A5074300836- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Crystal structures of chemical compounds
- Quinazolinone synthesis and applications
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Synthesis of heterocyclic compounds
- Multicomponent Synthesis of Heterocycles
- Polymer Science and PVC
- Phenothiazines and Benzothiazines Synthesis and Activities
- Microtubule and mitosis dynamics
- Crystallography and molecular interactions
- Cancer therapeutics and mechanisms
- Sulfur-Based Synthesis Techniques
- Metal complexes synthesis and properties
- Synthesis and Reactions of Organic Compounds
- Bioactive Compounds and Antitumor Agents
- DNA Repair Mechanisms
- Melanoma and MAPK Pathways
- Polymer Nanocomposites and Properties
- Polymer crystallization and properties
- Synthesis of β-Lactam Compounds
- Essential Oils and Antimicrobial Activity
Shaqra University
2015-2023
University of Sussex
2013-2015
Brighton Hospital
2015
Because of their superior antibacterial and pharmacokinetic capabilities, many nucleoside-based esters show potential against microorganisms, may be used as pharmacological agents to address multidrug-resistant pathogenic problems. In this study, several aliphatic aromatic groups were inserted synthesize various 5'-O-decanoyluridine (2-5) 5'-O-lauroyluridine derivatives (6-7) for antimicrobial, in silico computational, POM (Petra/Osiris/Molinspiration). The chemical structures the...
Poly(vinyl chloride) (PVC) undergoes photodegradation induced by ultraviolet (UV) irradiation; therefore, for outdoor applications, its photostability should be enhanced through the use of additives. Several carvedilol tin complexes were synthesized, characterized and mixed with PVC to produce thin films. These films irradiated at 25 °C a UV light (λ = 313 nm) up 300 h. The reduction in weight changes chemical structure surface morphology monitored. containing synthesized showed less...
This study develops a process for enhancing the photostabilization of PVC films blended with low concentration mefenamate–tin complex. One tri-substituted and three di-substituted organotin complexes containing mefenamate unit are synthesized, their chemical structures established. The reactions mefenamic acid number substituted tin chlorides gave corresponding in 70–77% yields. Tin were thin films. effect addition additives against long-term irradiation (290–400 nm, 300 h) is also tested....
Due to the uneven distribution of glycosidase enzyme expression across bacteria and fungi, glycoside derivatives antimicrobial compounds provide prospective promising materials. Therefore, herein, we report synthesis characterization six novel methyl 4,6-O-benzylidene-α-d-glucopyranoside (MBG) (2-7). The structures were ascertained using spectroscopic techniques elemental analyses. Antimicrobial tests (zone inhibition, MIC MBC) carried out determine their ability inhibit growth different...
Three organosilanes were synthesized in good yields from the condensation of 4,4′,4″-((phenylsilanetriyl)tris(oxy))tribenzaldehyde and 4-substituted anilines under acidic conditions. The structure was confirmed using a variety techniques. Organosilanes mixed with poly(vinyl chloride) (PVC) homogenous films produced. effect long-term irradiation on containing tested various methods. Monitoring infrared spectra PVC before, during after processes showed formation side products comprising...
Environmental problems associated with the growing levels of carbon dioxide in atmosphere due to burning fossil fuels satisfy high demand for energy are a pressing concern. Therefore, design new materials storage has received increasing research attention. In this work, we report synthesis three Schiff bases containing trimethoprim unit and investigation their application as adsorbents capture. The reaction aromatic aldehydes acid medium gave corresponding 83%–87% yields. exhibited surface...
Using acid–base assays and simple slow evaporation method at ambient temperature, we were successful in producing a novel salt with the chemical formula (C5H14N2)[HgCl4]·H2O. According to single-crystal X-ray diffraction data, crystal packing was regulated by H-bonds Coulomb interactions (also called electrostatic interactions) between distinct entities, which formed 3D network. The 2D fingerprint plots Hirshfeld surface utilized examine effect of intermolecular interactions. FTIR...
This review summarizes the synthetic procedures for production of various types triazoloquinoxaline derivatives.Synthesis triazolo[1,5-a]-, triazolo[4,3-a]-, triazolo[4,5-g]-and bis-triazoloquinoxalines are given.The main methods involve diazotization 2-nitroanilines, then reaction with acid chloride derivatives followed by reduction nitro groups and ring closure; closure N-(2-alkynyl)-2-azido-anilines; 2,3-dichloroquinoxalines hydrazides, or hydrazine hydrates carbonyl compounds...
Microwave-assisted synthesis of the pyrazolyl ketone p38 MAPK inhibitor RO3201195 in 7 steps and 15% overall yield, comparison its effect upon proliferation Werner Syndrome cells with a library ketones, strengthens evidence that inhibition plays critical role modulating premature cellular senescence this progeroid syndrome reversal accelerated ageing observed vitro on treatment SB203580.
Curcumin can be isolated from plants (Curcuma longa) and it belongs to the ginger family. It exhibits many useful properties acts as an antioxidant. The aim of current study was prepare eight curcumin analogues investigate their antioxidant activities inhibit thermal degradation low-density polyethylene (LDPE). carbonyl index (CI) measured test effectiveness analogues. Various doses (0.5, 1, 2, 4, 6% wt/wt) a mixture containing LDPE were prepared, CI measured. found have good excellent...
Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including a 2-chloroquinoline with 3-pyridinylboronic acid, coupling an aryl bromide indolylboronic acid and reaction 3-amino-4-bromopyrazole 4-carbamoylphenylboronic acid. In all these processes, was fast relatively efficient using palladium catalyst under microwave irradiation. The process...
GRAPHICAL ABSTRACT
Poly(vinyl chloride) degrades when exposed to ultraviolet light for long durations; therefore, the photostability of polymeric materials should be enhanced through application additives. New organotin complexes containing 4-aminonaphthalene-1-sulfonic acid were synthesized and their role as poly(vinyl photostabilizers evaluated. The reaction 4-amino-3-hydroxynaphthalene-1-sulfonic appropriate di- or trisubstituted tin chloride (triphenyltin chloride, tributyltin dibutyltin dichloride,...
The slow solvent evaporation approach was used to create a single crystal of (C7H6N3O2)2[ZnCl4] at room temperature. Our compound has been investigated by single-crystal XRD which declares that the complex crystallizes in monoclinic crystallographic system with P21/c as space group. molecular arrangement can be described slightly distorted tetrahedral ZnCl42- anionic entities and 5-nitrobenzimidazolium cations, linked together different non-covalent interaction types (H-bonds, Cl…Cl, π…π...
The current work reports the synthesis of novel hydrazones and bis-hydrazones containing 1,2,3-triazole moiety. Base-assisted aldol condensation 4-acetyl-1,2,3-triazole 1a (R = NO2) anisaldehyde (2) gave corresponding chalcone 3 in 88% yield. 4-(1-(2-(2,4-Dinitrophenyl)hydrazineylidene)-3-(4-methoxyphenyl)allyl)-5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazole (5) was synthesized 85% yield from reaction 2,4-dinitrophenylhydrazine (4) boiling ethanol presence a catalytic amount HCl. Condensation...
Abstract C 26 H 17 ClFN 3 OS, monoclinic, P 2 1 / c (no. 14), a = 6.4955(2) Å, b 14.6143(5) 22.6492(8) β 94.568(1)°, V 2143.20(12) Å , Z 4, R gt (F) 0.0461, wR ref (F ) 0.1069, T 100 K.
Abstract C 23 H 17 ClFN 5 S 2 , monoclinic, P 1 / c (no. 14), a = 20.9691(12) Å, b 11.5316(6) 9.2546(4) β 95.484(4)°, V 2227.6(2) Å 3 Z 4, R gt ( F ) 0.0468, wR ref 0.1126, T 296 K.
Abstract C 24 H 16 Br 2 FN 3 S, monoclinic, P 1 / n (no. 14), a = 14.9517(9) Å, b 5.4857(3) c 27.9582(17) β 102.434(6)°, V 2239.4(2) Å , Z 4, R gt ( F ) 0.0444, wR ref 0.1237, T 296 K.
A simple and efficient process for the synthesis of novel heterocycles starting from thiocarbohydrazide was reported. Reaction 2‐acetylbenzofuran ( 1 ) 2 in ethanol containing acetic acid produced corresponding thiocarbohydrazone 3 86% yield. isatin 4 gave N ,2‐bis(2‐oxoindolin‐3‐ylidene)hydrazine‐1‐carbothiohydrazine 6 65% yield, rather than expected product, 3‐[(1‐methyl‐1‐benzofur‐2‐ylmethylidene)amino]‐1‐{[(3 Z )‐2‐oxo‐2,3‐dihydro‐1 H ‐indol‐3‐ylidene]amino}thiourea 5 )....