A5024881745- Computational Drug Discovery Methods
- Synthesis and biological activity
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- Antimicrobial Peptides and Activities
- Inflammatory mediators and NSAID effects
- Natural Antidiabetic Agents Studies
- COVID-19 Clinical Research Studies
- Bioactive Compounds and Antitumor Agents
- Malaria Research and Control
- Biochemical and Structural Characterization
- Medicinal Plants and Neuroprotection
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Seed and Plant Biochemistry
- Bacteriophages and microbial interactions
- Digital Marketing and Social Media
- Genomics and Rare Diseases
- Diverse Scientific Research Studies
- Protein Structure and Dynamics
- Synthesis of β-Lactam Compounds
- Influenza Virus Research Studies
- Lung Cancer Research Studies
- Aldose Reductase and Taurine
- Chemical synthesis and alkaloids
University of Rajshahi
2020-2025
University of Barisal
2024
The new coronavirus (SARS-CoV-2) halts the world economy and caused unbearable medical emergency due to high transmission rate also no effective vaccine drugs has been developed which brought pandemic situations. main protease (Mpro) of SARS-CoV-2 may act as an target for drug development conservation level. Herein, we have employed a rigorous literature review pipeline enlist 3063 compounds from more than 200 plants Asian region. Therefore, virtual screening procedure helps us shortlist...
Abstract Currently, no approved vaccine is available against the Middle East respiratory syndrome coronavirus (MERS-CoV), which causes severe disease. The spike glycoprotein typically considered a suitable target for MERS-CoV candidates. A computational strategy can be used to design an antigenic pathogen. Therefore, we immunoinformatics and approaches multi-epitope that targets of MERS-CoV. After using numerous tools applying several immune filters, poly-epitope was constructed comprising...
The recent coronavirus outbreak has changed the world's economy and health sectors due to high mortality transmission rates. Because development of new effective vaccines or treatments against virus can take time, an urgent need exists for rapid design drug candidates combat this pathogen. Here, we obtained antiviral peptides from data repository antimicrobial (DRAMP) screened their predicted tertiary structures ability inhibit main protease severe acute respiratory syndrome 2 (SARS-CoV-2)...
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic due to the high transmission and mortality rate this virus. world health economic sectors have been severely affected by deadly virus, exacerbated lack sufficient efficient vaccines. design effective drug candidates their rapid development is necessary combat In study, we selected 23 antimicrobial peptides from literature predicted structure using PEP-FOLD 3.5. addition, docked them SARS-CoV-2...
The phytochemicals of medicinal plants are regarded as a rich source diverse chemical spaces that have been used supplements and alternative medicines in the millennium. Even this era combinatorial drugs, phytomedicines account for large share statistics newly approved drugs. In field computational aided rational drug design, there is an urgent need to develop build useful phytochemical database management system with user-friendly interface allows proper data storage, retrieval management....
This study aims to examine the determinants of brand loyalty in emerging markets, focusing on smartphone consumers Bangladesh. The focuses identifying key elements that contribute and extent their impact customers' commitment preferred manufacturers. A theoretical framework will be employed establish relationship between independent dependent variables. Data for was collected from 390 participants through a Google form explicitly designed this purpose. In Simultaneous Regression Analysis has...
The recently emerged coronavirus (SARS-CoV-2) has created a crisis in world health, and economic sectors as an effective treatment or vaccine candidates are still developing. Besides, negative results clinical trials cheap solution against this deadly virus have brought new challenges. viral protein, the main protease from SARS-CoV-2, can be effectively targeted due to its replication pathogenesis role. In study, we enlisted 88 peptides AVPdb database. peptide molecules were modeled carry...
Because of their superior antibacterial and pharmacokinetic capabilities, many nucleoside-based esters show potential against microorganisms, may be used as pharmacological agents to address multidrug-resistant pathogenic problems. In this study, several aliphatic aromatic groups were inserted synthesize various 5'-O-decanoyluridine (2-5) 5'-O-lauroyluridine derivatives (6-7) for antimicrobial, in silico computational, POM (Petra/Osiris/Molinspiration). The chemical structures the...
Cystatin A (CSTA) functions as a cysteine protease inhibitor by forming tight complexes with the cathepsins. Pathogenic mutations in CSTA gene can disrupt this interaction, potentially leading to physiological ailments. In study, eight bioinformatics tools (SIFT, PolyPhen-2, PROVEAN, P-Mut, MutPred2, SNAP2, SNPs & GO, and PHD-SNP) were implemented analyze non-synonymous from dbSNP database. Five (Y43C, Y43N, V48F, Y53H, E94K) located conserved region found be highly deleterious less...
The spread of the Dengue virus over world, as well multiple outbreaks different serotypes, has resulted in a large number deaths and medical emergency, no viable medications to treat patients have yet been found. In this paper, we provide an silico virtual screening molecular dynamics-based analysis uncover efficient infection inhibitors. Based on Google search literature mining, phytochemical library was generated employed ligand molecules. investigation, protein target NS2B/NS3 from...
Coronavirus disease 2019 (COVID-19) is a potentially lethal and devastating that has quickly become public health threat worldwide. Due to its high transmission rate, many countries were forced implement lockdown protocols, wreaking havoc on the global economy medical crisis. The main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causative virus for COVID-19, represent an effective target development new drug/vaccine because it well-conserved plays vital...
A deadly respiratory disease Middle East Respiratory Syndrome (MERS) is caused by a perilous virus known as MERS-CoV, which has severe impact on human health. Currently, there no approved vaccine, prophylaxis, or antiviral therapeutics for preventing MERS-CoV infection. Due to its inexorable and integral role in the maturation replication of virus, 3C-like protease unavoidly viable therapeutic target. In this study, 2369 phytoconstituents were enlisted from Japanese medicinal plants, these...
Each year thousands of people suffer across the globe due to higher cancer incidence and mortality rates. Additionally, treatment option for patients is also costly, often drugs from lower efficacy with more side effects. The DNA topoisomerase can function as an established target because Human Topoisomerase (Top1) regulates genetic transcription during post-mitotic phase plays a critical role in supercoiling replication repair. Therefore, drug therapy, blocking Top1 may be crucial...
Many of the global pandemics threaten human existence over decades among which coronavirus disease (COVID-19) is newest exposure circulating worldwide. The RNA encoded severe acute respiratory syndrome 2 (SARS-CoV-2) virus referred as pivotal agent this deadly that induces tract infection by interacting host ACE2 receptor with its spike glycoprotein. Rapidly evolving nature modified into new variants helps in perpetrating immune escape and protection against defense mechanism. Consequently,...
The current coronavirus disease 2019 (COVID-19) pandemic, caused by the 2 (SARS-CoV-2), involves severe acute respiratory syndrome and poses unprecedented challenges to global health. Structure-based drug design techniques have been developed targeting main protease of SARS-CoV-2, responsible for viral replication transcription, rapidly identify effective inhibitors therapeutic targets. Herein, we constructed a phytochemical dataset 1154 compounds using deep literature mining explored their...
Typhoid fever caused by the bacteria Salmonella typhi gained resistance through multidrug-resistant S. strains. One of reasons behind β-lactam antibiotic is -lactamase. L, D-Transpeptidases responsible for typhoid as it involved in toxin release that results humans. A molecular modeling study these targeted proteins was carried out various methods, such homology modeling, active site prediction, prediction disease-causing regions, and analyzing potential inhibitory activities curcumin...
Antibiotic-resistant microbes have emerged around the world, presenting a risk to health. Plant-derived drugs become potential source for production of antibiotic-resistant and cancer therapies. In this study, we investigated antibacterial, cytotoxic antioxidant properties Acalypha indica Boerhavia diffusa, conducted in silico molecular docking experiments against EGFR VEGFR-2 proteins. The metabolic extract A. inhibited Streptococcus iniae Staphylococcus sciuri with inhibition zones 21.66 ±...
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used as analgesics, antipyretics, anti-clotting, and agents. One such NSAID, ketoprofen (KTP), is prescribed to treat pain, sprains, menstrual irregularities, osteoarthritis (OA), rheumatoid arthritis (RA). By inhibiting cyclooxygenase, it halts prostaglandin synthesis. However, exhibits significant side effects in humans other living things. Herein, the chemical structure of KTP has been modified search for improved medicinal...
Abstract Background Luciferase is a well-known oxidative enzyme that produces bioluminescence. The Pseudomonas meliae plant pathogen causes wood rot on nectarine and peach possesses luciferase-like monooxygenase. After activation, it bioluminescence, the pathogen’s bioluminescence visual indicator of diseased plants. Methods present study aims to model characterize monooxygenase protein in P. for its similarity well-established luciferase. In this study, from infects chinaberry plants has...