A5070619206- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Plant Pathogens and Fungal Diseases
- Antibiotic Use and Resistance
- Streptococcal Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Pneumocystis jirovecii pneumonia detection and treatment
- Neonatal and Maternal Infections
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Intensive Care Unit Cognitive Disorders
- Infections and bacterial resistance
- Head and Neck Surgical Oncology
- Biochemical effects in animals
- Infectious Diseases and Mycology
- Blood transfusion and management
- Infective Endocarditis Diagnosis and Management
- Anesthesia and Neurotoxicity Research
- Antimicrobial Resistance in Staphylococcus
- Bacterial Infections and Vaccines
- Bioactive Compounds and Antitumor Agents
- Burkholderia infections and melioidosis
University Kebangsaan Malaysia Medical Centre
2015-2025
Zhejiang Chinese Medical University
2020-2024
National University of Malaysia
2013-2024
Chaozhou Central Hospital
2024
Wuhan University of Technology
2024
Jinhua Academy of Agricultural Sciences
2023
Shandong First Medical University
2017-2022
Shandong Tumor Hospital
2017-2022
Hospital Kuala Lumpur
2020
KK Women's and Children's Hospital
2015
Isoalantolactone, a sesquiterpene lactone compound possesses antifungal, antibacteria, antihelminthic and antiproliferative activities.In the present study, we found that isoalantolactone inhibits growth induces apoptosis in pancreatic cancer cells.Further mechanistic studies revealed induction of is associated with increased generation reactive oxygen species, cardiolipin oxidation, reduced mitochondrial membrane potential, release cytochrome c cell cycle arrest at S phase.N-Acetyl Cysteine...
Anesthetics are used extensively in surgeries and related procedures to prevent pain. However, there is some concern regarding neuronal degeneration cognitive deficits arising from regular anesthetic exposure. Recent studies have indicated that brain-derived neurotrophic factor (BDNF) cyclic AMP response element-binding protein (CREB) involved learning memory processes. Genistein, a plant-derived isoflavone, has been shown exhibit neuroprotective effects. The present study was performed...
Osteoporosis characterized by decreased bone density and mass, is a systemic disease with the destruction of microstructure increase in fragility. attributed to multiple causes, including aging, inflammation, diabetes mellitus, other factors induced adverse effects medications. Without treatment, osteoporosis will further progress bring great trouble human life. Due various treatment mainly aimed at improving metabolism, inhibiting resorption, promoting formation. Although currently approved...
Bacteremia due to Granulicatella adiacens has been rarely reported in the medical literature. A middleaged gentleman developed necrotizing fasciitis on his left second toe after stepping a nail. ray amputation was performed and ceftazidime-susceptible Pseudomonas aeruginosa isolated from bone culture. However, while receiving ceftazidime for fasciitis, blood culture vial positive gram-positive cocci-shaped bacteria short chains which grew as tiny non-lytic colonies sheep agar only following...
The large-scale application of stainless steel (SS) bipolar plates (BPs) in proton exchange membrane fuel cells (PEMFCs) is mainly limited by insufficient corrosion resistance and electrical conductivity. In this work, Ta-Nb-N coatings were prepared on 316L SS substrates unbalanced magnetron sputtering to improve had a dense structure without obvious defects. simulated PEMFC cathode environments consisting 0.5 M H2SO4 + 2 ppm HF at 70 ± °C, which harsher than the U.S. Department Energy...
Ischemic stroke is the most common type of cerebrovascular disease with high mortality and poor prognosis, cerebral ischemia-reperfusion (CI/R) injury main murderer. Here, we attempted to explore effects mechanism Xuesaitong (XST) combined dexmedetomidine (Dex) on CI/R in rats. First, a rat model was constructed via middle artery occlusion (MCAO) method treated XST Dex alone or combination. Then, 5th 10th days treatment, neurological impairment assessed using modified severity scores (mNSS),...
Cornus officinalis, a medicinal and edible plant known for its liver-nourishing properties, has shown promise in inhibiting the activation of hepatic stellate cells (HSCs), crucial indicators fibrosis, especially when processed by high pressure wine steaming (HPWS). Herein, this study aims to investigate regulatory effects cornus both raw HPWS forms, on inflammation apoptosis liver fibrosis their underlying mechanisms. In vivo models were established subcutaneous injection CCl4, while vitro...
Rhodotorula mucilaginosa fungaemia is rare and highly resistance to antifungal therapy. We herein report a case involving 31-year-old male admitted after high-velocity road traffic accident. He sustained grade IV liver injury with right hepatic vein thrombosis, necessitated an urgent laparotomy. Post-operatively, repeated imaging of the abdomen revealed presence biloma. Percutaneous subdiaphragmatic drainage was done but appeared ineffective, prompting second surgery for hemi-hepatectomy....
Sternal osteomyelitis and mediastinitis are rare yet severe complications post-cardiac surgery, often associated with significant morbidity mortality. Fungal etiologies, particularly those caused by Rhizopus spp., infrequent but can lead to aggressive infections. Here, we present the case of a 68-year-old male who developed sternal spp. two weeks following coronary artery bypass grafting surgery. Debridement pectoralis flap reconstruction were performed clinical identification confirmation...
Vibrio vulnificus is a halophilic gram-negative bacillus that can cause fulminant septicaemia in immunocompromised patients. A 67-year-old man who was immunosuppressed as result of cytotoxic chemotherapy presented with brief history fever, lethargy, myalgia, and reduced oral intake. He had recently travelled to the beach consume seafood. His blood pressure 81/47 mm Hg, necessitating fluid resuscitation followed by inotropic support admission intensive care unit. culture positive for curved...
Cornus officinalis, a kind of edible herbal medicine, has been widely used in the protection liver and kidney due to its medicinal nutritional effect. Its anti-inflammatory, anti-tumor, anti-oxidant activities can be enhanced by wine-steamed (WS) processing. Based on activations hepatic stellate cells-T6 (HSC-T6) HK-2, our study single-factor plus orthogonal design investigate anti-fibrosis C. officinalis processed with steamed (S), high-pressure (HPS), WS, (HPWS), wine-dipped (WD),...
Pancreatic cancer is one of the most malignant tumors that responded poorly to currently available chemotherapy. Casticin, a flavonoid compound, has been reported induce apoptosis in various cell lines. However, there no report on anti-pancreatic potential casticin. In present study, we showed for first time casticin strongly inhibits growth PANC-1 pancreatic carcinoma cells. The anti-proliferative effect assessed by 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay...
Burkholderia pseudomallei is an free-living gram-negative bacterium causing melioidosis and endemic in Southeast Asia. A 56-year-old diabetic construction worker with a 1-month history of abdominal pain 1-day high-grade fever was found to have left non-dissecting infrarenal mycotic aortic aneurysm by computerized tomography scan. Bacteriological examination his blood yielded pseudomallei. The patient treated right axillo-bifemoral bypass excision high-dose intravenous ceftazidime for two...