A5007245144- Computational Drug Discovery Methods
- Natural Antidiabetic Agents Studies
- Toxin Mechanisms and Immunotoxins
- Transgenic Plants and Applications
- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Monoclonal and Polyclonal Antibodies Research
- Morinda citrifolia extract uses
- Microbial Metabolism and Applications
- Venomous Animal Envenomation and Studies
- Microbial Natural Products and Biosynthesis
- Drug-Induced Hepatotoxicity and Protection
- Antibiotic Resistance in Bacteria
- Protein Kinase Regulation and GTPase Signaling
- Genomics and Phylogenetic Studies
- Diverse Scientific Research Studies
- Phytochemistry and biological activity of medicinal plants
- Phytochemicals and Antioxidant Activities
- Bacteriophages and microbial interactions
- Chemical synthesis and alkaloids
- Healthcare and Venom Research
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Enzyme Production and Characterization
- Pharmacological Effects of Natural Compounds
University of Rajshahi
2019-2024
The phytochemicals of medicinal plants are regarded as a rich source diverse chemical spaces that have been used supplements and alternative medicines in the millennium. Even this era combinatorial drugs, phytomedicines account for large share statistics newly approved drugs. In field computational aided rational drug design, there is an urgent need to develop build useful phytochemical database management system with user-friendly interface allows proper data storage, retrieval management....
Newly emerged SARS-CoV-2 made recent pandemic situations across the globe is accountable for countless unwanted death and insufferable panic associated with co-morbidities among mass people. The scarcity of appropriate medical treatment no effective vaccine or medicine against has turned situation worst. Therefore, in this study, we a deep literature review to enlist plant-derived natural compounds considered their binding mechanism main protease through combinatorial bioinformatics...
Silver nanoparticles (AgNPs) have sparked widespread interest due to their remarkable physiochemical capabilities, and they are now being used as a beneficial tool in the biomedical area. However, typical synthesis...
Snake venom of Naja naja comprises several types enzymes, and among them, water-soluble proteolytic enzyme, phospholipase A2 (PLA2), is noteworthy for its numerous adverse effects, such as cytotoxicity, cardiotoxicity, hemolytic, anti-coagulant, hypotensive including being highly potent a neurotoxin. Limited anti-venom therapy (with their lower efficacy) has attracted considerable pharmacological interest to develop inhibitors PLA2. Thus, 34 experimentally proven diverse synthetic PLA2 were...
West Nile Virus is a spherical, enveloped capsid with single-stranded RNA molecule and known pathogen responsible for encephalitis. The deficiency of adequate treatment WNV resulted in an increased mortality rate its endemic zones, consequently causing emergence as primary health concern on both national international scales brain inflammation/infections caused by are proved to be lethal. Thus, potential vaccination against the most viable candidate remediation. A multi-epitope...
Nowadays, there has been a significant surge in the exploration of anticancer compounds derived from medicinal plants due to their perceived safety and efficacy. Therefore, our objective was investigate antioxidant antiproliferative properties, along with phytoconstituents, methanol extracts various parts 15 selected Bangladeshi plants. Standard spectrophotometric methods confocal microscopic techniques were adopted assess potentialities extractives. Additionally, phytochemical profiling...
Inhibition of tumor necrosis factor-alpha (TNF-α) has become a feasible target for alleviating inflammation-mediated diseases. Currently, techniques developed, such as anti-TNF antibody therapies, prove not to be nearly beneficial enough effectively treat syndromes because the increased risk severe infections and malignancies. Our study undertaken attempt identifying small molecules inhibit TNF-α. This manually selected 37 plant-derived compounds based on IC50 value from various literature,...
This article reports the Chromobacterium amazonense BASUSDA_45 strain's draft genomic sequence. The bacterium was isolated from cypermethrin pesticide contaminated soil and then sequencing carried out. Initially de novo assembly of raw sequences, trimming quality check generates 125 contigs having N50 78,923. Further mapping generated scaffolds. genome contains 53 scaffolds with a total length 4,295,151 bp 62.30% GC content 3,726,017. Annotation using Prokaryotic Genome Pipeline (PGAP)...
Abstract Targeting apoptosis is a promising approach to inhibit the abnormal cell proliferation of cancer progression. Existing anti-apoptotic drugs, many derived from chemical substances, have often failed combat development and Therefore, identification apoptosis-inducing anticancer agents plant-derived sources has become key aim in research. The present study was designed explore regulation by Tabebuia pallida ( T. ) using an Ehrlich Ascites Carcinoma (EAC) mouse model compositional...
We report the draft genome sequence of Klebsiella pneumoniae strain BASUSDALSc45PDB48, isolated from pesticide-contaminated soil; this showed ability to grow in a medium with cypermethrin as only carbon source. The assembly comprised 5,249,704 bp, 128.17 Ns per 100 kbp, an N50 value 5,035,968 GC content 57.57%, and 5,349 annotated genes.