A5101951814- Plant Molecular Biology Research
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Plant Reproductive Biology
- Circular RNAs in diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Toxic Organic Pollutants Impact
- Plant Stress Responses and Tolerance
- Spine and Intervertebral Disc Pathology
- Atmospheric chemistry and aerosols
- Plant nutrient uptake and metabolism
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Chemokine receptors and signaling
- Cancer Genomics and Diagnostics
- RNA Interference and Gene Delivery
- Mercury impact and mitigation studies
- Plant Virus Research Studies
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Atmospheric Ozone and Climate
- Liver Disease Diagnosis and Treatment
- Photosynthetic Processes and Mechanisms
- Cancer-related gene regulation
Shandong University
2014-2024
Yunnan University
2016-2024
Affiliated Hospital of Qingdao University
2015-2024
Jinshan Hospital of Fudan University
2014-2024
Qingdao University
2015-2024
Second Affiliated Hospital of Nanjing Medical University
2023-2024
Shanghai Children's Medical Center
2024
Beijing Shijitan Hospital
2016-2023
Capital Medical University
2016-2023
Bridge University
2023
Rhizoctonia solani is a major fungal pathogen of rice (Oryza sativa L.) that causes great yield losses in all rice-growing regions the world. Here we report draft genome sequence sheath blight disease pathogen, R. AG1 IA, assembled using next-generation Illumina Genome Analyser sequencing technologies. The encodes large and diverse set secreted proteins, enzymes primary secondary metabolism, carbohydrate-active enzymes, transporters, which probably reflect an exclusive necrotrophic...
Abstract GATA binding protein 3 (GATA3) is a transcriptional activator highly expressed by the luminal epithelial cells in breast. Here we did meta-analysis of available breast cancer cDNA data sets on cohort 305 patients and found that GATA3 was one top genes with low expression invasive carcinomas poor clinical outcome. To validate its prognostic utility, tissue microarray analysis 139 consecutive (n = 417 samples) immunostained monoclonal antibody against GATA3. Low associated higher...
MRI is the gold standard for confirming a pelvic lymph node metastasis diagnosis. Traditionally, medical radiologists have analyzed image features of regional nodes to make diagnostic decisions based on their subjective experience; this diagnosis lacks objectivity and accuracy. This study trained faster region-based convolutional neural network (Faster R-CNN) with 28,080 images metastasis, allowing Faster R-CNN read those diagnoses. For clinical verification, 414 cases rectal cancer at...
The BRI1-EMS suppressor 1 (BES1)/brassinazole-resistant (BZR1) transcription factors, key components in the brassinosteroid signaling pathway, play pivotal roles plant growth and development. However, function of BES1/BZR1 crops during stress response remains poorly understood. In present study, we characterized ZmBES1/BZR1-5 from maize, which was localized to nucleus responsive abscisic acid (ABA), salt drought stresses. Heterologous expression transgenic Arabidopsis resulted decreased ABA...
Abstract The BES1/BZR1 transcription factors regulate the expression of genes responsive to brassinosteroids and play pivotal roles in plant development, but their role regulating kernel development maize remains unclear. In this study, we found that ZmBES1/BZR1-5 positively regulates size. Association analysis candidate 513 diverse inbred lines indicated three SNPs related were significantly associated with width whilst four 100-kernel weight. Overexpression Arabidopsis rice both increased...
Abstract The discovery of molecular markers to detect the precancerous state would have profound implications in prevention breast cancer. We report that expression Polycomb group protein EZH2 increases histologically normal epithelium with higher risk developing identify as a potential marker for detecting preneoplastic lesions vivo and possible target preventative intervention. (Cancer Res 2006; 66(8): 4095-9)
As in mammalian systems, heterotrimeric G proteins, composed of alpha, beta and gamma subunits, are present plants involved the regulation development cell signaling. Besides sole prototypical protein alpha subunit gene, GPA1, Arabidopsis thaliana genome has three extra-large GTP-binding (XLG)-encoding genes: XLG1 (At2g23460), XLG2 (At4g34390) XLG3 (At1g31930). The C-termini XLGs Galpha domains that homologous to whereas their N-termini each contain a cysteine-rich region putative nuclear...
The aim of study was to investigate the anticancer activities Ivermectin (IVM) and possible mechanisms in cells level via cell proliferation inhibition, apoptosis migration inhibition model cancer HeLa.The MTT assay used inhibitory effect IVM on Hela cells, cycle analysed by flow cytometry. neutral comet DNA damage. presence confirmed DAPI nuclear staining Changes mitochondrial membrane potential reactive oxygen species (ROS) levels were determined using Rhodamine 123 DCFH-DA staining....
Artifacts in functional MRI (fMRI) data cause deviations from common distributional assumptions, introduce spatial and temporal outliers, reduce the signal-to-noise ratio of -- all which can have negative consequences for downstream statistical analysis. Scrubbing is a technique excluding fMRI volumes thought to be contaminated by artifacts generally comes two flavors. Motion scrubbing based on subject head motion-derived measures popular but suffers number drawbacks, especially high rates...
ABSTRACT Diabetes mellitus (DM) is an important factor in intervertebral disc degeneration (IDD). Apoptosis of cartilage endplate (CEP) cells one the initiators IDD. However, effects high glucose on CEP are still unknown. Therefore, we conducted present study to evaluate and identify mechanisms those effects. Rat were isolated cultured 10% foetal bovine serum (FBS, normal control) or high‐glucose medium (10% FBS + 0.1 M 0.2 glucose, experimental conditions) for 1 3 days. In addition, treated...
Homeobox A3 (HOXA3), one of HOX transcription factors, regulates gene expression during embryonic development. HOXA3 has been reported to be associated with several cancers; however, its role in colon cancer and underlying mechanism are still unclear. The 232 paired human tumor adjacent non-tumorous tissues were measured by qPCR. relationship between clinical outcomes analyzed Kaplan-Meier survival curves analysis. Human cell lines HT29 HTC116 transfected siRNA, or expressing vector, then...
Abstract Background: Artificial intelligence-assisted image recognition technology is currently able to detect the target area of an and fetch information make classifications according features. This study aimed use deep neural networks for computed tomography (CT) diagnosis perigastric metastatic lymph nodes (PGMLNs) simulate by radiologists, acquire more accurate identification results. Methods: A total 1371 images suspected node metastasis from enhanced abdominal CT scans were identified...
Background: An artificial intelligence system of Faster Region-based Convolutional Neural Network (Faster R-CNN) is newly developed for the diagnosis metastatic lymph node (LN) in rectal cancer patients. The primary objective this study was to comprehensively verify its accuracy clinical use. Methods: Four hundred fourteen patients with discharged between January 2013 and March 2015 were collected from 6 centers, magnetic resonance imaging data pelvic LNs each patient identified by R-CNN....
Superhydrophobic coatings are gaining importance not only in military technology, industrial engineering, power systems and transportation, but also food science biomedicine, where they have enormous potential for real-time applications. Many research institutes recently been working on the development of superhydrophobic blood-repellent tubes to replace clinical heparin-coated during ECMO therapy, biological toxicity high blood adhesion significantly hampered their practical In this study,...