A5115602146- Immune Cell Function and Interaction
- HIV Research and Treatment
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Immunodeficiency and Autoimmune Disorders
- Reproductive System and Pregnancy
- HIV/AIDS Research and Interventions
- Immune Response and Inflammation
- Hepatitis B Virus Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune responses and vaccinations
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Herpesvirus Infections and Treatments
- Heat shock proteins research
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Cytokine Signaling Pathways and Interactions
- Endometriosis Research and Treatment
- Virology and Viral Diseases
- Cytomegalovirus and herpesvirus research
- Diabetes and associated disorders
- CAR-T cell therapy research
- Phagocytosis and Immune Regulation
Beijing Normal University
2019-2025
Beijing University of Chinese Medicine
2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Wenzhou Medical University
2024
Jinzhou Medical University
2023-2024
Harbin Medical University
2024
Fourth Affiliated Hospital of Harbin Medical University
2024
Weatherford College
2024
Huazhong University of Science and Technology
2024
Tongji Hospital
2024
Dendritic cells (DCs) play an important role in anti-tumor immunity by inducing T cell differentiation. Herein, we found that the DC mechanical sensor Piezo1 stimulated stiffness or inflammatory signals directs reciprocal differentiation of TH1 and regulatory (Treg) cancer. Genetic deletion DCs inhibited generation while driving development Treg promoting cancer growth mice. Mechanistically, Piezo1-deficient regulated secretion polarizing cytokines TGFβ1 IL-12, leading to increased...
Heat shock proteins (HSP) are widely distributed and highly immunogenic molecules. A novel property reported here is that stimulation with HSP70 of CD8-enriched T cells derived from naive non-human primates caused a dose-dependent increase in concentrations the β-chemokines RANTES, macrophage inflammatory protein (MIP)-1α or MIP-1β. However, these were greatly increased when CD8 HSP70-immunized stimulated HSP70. HSP linked to peptides combined generation an adjuvant function by enhancing...
Macrophages differentiated into a classically activated (M1) or alternatively phenotype (M2) in infection and tumor, but the precise effects of glycolysis oxidative phosphorylation (OXPHOS) metabolic pathway remain unclear. Herein, OXPHOS on macrophage polarizations were investigated using pharmacological approach mice. 2-Deoxy-D-glucose (2-DG) treatments, which blocks key enzyme hexokinase glycolysis, efficiently inhibits specific switch to M1 lineage, decreasing secretion pro-inflammatory...
Abstract The metabolism of immune cells reprograms inflammatory responses to protect against infection by pathogenic microorganisms, but the effects glycolysis and oxidative phosphorylation (OXPHOS) metabolic pathway remain unclear. Herein, or OXPHOS on neutrophils T were investigated using a pharmacological approach in mice. 2‐Deoxy‐ d ‐glucose (2‐DG), which blocks key enzyme hexokinase glycolysis, dimethyl malonate (DMM), element succinate OXPHOS, both efficiently expanded population...
Introduction Group 2 innate lymphoid cells (ILC2s) play a crucial role in house dust mite (HDM)-induced allergic inflammation, and allergen immunotherapy (AIT) holds promise for treating the disease by reducing frequency of ILC2s. Despite significant progress AIT diseases, there remains need to improve control symptoms. Methods We investigated synergistic effect Notch signaling pathway subcutaneous (SCIT) airway inflammation mice their impact on ratio ILC2s lung tissues. This was achieved...
One of the obstacles to AIDS vaccine development is variability HIV-1 within individuals and infected populations, enabling viral escape from highly specific induced immune responses. An understanding different mechanisms capable inhibiting HIV infection may be benefit in eventual design vaccines effective against variants. To study this we first compared responses Rhesus monkeys by using two immunization strategies based on same strain HIV-1. We then utilized a chimeric simian/HIV that...
To develop a novel SIV-CCR5 receptor vaccine strategy that will protect macaques from SHIV infection by the vaginal mucosal route.The rationale for this is humans who express homozygous delta32 CCR5 mutation and associated upregulation of CC chemokines, down-modulation cell-surface expression antibodies to are protected against HIV infection.A was prepared consisting three extracellular peptides CCR5, an N-terminal gp120 fragment generated in transgenic plants recombinant SIV p27. These were...
Evidence is presented that the microbial 70-kD heat shock protein (HSP70) binds to CCR5 chemokine receptors in CCR5-transfected cell lines and primary human cells. Significant CCR5-mediated calcium mobilization was stimulated by HSP70 inhibited with TAK 779, which a specific antagonist. HSP70-mediated activation of p38 MAPK phosphorylation signaling pathway also demonstrated HEK 293 Direct binding three extracellular peptides surface plasmon resonance. Functional evidence an interaction...
Abstract Viral immune evasion is crucial to the pathogenesis of hepatitis B virus (HBV) infection. However, role HBV in modulation innate poorly understood. A liver‐specific histone acetyltransferase 1 ( Hat1 ) knockout (KO) mouse model and HAT1 KO cell line were established. Immunohistochemistry staining, Western blot analysis, Southern Northern immunofluorescence assays, enzyme‐linked immunosorbent assay, reverse transcription‐quantitative polymerase chain reaction, chromatin...
Previous xenogeneic immunization experiments in rhesus macaques with simian immunodeficiency virus (SIV) grown human CD4(+) T cells consistently elicited protection from challenge live SIV. However, the mechanism of has not been established. We present evidence that induced significant CD8 suppressor factor, RANTES (regulated upon activation, normal cell expressed and secreted), macrophage inflammatory protein (MIP) 1alpha, MIP-1beta (P < 0.001 - P 0.02). The concentrations these increased...
Successful embryo implantation requires receptive endometrium, which is conducive to the process of recognition, adhesion, and invasion within a certain period time inseparable from dynamic interaction between 17β-estradiol (E2) progesterone (P4). Proper glucose metabolism critical for profound physiological changes in endometrium entering state. And transporters (GLUTs) are responsible intracellular uptake first step metabolism. Prior literature has reported presence GLUTs endometrium....