A5045773881- Computational Drug Discovery Methods
- Synthesis and biological activity
- Essential Oils and Antimicrobial Activity
- SARS-CoV-2 and COVID-19 Research
- Probiotics and Fermented Foods
- vaccines and immunoinformatics approaches
- Legume Nitrogen Fixing Symbiosis
- Bioactive Compounds and Antitumor Agents
- Plant-Microbe Interactions and Immunity
- Pharmacological Effects of Natural Compounds
- Economic Zones and Regional Development
- Enzyme Production and Characterization
- Phytochemistry and Bioactivity Studies
- Microbial Metabolites in Food Biotechnology
- Antimicrobial Peptides and Activities
- Biofuel production and bioconversion
- Phytochemicals and Antioxidant Activities
- Medicinal Plants and Neuroprotection
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Bacteriophages and microbial interactions
- Cross-Border Cooperation and Integration
- Cholinesterase and Neurodegenerative Diseases
- Chromium effects and bioremediation
- Natural Antidiabetic Agents Studies
University of Rajshahi
2014-2025
American University
2024-2025
American InterContinental University
2024-2025
University of Dhaka
2023
Dhaka University of Engineering & Technology
2023
Shahjalal University of Science and Technology
2023
Rajshahi University of Engineering and Technology
2019-2023
Western Sydney University
2023
Bangabandhu Sheikh Mujib Medical University
2023
José Rizal University
2023
The need to develop ecologically friendly sustainable building materials is made apparent by the worldwide construction industry's substantial contribution global greenhouse gas emissions. use of supplemental in concrete one potential solution lessen environmental footprint. Thus, purpose this work Machine Learning (ML) algorithms forecast and create an empirical formula for Compressive Strength (CS) with materials. Six distinct ML models—XGBoost, Linear Regression, Decision Tree, k-Nearest...
The new coronavirus (SARS-CoV-2) halts the world economy and caused unbearable medical emergency due to high transmission rate also no effective vaccine drugs has been developed which brought pandemic situations. main protease (Mpro) of SARS-CoV-2 may act as an target for drug development conservation level. Herein, we have employed a rigorous literature review pipeline enlist 3063 compounds from more than 200 plants Asian region. Therefore, virtual screening procedure helps us shortlist...
The recent coronavirus disease 2019 (COVID-19) pandemic is a global threat for healthcare management and the economic system, effective treatments against pathogenic severe acute respiratory syndrome 2 (SARS-CoV-2) virus responsible this have not yet progressed beyond developmental phases. As drug refinement vaccine progression require enormously broad investments of time, alternative strategies are urgently needed. In study, we examined phytochemicals extracted from Avicennia officinalis...
COVID-19 and its causative organism SARS-CoV2 that emerged from Wuhan city, China have paralyzed the world. With no clinically approved drugs, global health system is struggling to find an effective treatment measure. At this crucial juncture, screening of plant-derived compounds may be strategy combat COVID-19. The present study investigated binding affinity phytocompounds with 3-Chymotrypsin-like (3CLpro) Papain-like proteases (PLpro) using in-silico techniques. A total 32 anti-protease...
Abstract Currently, no approved vaccine is available against the Middle East respiratory syndrome coronavirus (MERS-CoV), which causes severe disease. The spike glycoprotein typically considered a suitable target for MERS-CoV candidates. A computational strategy can be used to design an antigenic pathogen. Therefore, we immunoinformatics and approaches multi-epitope that targets of MERS-CoV. After using numerous tools applying several immune filters, poly-epitope was constructed comprising...
The recent coronavirus outbreak has changed the world's economy and health sectors due to high mortality transmission rates. Because development of new effective vaccines or treatments against virus can take time, an urgent need exists for rapid design drug candidates combat this pathogen. Here, we obtained antiviral peptides from data repository antimicrobial (DRAMP) screened their predicted tertiary structures ability inhibit main protease severe acute respiratory syndrome 2 (SARS-CoV-2)...
Currently, a worldwide pandemic has been declared in response to the spread of coronavirus disease 2019 (COVID-19), fatal and fast-spreading viral infection caused by severe acute respiratory syndrome 2 (SARS-CoV-2). The low availability efficient vaccines treatment options resulted high mortality rate, bringing world economy its knees. Thus, mechanistic investigations drugs capable counteracting this are demand. main protease (Mpro) expressed SARS-CoV-2 targeted for development potential...
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic due to the high transmission and mortality rate this virus. world health economic sectors have been severely affected by deadly virus, exacerbated lack sufficient efficient vaccines. design effective drug candidates their rapid development is necessary combat In study, we selected 23 antimicrobial peptides from literature predicted structure using PEP-FOLD 3.5. addition, docked them SARS-CoV-2...
Degradation of cellulosic carbon, the most important natural carbon reservoirs on this planet by cellulase is very essential for valuable soluble sugars. This has potential biotechnological applications in many industrial sectors. Thus demand increasing more frequently than ever. Agro byproducts and suitable microbes are an source production cellulase. Bacillus pseudomycoides sugarcane bagasse were used different process parameters influencing optimized here. The bacterium showed maximum...
The high transmission and pathogenicity of SARS-CoV-2 has led to a pandemic that halted the world's economy health. newly evolved strains scarcity vaccines worsened situation. main protease (Mpro) can act as potential target due its role in viral replication conservation level.In this study, we have enlisted more than 1100 phytochemicals from Asian plants based on deep literature mining. compounds library was screened against Mpro SARS-CoV-2.The selected three ligands, Flemichin,...
A series of methyl β-D-galactopyranoside (MGP, 1) analogs were selectively acylated with cinnamoyl chloride in anhydrous N,N-dimethylformamide/triethylamine to yield 6-O-substitution products, which was subsequently converted into 2,3,4-tri-O-acyl different acyl halides. Analysis the physicochemical, elemental, and spectroscopic data these revealed their chemical structures. In vitro antimicrobial testing against five bacteria two fungi prediction activity spectra for substances (PASS)...
Piper betle L. is widely distributed and commonly used medicinally important herb. It can also be as a medication for type 2 diabetes patients. In this study, compounds of P. were screened to investigate the inhibitory action alpha-amylase alpha-glucosidase against through molecular docking, dynamics simulation, ADMET (absorption, distribution, metabolism, excretion, toxicity) analysis. The molecule apigenin-7-O-glucoside showed highest binding affinity among 123 (one hundred twenty-three)...
The phytochemicals of medicinal plants are regarded as a rich source diverse chemical spaces that have been used supplements and alternative medicines in the millennium. Even this era combinatorial drugs, phytomedicines account for large share statistics newly approved drugs. In field computational aided rational drug design, there is an urgent need to develop build useful phytochemical database management system with user-friendly interface allows proper data storage, retrieval management....
This investigation Extensively explored the synthesis and potential therapeutic applications of derivatives derived from methyl α-d-mannopyranoside. It encompasses a wide range evaluations, including antimicrobial assessments, molecular docking, dynamic simulations, ADMET analysis. Spectroscopic methods (FTIR, 1H NMR, 13C mass) were used to confirm structures synthesized mannopyranoside derivatives. study assessed antibacterial activity strains against both gram-positive gram-negative...
Newly emerged SARS-CoV-2 made recent pandemic situations across the globe is accountable for countless unwanted death and insufferable panic associated with co-morbidities among mass people. The scarcity of appropriate medical treatment no effective vaccine or medicine against has turned situation worst. Therefore, in this study, we a deep literature review to enlist plant-derived natural compounds considered their binding mechanism main protease through combinatorial bioinformatics...
The recently emerged coronavirus (SARS-CoV-2) has created a crisis in world health, and economic sectors as an effective treatment or vaccine candidates are still developing. Besides, negative results clinical trials cheap solution against this deadly virus have brought new challenges. viral protein, the main protease from SARS-CoV-2, can be effectively targeted due to its replication pathogenesis role. In study, we enlisted 88 peptides AVPdb database. peptide molecules were modeled carry...
The harmful effects of chemical preservatives are driving the need for natural ones. To meet this demand, probiotic lactic acid bacteria (LAB) were isolated from fermented oats in study. goals study to separate and identify LAB oats, determine how effective these at combating pathogenic microorganisms vitro, investigate their preservative capacity by applying bacterium's cell-free supernatant (CFS) specific fruits fruit juice. strain was identified as Lactobacillus plantarum DMR14 using...
Carbonic anhydrase IX (hCAIX) is a membrane-spanning metalloenzyme, encoded by CA9 gene, which can lead to various carcinomas if upregulated. Due its overexpression in many cancer tissues, hCAIX has become promising target for developing anticancer therapeutics. Furthermore, several classes of small-molecules have shown inhibit the expression. In this study, therefore, we screened (n = 42) plant-derived compounds identify most potent inhibitors and understand their interactions with drug...
Background: SYK gene regulates the expression of kinase (Spleen tyrosine kinase), an important non-receptor protein-tyrosine for immunological receptor-mediated signaling, which is also considered a tumor growth metastasis initiator. An onco-informatics analysis was adopted to evaluate and prognostic value in colorectal cancer (CRC), third most fatal type; late, it may be biomarker as another targeted site CRC. In addition, identify potential phytochemicals that inhibit overexpression...
Coronavirus disease 2019 (COVID-19) is a potentially lethal and devastating that has quickly become public health threat worldwide. Due to its high transmission rate, many countries were forced implement lockdown protocols, wreaking havoc on the global economy medical crisis. The main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causative virus for COVID-19, represent an effective target development new drug/vaccine because it well-conserved plays vital...
One of the greatest environmental concerns in world is thought to be effluents from textile industry. The use synthetic dyes textiles makes traditional method treating more difficult. Microorganisms can used remediate damage that do environment. In this investigation, two bacterial strains with capacity degrading dye were isolated waste and identified as Pseudomonas sp. (Accession no. NR 117,678.1) Bacillus no: NR148248.1) through morphological, biochemical, molecular test. cytotoxicity...
The plant growth-boosting biofilm-forming bacteria Bacillus pseudomycoides is able to promote growth and drought stress tolerance in wheat by suppressing the MYB gene, which synthesizes Myb protein (TaMpc1-D4) through secreted volatile compounds. In present study, Triticum aestivum seeds were inoculated with five distinct bacterial strains. growth, germination rate, root-shoot length, RWC, chlorophyll content of seedlings investigated. Furthermore, levels soluble sugars, proteins, H2O2, NO,...
The spread of the Dengue virus over world, as well multiple outbreaks different serotypes, has resulted in a large number deaths and medical emergency, no viable medications to treat patients have yet been found. In this paper, we provide an silico virtual screening molecular dynamics-based analysis uncover efficient infection inhibitors. Based on Google search literature mining, phytochemical library was generated employed ligand molecules. investigation, protein target NS2B/NS3 from...