A5045119585- Immune Cell Function and Interaction
- Immune cells in cancer
- Sirtuins and Resveratrol in Medicine
- RNA regulation and disease
- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- Cancer-related gene regulation
- Immune Response and Inflammation
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Adenosine and Purinergic Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Autophagy in Disease and Therapy
- Erythrocyte Function and Pathophysiology
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Gut microbiota and health
- Parkinson's Disease Mechanisms and Treatments
- CAR-T cell therapy research
- Reproductive System and Pregnancy
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
Beijing Normal University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Wangjing Hospital of China Academy of Chinese Medical Sciences
2020-2025
Qingdao University
2012-2025
Affiliated Hospital of Qingdao University
2012-2025
Chongqing Medical University
2010-2024
First Affiliated Hospital of Henan University
2018-2024
Beijing Hospital of Traditional Chinese Medicine
2023-2024
Tianjin University
2023-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2010-2024
Significance Macrophages maintain homeostatic proliferation in the presence of mitogens whereas encounters with invading microorganisms inhibit and engage a rapid proinflammatory response. Such cell fate change requires an extensive reprogramming metabolism, regulatory mechanisms behind this remain unknown. We found that myelocytomatosis viral oncogen (Myc) plays major role regulating proliferation-associated metabolic programs. However, stimuli suppress Myc hypoxia-inducible factor alpha...
CD4(+)CD25(+) regulatory T cells (Treg cells) are important in maintenance of peripheral tolerance. The direct effect Treg on macrophages was studied using a mouse model which syngeneic were adoptively transferred into the peritoneal cavity SCID mice. Peritoneal mice with expressed significantly higher levels CD23, CD47 and CD206 less CD80 major histocompatibility complex class II molecules as compared those that received either CD4(+)CD25(-) or no cells. Macrophages injected displayed...
Myeloid-derived suppressor cells (MDSC) display an immature phenotype that may assume a classically activated (M1) or alternatively (M2) in tumors. In this study, we investigated metabolic mechanisms underlying the differentiation of MDSCs into M1 M2 myeloid lineage and their effect on cancer pathophysiology. We found SIRT1 deficiency directs specific switch to when enter periphery from bone marrow, decreasing suppressive function favor proinflammatory associated with tumor cell attack....
Abstract A progressive decline in the integrity of immune system is one physiologic changes during aging. The frequency autoimmune diseases or disorders increases aging population, but state regulatory T (Treg) cells aged individuals has not been well determined. In present study, we investigated levels, phenotypes, and function CD4+CD25+ Treg Balb/c mice, which were older than 20 months. Significantly enhanced percentages periphery (blood, spleen, lymph nodes) mice observed. These showed...
The differentiation of naive CD4(+) T cells into distinct lineages plays critical roles in mediating adaptive immunity or maintaining immune tolerance. In addition to being a first line defense, the innate system also actively instructs through antigen presentation and immunoregulatory cytokine production. Here we found that sirtuin 1 (SIRT1), type III histone deacetylase, an essential role proinflammatory signaling dendritic (DCs), consequentially modulating balance helper (TH1)...
MicroRNAs (miRNA) are involved in and controlled by epigenetic regulation, thereby form a reciprocal regulatory circuit. Using next-generation sequencing (NGS)-based miRNA profiling, this study aimed to discover esophageal squamous cell carcinoma (ESCC)-specific miRNAs miRNA-related modulations.NGS-based profiles were generated for four pairs of ESCC tissues adjacent normal tissues. In situ hybridization was used assess expression its correlation with prognosis. DNA methylations identified...
Malignant tumors develop multiple mechanisms to impair and escape from antitumor immune responses, of which tumor‐associated macrophages that often show immunosuppressive phenotype (M2), play a critical role in tumor‐induced immunosuppression. Therefore, strategies can reverse M2 even enhance immune‐stimulation function macrophage would benefit tumor immunotherapy. In this paper, self‐assembled glyco‐nanoparticles (glyco‐NPs), as artificial glycocalyx, have been found be able successfully...
The management of severe and recalcitrant diabetic foot ulcers is challenging. Distraction osteogenesis accompanied by vascularization regeneration the surrounding tissues. Longitudinal distraction proximal tibia stimulates increased prolonged blood flow to distal tibia. However, effects transverse cortex on are largely unknown.(1) Does tibial increase healing decrease major amputation recurrence compared with routine (which generally included débridement, revascularization, negative...
Dendritic cells (DCs) play an important role in anti-tumor immunity by inducing T cell differentiation. Herein, we found that the DC mechanical sensor Piezo1 stimulated stiffness or inflammatory signals directs reciprocal differentiation of TH1 and regulatory (Treg) cancer. Genetic deletion DCs inhibited generation while driving development Treg promoting cancer growth mice. Mechanistically, Piezo1-deficient regulated secretion polarizing cytokines TGFβ1 IL-12, leading to increased...
Abnormal immunity and its related complications are the major causes of mortality morbidity in diabetes patients. Macrophages, as one important innate cells, play pivotal roles controlling immune homeostasis, immunity, tolerance. The effects hyperglycemia on function macrophages hosts remain to be determined. Here we used mice with streptozotocin (STZ)-induced for long term study changes macrophages. We found that F4/80(+) peritoneal exudate (PEMs) from 4 months displayed significantly...