses. Antimicrobial tests (zone inhibition, MIC MBC) carried out determine their ability inhibit growth different...
The aim of this study is the valorization Argan leaves' Aqueous Extract (ALAE) as a potential industrial alternative for Argania spinosa kernels' extracts.The chemical composition ALAE was investigated by HPLC/UV-VIS/DAD and we successively identified 5 compounds in which quercetin its derivatives represent 85.47%.We also evaluated antioxidant activity via two assays DPPH* scavenging Ferric Reducing Antioxidant Power (FRAP).The concentration required to achieve 50% 142.53±1.26μg/mL...