A5049124109- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- IL-33, ST2, and ILC Pathways
- Mesenchymal stem cell research
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
- Cancer, Hypoxia, and Metabolism
- Preterm Birth and Chorioamnionitis
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Neonatal Health and Biochemistry
- Asthma and respiratory diseases
- Epigenetics and DNA Methylation
- Respiratory viral infections research
- Angiogenesis and VEGF in Cancer
- Eosinophilic Esophagitis
- Immune Cell Function and Interaction
- Bacteriophages and microbial interactions
- Infant Development and Preterm Care
- Cancer-related gene regulation
- Gut microbiota and health
- Heme Oxygenase-1 and Carbon Monoxide
- Autophagy in Disease and Therapy
Affiliated Hospital of Jiangsu University
2016-2025
Jiangsu University
2016-2025
Beijing Forestry University
2024
Capital Institute of Pediatrics
2024
Shanghai Chest Hospital
2023
Wuhan Polytechnic University
2023
Richard L. Roudebush VA Medical Center
2014-2020
Indiana University – Purdue University Indianapolis
2014-2020
Center for Vascular Biology Research
2016-2020
Nankai University
2012-2019
Rationale: Adipose stromal cells (ASC) are therapeutically potent progenitor that possess properties of pericytes. In vivo, ASC in combination with endothelial (EC) establish functional multilayer vessels, which form the outer vessel layer and differentiate into mural cells. Objective: To identify factors responsible for differentiation toward smooth muscle cell phenotype via interaction EC. Methods Results: An vitro model EC cocultivation was used, organized vascular cords, accompanied by...
It remains a mystery why HIV-associated end-organ pathologies persist in the era of combined antiretroviral therapy (ART). One possible mechanism is continued production HIV-encoded proteins latently HIV-infected T cells and macrophages. The proapoptotic protein HIV-Nef persists blood ART-treated patients within extracellular vesicles (EVs) peripheral mononuclear cells. Here we demonstrate that present EVs isolated from BAL on ART. We hypothesize persistence lung induces endothelial...
The structure-specific endonuclease ERCC1/XPF plays an important role in nucleotide excision repair and interstrand cross-link repair. In this study, we identified new functions of DNA double-strand break (DSB) We found that the conserved function to remove non-homologous sequences at DSBs is a rate-limiting step for homologous recombination mammalian cells, more importantly, uncovered indispensable containing secondary structures, including structure-prone AT-rich derived from common...
Diarrhea is the third leading cause of death in developing countries children under age five. About half a million die diarrhea every year, most which countries. Viruses are main pathogen diarrhea. In China, fecal virome with has been rarely studied. Using an unbiased viral metagenomics approach, we analyzed Many DNA or RNA viruses associated identified those samples were mainly from six families Adenoviridae, Astroviridae, Caliciviridae, Parvoviridae, Picornaviridae, and Reoviridae. Among...
Decreasing oocyte competence with maternal aging is a major factor in mammalian infertility. One of the factors contributing to this infertility changes chromatin modifications, such as histone acetylation old MII stage oocytes. Recent studies indicate that at arise germinal vesicle (GV) stage. We hypothesised methylation could also change GV To test hypothesis, we examined mono-, di- and trimethylation H3 lysine 4 (H3K4 me1, me2 me3, respectively) young older oocytes from 6-8-...
The progressive decline in tissue mechanical strength that occurs with aging is hypothesized to be due a loss of resident stem cell number and function. As such, there concern regarding use autologous adult therapy older patients. To abrogate this, many patients elect cryopreserve the adipose stromal-vascular fraction (SVF) lipoaspirate, which contains cells (ASC). However, it not clear yet if any clinical benefit from banking at younger age. We performed comparative analysis SVF composition...
Introduction Changes in the gut microbiome have been associated with development of acute respiratory infection (ARI). However, due to methodological limitations, our knowledge virome patients ARIs remains limited. Methods In this study, fecal samples from children ARI were investigated using viral metagenomics. Results The was analyzed, and several suspected disease-causing viruses identified. five families highest abundance sequence reads Podoviridae , Virgaviridae Siphoviridae...
The molecular pathomechanisms underlying bronchopulmonary dysplasia (BPD) remain to be fully elucidated, however, lung injury is considered a key event. present study was performed determine the role of endoplasmic reticulum (ER) stress and investigate apoptosis alveolar epithelial cells in BPD rat model. A total 48 preterm Sprague‑Dawley rats were randomly divided into control group hyperoxia group. exposed 85% hyperoxia, while room air. eight each sacrificed 7, 14 or 21 days after...
Abstract Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in preterm infants, characterised by compromised alveolar development and pulmonary vascular abnormalities. Emerging evidence suggests that regulatory T cells (Tregs) may confer protective effects on the vasculature. Knockdown of their transcription factor, interferon factor 4 (IRF4), has been shown to promote endothelial hyperplasia. However, involvement Tregs IRF4 BPD pathogenesis remains unclear. This...
Members of Cytospora include saprobes, endophytes and important plant pathogens, which are widely distributed on various wood hosts have a wide global distribution. In this study, the species definitions were conducted, based multigene phylogeny (ITS, act , rpb2 tef1-α tub2 genes) comparisons morphological characters. A total 22 representative isolates obtained from 21 specimens in Fengtai District Beijing City identified as seven including four known ( C. albodisca ailanthicola euonymina...
Adipose stem/stromal cells (ASCs) after isolation produce numerous angiogenic growth factors. This justifies their use to promote angiogenesis per transplantation. In parallel, local coimplantation of ASC with endothelial (ECs) leading formation functional vessels by the donor suggests existence a mechanism responsible for fine-tuning paracrine activity essential vasculogenesis. As expected, conditioned media (CM) from promoted ECs survival, proliferation, migration, and contrast, EC-ASC...
Acute Respiratory Distress Syndrome (ARDS) is a condition that contributes to morbidity and mortality of critically ill patients. We investigated whether factors secreted by adipose stromal cells (ASC) into conditioned media (ASC-CM) will effectively decrease lung injury in the model lipopolysaccharide (LPS)-induced ARDS.To assess effect ASC-CM on ARDS indices, intravenous delivery ASC C57Bl/6 mice was carried out 4 h after LPS oropharyngeal aspiration; Evans Blue Dye (EBD) injected...
Purpose: The purpose of this study is to investigate the relationship between premature brain injury and multiple biomarkers in cord blood amniotic fluid, identify potential for early monitoring injury.Methods: One hundred thirty cases singleton infants with gestational age less than 34 weeks were evaluated. Based on imaging examination, all divided into group no group. Eleven fluid measured.Results: Levels interleukin-1β (IL-1β), IL-6, IL-8, tumor necrosis factor-α (TNF-α), granulocyte...
Bronchopulmonary dysplasia (BPD) is a common complication in preterm infants characterized by alveolar growth arrest. Interleukin (IL)-33 and type 2 innate lymphoid cell (ILC2) affect II epithelial (AECII) differentiation BPD mice may cause increased lung epithelial-mesenchymal transition (EMT). Amphiregulin (AREG) can be produced ILC2 associated with tissue repair. However, the action mechanism of AREG to development unclear. In this study, we aimed demonstrate role influencing AECII...
Abstract Cigarette smoking (CS) adversely affects the physiologic function of endothelial progenitor, hematopoietic stem and progenitor cells. However, effect CS on ability adipose stem/stromal cells (ASC) to promote vasculogenesis rescue perfusion in context ischemia is unknown. To evaluate this, ASC from nonsmokers (nCS-ASC) smokers (CS-ASC), their activity hindlimb models, as well cell (EC) survival vascular morphogenesis vitro were assessed. While nCS-ASC improved ischemic limbs, CS-ASC...