A5100357116- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Microtubule and mitosis dynamics
- Chromosomal and Genetic Variations
- Animal Genetics and Reproduction
- Signaling Pathways in Disease
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Nutrition and Physiology
- Protein Degradation and Inhibitors
- Peatlands and Wetlands Ecology
- Protein Hydrolysis and Bioactive Peptides
- Rice Cultivation and Yield Improvement
- Mercury impact and mitigation studies
- Fluorine in Organic Chemistry
- Genomics and Chromatin Dynamics
- Peroxisome Proliferator-Activated Receptors
- Photosynthetic Processes and Mechanisms
- Enzyme Structure and Function
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Ion Transport and Channel Regulation
- Toxin Mechanisms and Immunotoxins
- Genetic Mapping and Diversity in Plants and Animals
- Catalysis for Biomass Conversion
- Ubiquitin and proteasome pathways
The University of Texas at Arlington
2024-2025
The University of Texas Southwestern Medical Center
2025
National Medical Products Administration
2023
Xuzhou Medical College
2008-2023
Beijing Academy of Agricultural and Forestry Sciences
2023
Medical University of South Carolina
2023
Ralph H. Johnson VA Medical Center
2023
Chinese Academy of Sciences
2001-2021
Institute of Genetics and Developmental Biology
2014-2021
State Key Laboratory of Plant Genomics
2014-2021
Flowering time (i.e., heading date in crops) is an important ecological trait that determines growing seasons and regional adaptability of plants to specific natural environments. Rice ( Oryza sativa L.) a short-day plant originated the tropics. Increasing evidence suggests northward expansion cultivated rice was accompanied by human selection under noninductive long-day (LD) conditions. We report here molecular cloning characterization DTH2 (for Days on chromosome 2 ), minor-effect...
A large number of hDAF transgenic pigs to be used for xenotransplantation research were generated by using sperm-mediated gene transfer (SMGT). The efficiency transgenesis obtained with SMGT was much greater than any other method. In the experiments reported, up 80% had transgene integrated into genome. Most carrying transcribed it in a stable manner (64%). great majority that expressed protein (83%). transmitted progeny. Expression and found caveolae as is human cells. functional based on...
Abstract A progressive decline in the integrity of immune system is one physiologic changes during aging. The frequency autoimmune diseases or disorders increases aging population, but state regulatory T (Treg) cells aged individuals has not been well determined. In present study, we investigated levels, phenotypes, and function CD4+CD25+ Treg Balb/c mice, which were older than 20 months. Significantly enhanced percentages periphery (blood, spleen, lymph nodes) mice observed. These showed...
Meiotic homologous recombination is pivotal to sexual reproduction. DMC1, a conserved recombinase, involved in directing single-end invasion between interhomologs during meiotic recombination. In this study, we identified OsDMC1A and OsDMC1B, two closely related proteins rice (Oryza sativa) with high sequence similarity DMC1 from other species. Analysis of Osdmc1a Osdmc1b Tos17 insertion mutants indicated that these genes are functionally redundant. Immunolocalization analysis revealed...
Abstract Transgenic animals are produced primarily by microinjecting exogenous DNA into the male pronuclei of a zygote. Microinjection is successful in mice but not efficient farm animals, limiting its general utility. We have pursued an alternative technology for producing transgenic animals: Sperm Mediated Gene Transfer (SMGT). Based on our finding that sperm cells bind and internalize DNA, we used as vector transmitting, only their own also, exogenously‐introduced gene interest to SMGT...
Methane (CH 4 ) fluxes were measured in hypereutrophic Meiliang Bay of Taihu Lake with static chambers for 1 year. The results showed that the macrophyte‐covered infralittoral zones “hotspots” CH emission water systems. There large temporal variations fluxes, ranging from −1.7 to 131 mg m −2 h −1 , littoral zone. highest emissions occurred during period summer algal bloom. amount flux June September accounted about 50–90% annual fluxes. bare zone (−0.2∼4.2 low and close those pelagic...
Significance The programmed double-strand break (DSB) formation is a prerequisite for homologous recombination. synaptonemal complex (SC), known as the meiotic-specific proteinaceous structure, provides an appropriate framework Both are indispensable in meiosis. p31 comet has been proved to play essential role metaphase-to-anaphase transition during mitosis by indirectly activating anaphase-promoting complex/cyclosome status, but underlying function meiosis remains elusive. Here, we...
Abstract Purpose: Glioma-initiating cells (GIC) are glioma stem–like that contribute to glioblastoma (GBM) development, recurrence, and resistance chemotherapy radiotherapy. They have recently become the focus of novel treatment strategies. Cyclophilin A (CypA) is a cytosolic protein belongs peptidyl–prolyl isomerase (PPIase) family major intracellular target immunosuppressive drug cyclosporin (CsA). In this study, we investigate functions CypA its mechanism action in GICs' development....
Huntington's disease (HD) is a lethal autosomal dominant neurodegenerative disorder resulting from CAG repeat expansion in the huntingtin (HTT) gene. The product of translation this gene highly aggregation-prone protein containing polyglutamine tract >35 repeats (mHTT) that has been shown to colocalize with histone deacetylase 4 (HDAC4) cytoplasmic inclusions HD mouse models. Genetic reduction HDAC4 an model resulted delayed aggregation mHTT, along amelioration neurological phenotypes and...
Homologous recombination plays a central role in guaranteeing chromosome segregation during meiosis. The precise regulation of the resolution intermediates is critical for success Many proteins, including RECQ DNA helicases (Sgs1/BLM) and Topoisomerase 3α (TOP3α), have essential functions managing intermediates. However, many other factors involved this process remain to be defined. Here, we report isolation meiotic association 1 (MEICA1), novel protein participating rice (Oryza sativa)....
Abstract MSH4 encodes a MutS protein that plays specialized role in meiosis. In eukaryotic species, such as budding yeast, mice, Caenorhabditis elegans, and Arabidopsis, msh4 mutants display meiotic defects with reduced number of chiasmata. Here, we characterized rice by map-based cloning. Osmsh4 mutants, the chiasma frequency was dramatically decreased to ∼10% wild type, but synaptonemal complex normally installed. The double mutant analysis showed Osmsh5 mutant, reduction chiasmata greater...
RAD51C is one of the RAD51 paralogs that plays an important role in DNA double-strand break repair by homologous recombination. Here, we identified and characterized OsRAD51C, rice homolog human RAD51C. The Osrad51c mutant plant normal vegetative growth but exhibits complete male female sterility. Cytological investigation revealed pairing synapsis were severely disrupted. Massive chromosome fragmentation occurred during metaphase I meiocytes, was fully suppressed CRC1 mutation....
The structure-specific endonuclease ERCC1/XPF plays an important role in nucleotide excision repair and interstrand cross-link repair. In this study, we identified new functions of DNA double-strand break (DSB) We found that the conserved function to remove non-homologous sequences at DSBs is a rate-limiting step for homologous recombination mammalian cells, more importantly, uncovered indispensable containing secondary structures, including structure-prone AT-rich derived from common...
SDS is a meiosis specific cyclin-like protein and required for DMC1 mediated double-strand break (DSB) repairing in Arabidopsis. Here, we found its rice homolog, OsSDS, essential meiotic DSB formation. The Ossds mutant normal vegetative growth but both male female gametes are inviable. meiocytes exhibit severe defects homologous pairing synapsis. No γH2AX immunosignals together with the suppression of chromosome fragmentation Ossds-1 Osrad51c, provide strong evidences that OsSDS...
We present the Generalized Spatial Propagation Network (GSPN), a new attention mechanism optimized for vision tasks that inherently captures 2D spatial structures. Existing models, including transformers, linear attention, and state-space models like Mamba, process multi-dimensional data as 1D sequences, compromising coherence efficiency. GSPN overcomes these limitations by directly operating on spatially coherent image forming dense pairwise connections through line-scan approach. Central...
The ring hydrogenation of benzoic acid to cyclohexanecarboxylic overcharcoal-supported transition metal catalysts in supercritical CO2 medium has been studiedin the present work. can be produced efficiently insupercritical at low reaction temperature 323 K. presence increasesthe rate and several parameters have discussed.
Colistin, a cyclic cationic polypeptide antibiotic that is used to treat infections, may cause neurotoxicity. However, whether colistin can induce apoptosis and the precise mechanism of involved in PC12 cells remains be determined. The aim present study was determine reactive oxygen species (ROS) level DNA damage, as well apoptotic factors such p53, cytochrome c, Bax, Bcl‑2, Fas, Fas‑L caspase family via western blotting treated with sulfate. results showed sulfate increased ROS levels...
Toosendanin (TSN) is an active compound from the fruit of Melia toosendan Sieb et Zucc. TSN has been shown to have broad-spectrum anti-tumour activities in human cancers. However, there are still many gaps knowledge on canine mammary tumours (CMT). CMT-U27 cells were used select optimal acting time and best concentration initiate apoptosis. Cell proliferation, cell colony formation, migration invasion analysed. The expression apoptosis-related genes proteins also detected explore mechanism...
Nerve injury-induced maladaptive changes in gene expression the spinal neurons are essential for neuropathic pain genesis. Circular RNAs (ciRNA) emerging as key regulators of expression. Here, we identified a nervous-system-tissues-specific ciRNA-Kat6 with conservation humans and mice. We aimed to investigate whether how dorsal horn ciRNA-Kat6b participates pain.Unilateral sciatic nerve chronic constrictive injury (CCI) surgery was used prepare model. The differentially expressed ciRNAs were...