A5102149060- Lipid Membrane Structure and Behavior
- Air Quality and Health Impacts
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Graphene and Nanomaterials Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Carbon and Quantum Dots Applications
- MicroRNA in disease regulation
- Computer Graphics and Visualization Techniques
- HVDC Systems and Fault Protection
- Nanoparticles: synthesis and applications
- Genetics and Neurodevelopmental Disorders
- 3D Shape Modeling and Analysis
- Reproductive Biology and Fertility
- Anesthesia and Neurotoxicity Research
- Coastal and Marine Dynamics
- Fluid Dynamics Simulations and Interactions
- Nanocluster Synthesis and Applications
- Neurogenesis and neuroplasticity mechanisms
- Maritime Navigation and Safety
- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
Qingdao University
2019-2025
Virginia Tech
2019-2025
Zhejiang Ocean University
2021-2024
Zhejiang University
2021-2024
Virginia–Maryland College of Veterinary Medicine
2019-2024
Tianjin University
2024
Poultry Research Institute
2020-2023
Shandong University
2015-2022
National University of Defense Technology
2021-2022
University of Toronto
2022
Abstract Life experience can leave lasting marks, such as epigenetic changes, in the brain. How life is translated into storable information remains largely unknown. With unbiased data-driven approaches, we predicted that Egr1 , a transcription factor important for memory formation, plays an essential role brain programming. We performed EGR1 ChIP-seq and validated thousands of binding sites with methylation patterns established during postnatal development. More specifically, these become...
While originally identified as an antiviral pathway, recent work has implicated cyclic GMP-AMP-synthase-Stimulator of Interferon Genes (cGAS-STING) signaling playing a critical role in the neuroinflammatory response to traumatic brain injury (TBI). STING activation results robust inflammatory characterized by production cytokines called interferons, well hundreds interferon stimulated genes (ISGs). Global knockout (KO) mice inhibiting this pathway display neuroprotection with evidence that...
The exposure of MoS2 nanosheets can cause cytotoxicity, which causes health risks and affects its medical applications. However, knowledge the underlying molecular mechanisms remains limited. This study reports that induces ferroptosis in vivo vitro, is caused by nanosheet themselves rather than dissolved ions. induce epithelial (BEAS-2B) macrophage (RAW264.7) cells due to nuclear receptor coactivator 4 (NCOA4)-dependent excusive ferritinophagy inhibition ferroportin-1 (FPN). In this...
Abstract Monocytes represent key cellular elements that contribute to the neurological sequela following brain injury. The current study reveals trauma induces augmented release of a transcriptionally distinct CD115 + /Ly6C hi monocyte population into circulation mice pre-exposed clodronate depletion conditions. This phenomenon correlates with tissue protection, blood–brain barrier stability, and cerebral blood flow improvement. Uniquely, this shifted innate immune cell profile in cortical...
Halogenated organic compounds (HOCs) are a class of contaminants showing high toxicity, low biodegradability, and bioaccumulation potential, especially chlorinated brominated HOCs (Cl/Br-HOCs). Knowledge gaps exist on whether novel Cl/Br-HOCs could penetrate the placental barrier cause adverse birth outcomes. Herein, 326 cord blood samples were collected in hospital Jinan, Shandong Province from February 2017 to January 2022, 44 identified with communicating confidence level above 4 based...
Pharmaceuticals and their transformation products (TPs) in wastewater are emerging contaminants that pose risks to ecosystems human health. Here, a typical period marked by the easing of "zero-COVID" policy December 2022, resulting unprecedented infections China, was chosen illustrate environmental impact pharmaceutical usage during COVID-19 pandemic. A suspect screening workflow developed identify pharmaceuticals influent effluent from treatment plant (WWTP) peak postpeak periods COVID-19,...
ABSTRACT Astrocytes are the most abundant glial cell type in central nervous system (CNS). born during early postnatal period rodent brain and mature alongside neurons, demonstrating remarkable morphological structural complexity, which is attained second month. Throughout this of development across remainder lifespan, astrocytes participate CNS homeostasis, support neuronal partners, contribute to nearly all aspects function. In present study, we analyzed astrocyte gene expression cortex...
Herein, we demonstrate a new class of core–shell magnetic carbon hybrid materials (Fe3O4@C) for remarkable adsorptive desulfurization dibenzothiophene (DBT), which have been successfully prepared through hydrocarbonization glucose on the surface Fe3O4 and subsequent pyrolyzation process. The as-obtained Fe3O4@C retains amorphous nature shells with large area displays an increase iron atoms as active sites under elevated temperature is favorable in adsorption sulfur-containing species...
The genetic improvement of economic traits suggests that chicken is an excellent model for exploring the changes and molecular mechanisms underlying phenotypic diversity artificial selection. Here, sequencing data including 477 samples from 25 breeds worldwide were used to reveal genomic patterns domestication. We analyzed 7.4 Tb clean with 14.8× per individual identify 23,504,766 SNPs, 3,289,782 InDels, 27,027 SVs. analysis indicates high-intensity selection would accelerate population...
Background: Traumatic brain injury (TBI) remains a significant risk factor for post-traumatic epilepsy (PTE). The pathophysiological mechanisms underlying the injury-induced epileptogenesis are under investigation. dentate gyrus—a structure that is highly susceptible to injury—has been implicated in evolution of seizure development. Methods: Utilizing murine unilateral focal control cortical impact (CCI) injury, we evaluated onset using 24/7 EEG video analysis at 2–4 months post-injury....
Traumatic brain injury (TBI) can lead to post-traumatic epilepsy (PTE). Blast TBI (bTBI) found in Veterans presents with several complications, including cognitive and behavioral disturbances PTE; however, the underlying mechanisms that drive long-term sequelae are not well understood. Using an unbiased proteomics approach a mouse model of repeated bTBI (rbTBI), this study addresses gap knowledge. After rbTBI, mice were monitored using continuous, uninterrupted video-EEG for up four months....
SUMMARY The DNA modifications, 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), represent powerful epigenetic regulators of temporal spatial gene expression. Yet, how the cooperation these genome-wide, marks determine unique transcriptional signatures across different brain cell populations is unclear. Here we applied Nanopore sequencing native to obtain a complete, single-base resolution atlas 5mC 5hmC modifications in neurons, astrocytes microglia mouse cortex (99% genome...