A5055714054- Radiomics and Machine Learning in Medical Imaging
- Limits and Structures in Graph Theory
- MicroRNA in disease regulation
- Lung Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Advanced Graph Theory Research
- Advanced Topology and Set Theory
- Medical Imaging Techniques and Applications
- Effects of Radiation Exposure
- Cardiac, Anesthesia and Surgical Outcomes
- Endometrial and Cervical Cancer Treatments
- MRI in cancer diagnosis
- Ovarian cancer diagnosis and treatment
- Intensive Care Unit Cognitive Disorders
- Gastric Cancer Management and Outcomes
- Anesthesia and Neurotoxicity Research
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Kruppel-like factors research
- Esophageal Cancer Research and Treatment
- Genomics, phytochemicals, and oxidative stress
- Genetic factors in colorectal cancer
- Cancer, Stress, Anesthesia, and Immune Response
Qingdao University
2015-2025
Affiliated Hospital of Qingdao University
2015-2025
University of Hong Kong
2023-2025
University of Hong Kong - Shenzhen Hospital
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Fudan University
2022-2024
Nanjing Maternity and Child Health Care Hospital
2024
Nanjing Medical University
2024
Miami University
2022-2023
Houston Methodist
2023
Surgery plays an important role in the management of endometrial cancer at all stages, particularly early clinical stage. There are still many unanswered questions regarding optimal surgical cancer, which patients should undergo lymphadenectomy. The aim this study was to evaluate preoperative antigen 125 (CA125) serum levels for patients.A total 995 with according inclusion criteria a level CA125, were selected. association between clinicopathological factors and CA125 analyzed. Receiver...
Anesthetics are used extensively in surgeries and related procedures to prevent pain. However, there is some concern regarding neuronal degeneration cognitive deficits arising from regular anesthetic exposure. Recent studies have indicated that brain-derived neurotrophic factor (BDNF) cyclic AMP response element-binding protein (CREB) involved learning memory processes. Genistein, a plant-derived isoflavone, has been shown exhibit neuroprotective effects. The present study was performed...
Homeobox A3 (HOXA3), one of HOX transcription factors, regulates gene expression during embryonic development. HOXA3 has been reported to be associated with several cancers; however, its role in colon cancer and underlying mechanism are still unclear. The 232 paired human tumor adjacent non-tumorous tissues were measured by qPCR. relationship between clinical outcomes analyzed Kaplan-Meier survival curves analysis. Human cell lines HT29 HTC116 transfected siRNA, or expressing vector, then...
Recent years have seen an increased awareness of sarcopenia in the cross field osteoporosis and sarcopenia. The goal this study was to evaluate current bibliometric characteristics status cross-sectional studies between sarcopenia.Publications related published January 2000 November 2022 were extracted from Web Science Core Collection; visualization performed by Microsoft Office Excel, VOSviewer, Citespace, R.A total 1128 documents written 5791 authors 1758 organizations 62 countries 405...
Introduction: EGFR-sensitive mutations bilateral diffuse lung adenocarcinoma (LUAD) complicated with acute respiratory distress syndrome (ARDS) is relatively rare. It important to consider whether EGFR-TKI can be simultaneously received when treating extracorporeal membrane oxygenation (ECMO) and anti-infective therapy in these patients, what adverse events should noted? Case Presentation: We report a case of EGFR 19 exon-deficient LUAD ARDS. When treated ECMO therapy, the patient oral...
The ARISCAT score, a prospectively developed generic classification for postoperative pulmonary complications (PPCs), has shown excellent predictive performance in general surgery. However, there is no reliable instrument PPCs prediciton thoracic This study aimed to develop and validate novel nomogram estimating the risk of older patients (≥ 65 years) within 30 days after NCTS. A was using predefined candidate predictors 30-day PPCs. It fitted with least absolute shrinkage selection operator...
The aim of this study was to evaluate the predictive value polymorphism Glutathione S-transferase P1 (GSTP1) Ile(105)Val on oxaliplatin/5-FU-based chemotherapy in advanced gastric cancer. Patients with cancer accepted as first-line were investigated. GSTP1 detected by TaqMan-MGB probe allelic discrimination method. Response treatment assessed disease controlled rate. Time progression, overall survival and toxicities recorded. Final patient outcomes follows: allele frequencies...
The rostral ventromedial medulla (RVM) exerts bidirectional descending modulation of pain attributable to the activity electrophysiologically identified pronociceptive ON and antinociceptive OFF neurons. Here, we report that GABAergic neurons specifically express G protein–coupled estrogen receptor (GPER). GPER+ exhibited characteristic ON-like responses upon peripheral nociceptive stimulation. Optogenetic activation facilitated, but their ablation abrogated, pain. Furthermore, GPER caused...
Isoflurane, a widely used anesthetic in surgery, has been found to induce neurotoxicity. In parallel, genistein is thought attenuate isoflurane-induced neurotoxicity, although underlying molecular mechanisms are still unclear. this study, we studied the protective effects of on neuroinflammation rats and BV2 cells.Sprague-Dawley rat pups were exposed 0.75% isoflurane for 6 hours at postnatal day 7 (P7), (20, 40, or 80 mg/kg/day) saline administered from P3 P15. Hippocampal single-cell...
To establish a predictive model incorporating clinical features and contrast enhanced ultrasound liver imaging reporting data system (CEUS LI-RADS) for estimation of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients.
Introduction Postoperative pulmonary complications (PPCs) occur after up to 60% of non-cardiac thoracic surgery (NCTS), especially for multimorbid elderly patients. Nevertheless, current risk prediction models PPCs have major limitations regarding derivation and validation, do not account the specific risks NCTS Well-founded externally validated patients are warranted inform consent treatment decisions. Methods analysis We will develop, internally validate a multivariable model predict...
Understanding the factors that regulate T cell infiltration and functional states in solid tumors is crucial for advancing cancer immunotherapies. Here, we discovered expression of interferon regulatory factor 4 (IRF4) was a critical intrinsic requirement effective anti-tumor immunity. Mice with T-cell-specific ablation IRF4 showed significantly reduced tumor function, resulting accelerated growth subcutaneous syngeneic allowing allogeneic tumors. Additionally, engineered overexpression CD8