A5091058426- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Parasite Biology and Host Interactions
- Immunotherapy and Immune Responses
- Computational Drug Discovery Methods
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Helminth infection and control
- Helicobacter pylori-related gastroenterology studies
- Pneumonia and Respiratory Infections
- Hepatitis B Virus Studies
- Influenza Virus Research Studies
- Mycobacterium research and diagnosis
- Veterinary medicine and infectious diseases
- Transgenic Plants and Applications
- Malaria Research and Control
- Genetic factors in colorectal cancer
- Enzyme Structure and Function
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Insect symbiosis and bacterial influences
- Coconut Research and Applications
- Antibiotic Use and Resistance
- Genetic Associations and Epidemiology
- Invertebrate Immune Response Mechanisms
- Escherichia coli research studies
Mawlana Bhashani Science and Technology University
2015-2024
International Centre for Genetic Engineering and Biotechnology
2015
International Centre for Genetic Engineering and Biotechnology
2014
International Centre for Diarrhoeal Disease Research
2009
The recent coronavirus outbreak has changed the world's economy and health sectors due to high mortality transmission rates. Because development of new effective vaccines or treatments against virus can take time, an urgent need exists for rapid design drug candidates combat this pathogen. Here, we obtained antiviral peptides from data repository antimicrobial (DRAMP) screened their predicted tertiary structures ability inhibit main protease severe acute respiratory syndrome 2 (SARS-CoV-2)...
Signal recognition particle (SRP) is a ubiquitous ribonucleoprotein complex that targets proteins to endoplasmic reticulum (ER) in eukaryotes. Here we report Plasmodium falciparum SRP composed of six polypeptides; SRP9, SRP14, SRP19, SRP54, SRP68 and SRP72 303nt long RNA. We generated four transgenic parasite lines expressing SRP-GFP chimeric co-localization studies showed the nucleo-cytoplasmic localization for these proteins. The evaluation effect known nuclear import/export inhibitors on...
Chikungunya virus (CHIKV) instigating fever is a global infective menace resulting in high fever, weakened joint-muscle pain, and brain inflammation. Inaccessibility unavailability of effective drugs have led us to an uncertain arena when it comes providing proper medical treatment the affected people. In this study, authentic encroachment has been made concerning peptide-based epitope vaccine designing against CHIKV. A Proteome-wide search was performed locate conserved portion among...
Shigellosis, a bacillary dysentery, is closely associated with diarrhoea in human and causes infection of 165 million people worldwide per year. Casein-degrading serine protease autotransporter enterobacteriaceae (SPATE) subfamily protein SigA, an outer membrane protein, exerts both cytopathic enterotoxic effects especially to epithelial cell type-2 (HEp-2) shown be highly immunogenic. In the present study, we have tried impose vaccinomics approach for designing common peptide vaccine...
Streptococcus pneumoniae (Pneumococcus) accounts for a major global health burden that causes bacterial pneumonia, sepsis, otitis media, and meningitis. It is responsible great morbidity mortality globally. Available pneumonia vaccines are either carbohydrate-based or not protective against specific serotypes. Besides, antibiotic resistance to pneumococci justifies further attention explore new vaccine candidates. The invariant peptide-based only immunogenic all age groups but also serotypes...
Chikungunya (CHIK) patients may be vulnerable to coronavirus disease (COVID-19). However, presently there are no anti-COVID-19/CHIK therapeutic alternatives available. The purpose of this research was determine the pharmacological mechanism through which kaempferol functions in treatment COVID-19-associated CHIK co-infection. We have used a series network pharmacology and computational analysis-based techniques decipher define binding capacity, biological functions, targets, processes...
Mycoplasma genitalium is a pathogenic microorganism linked to variety of severe health conditions including ovarian cancer, prostate HIV transmission, and sexually transmitted diseases. A more effective approach address the challenges posed by this pathogen, given its high antibiotic resistance rates, could be development peptide vaccine. In study, we used experimentally validated 13 membrane proteins their immunogenicity identify suitable vaccine candidates. Thus, based on immunogenic...
Abstract Background Helicobacter pylori is a highly genetically diverse bacterial species, which can persist in the gastric environment for decades. Recent studies have shown that single infections predominate developed countries, whereas mixed are more prevalent developing countries. Mixed of this bacterium may be important adaptation to hostile and facilitate dyspeptic symptoms. Materials Methods To calculate prevalence symptomatic asymptomatic subjects, 2010 H. isolates collected from 83...
Abstract Novel coronavirus (SARS-CoV-2) leads to disease 19 (COVID-19) recently declared as a pandemic for its outbreak within almost 190 countries worldwide. No effective drugs and/or vaccines authenticated against this rapidly spreading virus till now. This study aims establish an efficient multi-epitope vaccine that could elicit both T-cell and B-cell responses sufficient recognize confirmed surface proteins of the virus. The sequences viral proteins, e.g. envelope protein (E), membrane...
Helicobacter pylori infection is common worldwide and its prevalence higher in the developing countries. Earlier studies using urea breath test showed a high (67%) of H. early childhood Bangladesh. Data on bacterial culture limited The aim study was to investigate Bangladeshi subjects culture. We also determined among different age groups find out correlation between related sociodemographic parameters. A cross-sectional conducted randomly selected households from peri-urban community Dhaka,...
Protein secretion is an essential process in all eukaryotes including organisms belonging to the phylum Apicomplexa, which includes many intracellular parasites. The apicomplexan parasites possess a specialized collection of secretory organelles that release number proteins facilitate invasion host cells and some these also participate immune evasion. Like other eukaryotes, series membrane-bound compartments, namely endoplasmic reticulum (ER), intermediate compartments (IC) or vesicular...
Shigella is a bacterial pathogen that causes shigellosis, fatal bacillary dysentery, responsible for higher level of mortality worldwide. We adopted number computational approaches to predict potential epitope-based vaccine candidates immunogenic proteins spp. selected three cell surface the bacterium according their antigenicity using VaxiJen server, including, FepA, Maltoporin, and OmpW. The sequence analyses by IEDB server resulted in 15-mer peptides core epitope, FTAEHTQSV, FLVNQTLTL,...
The prevalence of self-medication is high in Bangladesh due to easy access and poor regulatory controls over these drugs. Our study aimed assess the attitude university students toward antibiotic usage, especially their knowledge awareness about antibiotics resistance. We also evaluated determinants behind attempts at drug intake without prescription.A cross-sectional was conducted Mawlana Bhashani Science Technology University that included information from randomly selected 200 15...
Ultraviolet radiation causes skin cancer, but the exact mechanism by which it occurs and most effective methods of intervention to prevent are yet unknown. For this purpose, our study will use bioinformatics systems biology approaches discover potential biomarkers cancer for early diagnosis prevention disease with applicable clinical treatments.
Shigellosis is one of the significant causes diarrhea in Bangladesh. It a global health problem; approximately 1.3 million people die yearly from Shigellosis. The current treatment method, using different antibiotics against ineffective. Moreover, it becomes worrying situation due to emergence antibiotic-resistant pathogenic microbes responsible for these diarrheal diseases. Previous immunoinformatics study predicted potential peptide Ferric enterobactin protein (FepA) Shigella spp. In this...
Dengue fever is an acute tropical disease that spread by Aedes species mosquitoes. It a virus-mediated illness causes headaches, fever, severe joint and muscle pain, swollen glands (lymphadenopathy), rashes. Every year, 390 million people around the world suffer from it ∼20 % die cases are left untreated. The virus transmitted to humans mosquito bites of infected species. When gets into body, its envelope protein attaches host cell surface receptor initiates viral infection cycle formation...