A5027710608- Plant Molecular Biology Research
- Bioactive Compounds and Antitumor Agents
- Genomics, phytochemicals, and oxidative stress
- Effects of Environmental Stressors on Livestock
- Natural Antidiabetic Agents Studies
- Postharvest Quality and Shelf Life Management
- Plant Physiology and Cultivation Studies
- Photosynthetic Processes and Mechanisms
- Bioactive natural compounds
- Plant Stress Responses and Tolerance
- Phytochemicals and Antioxidant Activities
- Chronic Kidney Disease and Diabetes
- Ferroptosis and cancer prognosis
- Natural Compound Pharmacology Studies
- Endometrial and Cervical Cancer Treatments
- Phytochemistry and biological activity of medicinal plants
- Urban Green Space and Health
- Free Radicals and Antioxidants
- Phytochemistry and Biological Activities
- Complementary and Alternative Medicine Studies
- Plant biochemistry and biosynthesis
- Dialysis and Renal Disease Management
- Phytochemical compounds biological activities
- Synthesis and biological activity
- Antibiotic Resistance in Bacteria
The University of Queensland
2019-2025
Queensland Health
2020-2025
Royal Brisbane and Women's Hospital
2020-2025
Gopalganj Science and Technology University
2013-2024
Liaquat National Hospital
2024
Shaikh Zayed Postgraduate Medical Institute
2023
Abdul Wali Khan University Mardan
2016-2022
Princess Alexandra Hospital
2020-2022
Translational Research Institute
2020-2022
Allama Iqbal Medical College
2022
Abstract The present study was designed to evaluate the antiemetic activity of abietic acid (AA) using in vivo and silico studies. To assess effect, doses 50 mg/kg b.w. copper sulfate (CuSO 4 ⋅5H 2 O) were given orally 2-day-old chicks. test compound at two 20 40 On other hand, aprepitant (16 mg/kg), domperidone (6 diphenhydramine (10 hyoscine (21 ondansetron (5 mg/kg) administered as positive controls (PCs). vehicle used a control group. Combination therapies with referral drugs also three...
Abstract Background Antioxidants play an important role to protect damage caused by oxidative stress (OS). Plants having phenolic contents are reported possess antioxidant properties. The present study was designed investigate the properties and (total phenols, flavonoids, flavonols proanthrocyanidins) of methanolic extracts from Morus alba (locally named as Tut commonly known white mulberry) stem barks (TSB), root bark (TRB), leaves (TL) fruits (TF) make a statistical correlation between...
Summary Rose ( R osa hybrida ) is one of the most important ornamental plants worldwide; however, senescence its petals terminates value flower, resulting in major economic loss. It known that hormones abscisic acid ABA and ethylene promote petal senescence, while gibberellins GA s) delay process. However, molecular mechanisms underlying antagonistic effects amongst plant during are still unclear. Here we isolated RhHB1 , a homeodomain‐leucine zipper I transcription factor gene, from rose...
Gastric cancer is the fourth most commonly diagnosed with second highest mortality rate worldwide. Surgery, chemotherapy and radiation therapy are generally used for treatment of stomach but only limited clinical response shown by these therapies still no effectual advanced gastric adenocarcinoma patients available. Therefore, there a need to identify other therapeutic agents against this life-threatening disease. Plants considered as one important sources development anticancer drugs....
Abstract Background The use of plants and their derived substances increases day by for the discovery therapeutic agents owing to versatile applications. Current research is directed towards finding naturally-occurring antioxidants having anticancer properties from plant origin since oxidants play a crucial role in developing various human diseases. present study was designed investigate antioxidant Sygygium fruticosum (Roxb.) (abbreviated as SF). Methods dried coarse powder seeds SF...
Abstract The pathogenesis of crystal nephropathy involves deposition intratubular crystals, tubular obstruction and cell death. 8-dihydroxyadenine (DHA) crystals within kidney tubules, for instance, is caused by a hereditary deficiency adenine phosphoribosyl transferase in humans or overload preclinical models. However, the downstream pathobiological patterns attrition adenine/DHA-induced remain poorly understood. In this study, we investigated: (i) modes adenine-induced death an...
In this study, the antioxidative fraction of white mulberry (Morus alba) was found to have an apotogenic effect on Ehrlich's ascites carcinoma cell-induced mice (EAC mice) that correlate with upregulated p53 and downregulated NFκB signaling. The antioxidant activities polyphenolic contents various fractions were evaluated by spectrophotometry ethyl acetate (EAF) selected for further analysis. Strikingly, EAF caused 70.20% tumor growth inhibition S-phase cell cycle arrest, normalized blood...
Abstract The availability and use of blinatumomab symbolizes a paradigm shift in the management B-cell acute lymphoblastic leukemia (ALL). We conducted retrospective multicenter cohort analysis 239 ALL patients (227 relapsed refractory [RR], n = 227; minimal residual disease [MRD], 12) who received outside clinical trials to evaluate safety efficacy “real-world” setting. median age at initiation was 48 years (range, 18-85). Sixty-one (26%) had ≥3 prior therapies 46 (19%) allogeneic...
Drought is a major abiotic stress that affects the development and growth of most plants, limits crop yield worldwide. Although response plants to drought has been well documented, much less known about how respond water recovery process, namely rehydration. Here, we describe spatio-temporal plant reproductive organs rehydration using rose flowers as an experimental system. We found triggered rapid transient ethylene production in gynoecia. This burst serves signal ensure flowers, promotes...
Dehydration is a major factor resulting in huge loss from cut flowers during transportation. In the present study, dehydration inhibited petal cell expansion and resulted irregular roses, mimicking ethylene-treated flowers. Among five floral organs, substantially elevated ethylene production sepals, whilst rehydration caused rapid levels gynoecia sepals. biosynthetic enzyme genes (RhACS1–5), expression of RhACS1 RhACS2 was induced by two organs. Silencing both significantly suppressed...
In recent decades, acceptance of nanoparticles (NPs) in therapeutic applications has increased because their outstanding physicochemical features. By overcoming the drawbacks conventional therapy, utilization metal NPs, metal-oxide, or supported nanomaterials have shown to significant medicine. This is proved by a lot clinical and laboratory investigations that show improved treatment outcomes, site-specific drug delivery, fewer side effects compared traditional The NPs interaction with...
To investigate the comparative effects of Diospyros blancoi (Ebenaceae) leaves (DBL), root bark (DBRB) and stem (DBSB) on free radicals cancer. The polyphenol contents, antioxidant radical scavenging properties were determined using standard spectrophotometric methods. Cytotoxicity anticancer activities performed brine shrimp nauplii Ehrlich ascite carcinoma cells, respectively. Among extracts, DBSB showed highest total capacity reducing ferrous ion. Based 1,1-diphenyl-2-picrylhydrazyl...
The aim of this study was to determine the in-vitro anti-ROS and in-vivo anticancer activities Tabebuia pallida leaves (abbreviated as TPL) against Ehrlich's ascite carcinoma (EAC) cells. crude ethanolic extract (CEE) (70% v/v) fractionated successively with different solvents get petroleum ether (PEF), chloroform (CHF), ethyl acetate (EAF) aqueous fraction (AQF). phytochemical studies were done by standard spectrophotometric methods. cytotoxic activity evaluated brine shrimp nauplii...