A5042850922- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Aluminum toxicity and tolerance in plants and animals
- Heavy Metal Exposure and Toxicity
- Occupational and environmental lung diseases
- Heat shock proteins research
- Trace Elements in Health
- TGF-β signaling in diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Toxic Organic Pollutants Impact
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- RNA modifications and cancer
- Selenium in Biological Systems
- Effects and risks of endocrine disrupting chemicals
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Anesthesia and Neurotoxicity Research
- Alzheimer's disease research and treatments
- Allergic Rhinitis and Sensitization
- Indoor Air Quality and Microbial Exposure
- Adipokines, Inflammation, and Metabolic Diseases
- Glutathione Transferases and Polymorphisms
Capital Medical University
2016-2025
Capital University
2017-2024
In-Q-Tel
2015-2017
Beijing Administration Institute
2015-2017
Faculty of Public Health
2015
Huazhong University of Science and Technology
2005-2013
Huazhong Agricultural University
2010
Shanxi Medical University
2005-2007
Lawson Health Research Institute
2002
Abstract: Despite the widespread application of silica nanoparticles (SiNPs) in industrial, commercial, and biomedical fields, their response to human cells has not been fully elucidated. Overall, little is known about toxicological effects SiNPs on cardiovascular system. In this study, with a 58 nm diameter were used study interaction umbilical vein endothelial (HUVECs). Dose- time-dependent decrease cell viability damage plasma-membrane integrity showed cytotoxic potential SiNPs. found...
Pneumoconiosis refers to a class of serious diseases threatening the health workers exposed coal or silicosis dust. However, burden pneumoconiosis is unavailable in China.Incident cases, deaths, and disability-adjusted life years (DALYs) from its subtypes China were estimated Global Burden Disease Study 2019 using Bayesian meta-regression method. The trend was analyzed percentage change annualized rate (ARC) during period 1990-2019. relationship between subnational socio-demographic index...
Metabolic associated fatty liver disease (MAFLD), previously defined as non-alcoholic (NAFLD), has been shown to be closely related many environmental pollutants. Lately, we found methyl tert-butyl ether (MTBE), a new pollutant, could increase NAFLD risk in American adults, which still needs more population epidemiological studies verify, and its pathogenic mechanism is not yet clear. We conducted cross-sectional study among petrol station workers, diagnosed their MAFLD according...
Polybrominated diphenyl ethers (PBDEs), which are persistent organic pollutants, affect thyroid function. Human exposure to decabromodiphenyl ethane (DBDPE), has a similar structure PBDEs, recently increased, and the health effects of DBDPE have not been well studied. The objective this study was determine whether human associated with hormone levels in adults from manufacturing area. Three hundred-two blood samples were collected two populations largest area located North China: 133...
Abstract Background The biosafety concern of silica nanoparticles (SiNPs) is rapidly expanding alongside with its mass production and extensive applications. cardiovascular effects SiNPs exposure have been gradually confirmed, however, the interaction between atherosclerosis, underlying mechanisms still remain unknown. Thereby, this study aimed to explore on progression investigate related mechanisms. Results We firstly investigated in vivo atherosclerosis via intratracheal instillation ApoE...
Manganese (Mn) accumulates in the central nervous system and can cause neurotoxicity, but mechanisms of Mn-induced neurotoxicity remain unclear. We performed single-cell RNA sequencing (scRNA-seq) zebrafish brain after Mn exposure identified 10 cell types by marker genes: cholinergic neurons, dopaminergic (DA) glutaminergic GABAergic neuronal precursors, other microglia, oligodendrocyte, radial glia, undefined cells. Each type has its distinct transcriptome profile. Pseudotime analysis...
Abstract Background Over exposure to manganese (Mn) can damage the human central nervous system and potentially cause liver toxicity. Alcohol drinking is also one of well-known harmful factors hepatic organism. The interaction between Mn alcohol consumption function was investigated in this study. Methods A total 1112 on-the-spot workers were included cross-sectional survey from a large scale exposed healthy cohort (MEWHC) ferro-manganese refinery company. questionnaire used collect...
The cytokinin, 6-benzylaminopurine, is converted to its 7-glucoside in intact seedlings, organ slices, and tissue cultures from several plants. ribonucleoside 5′-ribonucleotide appear transiently, the general metabolic sequence seems be nearly identical four plant species thus far studied. glucoside persists for long periods tissues, while all other forms of cytokinin are rapidly metabolized disappear within a few hours. A procedure isolation pure form described.
Drinking water fluoridation was a mid-twentieth century innovation based on the medical hypothesis that consuming low doses of fluoride at teeth forming years provided protection against dental decays. Numerous studies showed high level exposure to could cause and skeleton fluorosis. However, there limited study focusing fluorosis effect levels fluoride. Therefore, our aimed examine whether (measured in blood plasma household tap water) associated with risk data National Health Nutrition...
A method has been developed and validated for the concurrent extraction, clean‐up, analysis of polybrominated diphenyl ethers ( PBDE s), α‐, β‐, γ‐hexabromocyclododecane HBCD ), tetrabromobisphenol (TBBPA) in human milk serum. Milk serum samples were extracted using accelerated solvent extraction with acetone/hexane 1:1, v/v liquid–liquid methyl ‐tert ‐butyl ether/hexane v/v, respectively. The removal co‐extracted biogenic materials was achieved by gel permeation chromatography followed...
Abstract Aim Periodontitis is one of the most common oral diseases and a major cause tooth loss in adults. Environmental pollution closely associated with prevalence periodontitis. However, few studies have focused on association between volatile organic compounds (VOCs) This cross‐sectional study aims to examine whether exposure VOCs periodontitis, based data from National Health Nutrition Examination Survey (NHANES, 2011–2014). Materials Methods We analysed blood VOC levels, periodontitis...
Epidemiological studies have shown that air pollution particulate matter (PM) is associated with increased respiratory morbidity and mortality. However, the mechanisms are not fully understood. Oxidative stress-mediated apoptosis plays an important role in occurrence of diseases. In this study, human bronchial epithelial (16-HBE) cells were exposed to different concentrations (16–128 µg/ml) PM2.5 for 24 h investigate induced by PM2.5. The results showed exposure significantly apoptosis, DNA...