Metabolic associated fatty liver disease (MAFLD), previously defined as non-alcoholic (NAFLD), has been shown to be closely related many environmental pollutants. Lately, we found methyl tert-butyl ether (MTBE), a new pollutant, could increase NAFLD risk in American adults, which still needs more population epidemiological studies verify, and its pathogenic mechanism is not yet clear. We conducted cross-sectional study among petrol station workers, diagnosed their MAFLD according...

Abstract The regulatory roles of Th1 and Th2 cells in immune protection against Helicobacter infection are not clearly understood. In this study, we report that a primary H. pylori can be established the absence IL-12 or IFN-γ. However, IFN-γ, but IL-12, was involved development gastritis because IFN-γ−/− (GKO) mice exhibited significantly less inflammation as compared with IL-12−/− wild-type (WT) mice. Both GKO failed to develop following oral immunization lysate cholera toxin adjuvant. By...

Abstract Diabetes-associated cognitive impairment (DACI) can increase the risk of major cardiovascular events and death. Neuronal functionality is highly dependent on mitochondria emerging evidence has shown that mitochondrial transplantation a potential effective strategy reduce brain injury associated disorders. Platelets are abundant in blood be considered readily available source small-size mitochondria. These cells easily acquired from peripheral with minimal invasion via simple...

Aims: Iron metabolism is involved in many biological processes the brain. Alterations iron homeostasis have been associated with several neurodegenerative disorders. Instead of stroke and ischemic heart disease, dementia has become second leading cause mortality among type 2 diabetes mellitus (T2DM) population. Therefore, we attempted to investigate role ferroptosis diabetes-associated cognitive dysfunction (DACD). Results: We evaluated hallmarks hippocampus T2DM (high-fat...

Sepsis-associated encephalopathy (SAE) often manifests in severe diffuse cerebral dysfunction due to an aberrant systemic immune response infection. The underlying pathophysiology of SAE is not entirely understood but likely a multifactorial process that involves disruption cell death mechanism. Ferroptosis novel form programmed characterized by iron accumulation and lipid peroxidation, leading inflammatory cascade glutamate release. We hypothesized ferroptosis involved the...

Intestinal barrier dysfunction is associated with the occurrence and development of sepsis. Further, aerobic glycolysis plays an essential role in inflammation cell death. This study aimed at investigating protective effect mechanism PFKFB3 inhibition on intestinal sepsis mice. Sepsis mouse models were established by cecal ligation puncture (CLP) wild-type mice Gsdmd-/- The results showed that expression 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) small intestines was...

Recent studies have revealed that circular RNAs (circRNAs) play important roles in the tumorigenesis of human cancer, including hepatocellular carcinoma (HCC). In present study, we screen RNA expression profiles HCC tissue and investigate molecular on tumorigenesis. Human circRNA microarray analysis showed there were total 1,245 differently expressed RNAs, 756 up-regulated circRNAs 489 down-regulated circRNAs, three pairs adjacent normal tissue. Hsa_circ_0016788 was identified to be both...

Acute lung injury (ALI) has been known to be a devastating form of respiratory infection and an important contributor mortality in intensive care, due its lacking effective treatment. Inflammation, oxidative stress, pyroptosis are associated with multiple kinds inflammatory diseases such as ALI. It is commonly accepted that Gly-Pro-Ala (GPA) peptide regulates stress different diseases. Our study aimed at exploring the regulatory function protective effects GPA peptides on In current study,...

Roughly one third of non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)-sensitive mutated (EGFRm) tumors experience disease progression through central nervous system (CNS) metastases during treatment. Although EGFR-TKIs have been reported to be favored in some EGFRm NSCLC CNS metastases, novel proven efficacy pathologies are clinically needed.To investigate whether almonertinib, a third-generation EGFR-TKI for NSCLC, can...

This study aims to investigate the early changes in immune systems of patients with septic shock. A total 243 shock were included this study. The classified as survivors (n = 101) or nonsurvivors 142). Clinical laboratories perform tests system’s function. Each indicator was studied alongside healthy controls 20) same age and gender patients. comparative analysis every two groups conducted. Univariate multivariate logistic regression analyses performed identify mortality risk factors that...

Nerve conduit is one of strategies for spine cord injury (SCI) treatment. Recently, studies showed that biomaterials could guide the neurite growth and promote axon regeneration at site. However, scaffold by itself was difficult to meet need SCI functional recovery. The basic fibroblast factor (bFGF) administration significantly promotes recovery after organ injuries. Here, using a rat model T9 hemisected SCI, we aimed assessing repair capacity implantation collagen (CS) modified binding...

One-lung ventilation (OLV) can result in local and systemic inflammation. This prospective, randomized trial was to evaluate the effect of therapeutic hypercapnia on lung injury after OLV.Fifty patients aged 20 60 yr undergoing lobectomy were randomly provided with air or carbon dioxide (partial pressure dioxide: 35 45 mmHg 70 mmHg). Peak pressure, plateau compliance recorded. Bronchoalveolar lavage fluid (BALF) blood samples collected. Adverse events monitored. The primary outcome...

Pyroptosis plays a pivotal role in sepsis and septic shock animal studies. However, its clinical significance pathological conditions has not been well elucidated. This study aimed to evaluate the correlation between percentage of pyroptotic peripheral blood mononuclear cells (PBMCs) index investigate relationship PBMCs pyroptosis development trauma patients. prospective was conducted from October 2016 May 2017 comprehensive center. Sixty patients 10 healthy controls were enrolled....

Mesenchymal stem cells (MSCs) are characterized by multidifferentiation and immunoregulatory potential have been used in the treatment of spinal cord injury (SCI), but direct transplantation may limit effectiveness due to their quick diffusion. The role macrophages healing is being increasingly recognized because ability polarize into pro- anti-inflammatory phenotypes. In present study, nerve-guide collagen scaffold (CS) combined with rat MSCs was developed. After CS confirmed minimize MSC...

Cell dysfunction and death induced by lung ischaemia-reperfusion injury (LIRI) are the main causes of in transplant patients. Activation cGAS-STING-induced immune response plays a critical role multiple organ injuries. However, no study has yet investigated cGAS-STING pathway LIRI after transplantation. Sprague-Dawley (SD) rats were subjected to left transplantation administered inhibitors cGAS STING. The expression cGAS-STING-TBK1-IRF3, histological injury, pulmonary permeability, levels...

Mitochondrial dysfunction and neuronal impairment are hallmark features of Diabetes-Associated Cognitive Dysfunction (DACD), mitochondrial transplantation is also a therapeutic intervention for DACD. However, the precise mechanism underlying its effects not fully elucidated. Given that imbalances in copper homeostasis cuproptosis associated with various neurodegenerative disorders diabetic myocardial damage, we hypothesize role pathogenesis We further propose peripheral may ameliorate DACD...