A5101532932- Neuroblastoma Research and Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Selenium in Biological Systems
- RNA Research and Splicing
- Carcinogens and Genotoxicity Assessment
- Pluripotent Stem Cells Research
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Peroxisome Proliferator-Activated Receptors
- Pancreatic and Hepatic Oncology Research
- Bioinformatics and Genomic Networks
- Cancer Genomics and Diagnostics
- CRISPR and Genetic Engineering
- Innovation Diffusion and Forecasting
- Ferroptosis and cancer prognosis
- Energy, Environment, Economic Growth
- Cancer, Hypoxia, and Metabolism
- Cardiac Ischemia and Reperfusion
- Metabolism, Diabetes, and Cancer
- Air Quality and Health Impacts
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Boron Compounds in Chemistry
- Plant Toxicity and Pharmacological Properties
Central South University
2023-2024
Second Military Medical University
2024
Shanghai Jiao Tong University
2012-2023
University of Macau
2023
Shanghai First Maternity and Infant Hospital
2017-2023
Chinese PLA General Hospital
2023
Southeast University
2022-2023
Fujian Agriculture and Forestry University
2019-2022
Zhongshan Hospital
2018-2021
Fudan University
2018-2021
The four major RNA adenosine modifications, i.e., m
Large language models (LLMs) such as OpenAI's o1 have demonstrated remarkable abilities in complex reasoning tasks by scaling test-time compute and exhibiting human-like deep thinking. However, we identify a phenomenon term underthinking, where o1-like LLMs frequently switch between different thoughts without sufficiently exploring promising paths to reach correct solution. This behavior leads inadequate depth of decreased performance, particularly on challenging mathematical problems. To...
Polybrominated diphenyl ethers (PBDEs), which are persistent organic pollutants, affect thyroid function. Human exposure to decabromodiphenyl ethane (DBDPE), has a similar structure PBDEs, recently increased, and the health effects of DBDPE have not been well studied. The objective this study was determine whether human associated with hormone levels in adults from manufacturing area. Three hundred-two blood samples were collected two populations largest area located North China: 133...
Unlike other epithelial cancer types, circulating tumor cells (CTCs) are less frequently detected in the peripheral blood of non-small cell lung (NSCLC) patients using marker-based detection approaches despite aggressive nature NSCLC. Here, we demonstrate hexokinase-2 (HK2) as a metabolic function-associated marker for CTCs. In 59 NSCLC bearing cytokeratin-positive (CKpos) primary tumors, HK2 enables resolving cytokeratin-negative (HK2high/CKneg) CTCs prevalent population about half samples...
Abstract Accurate prediction of chemo- or targeted therapy responses for patients with similar driver oncogenes through a simple and least-invasive assay represents an unmet need in the clinical diagnosis non-small cell lung cancer. Using single-cell on-chip metabolic cytometry fluorescent probes, we show phenotyping on rare disseminated tumor cells pleural effusions across panel 32 adenocarcinoma patients. Our results reveal extensive heterogeneity that differentially engage glycolysis...
Digitization has been the new engine for high-quality economic development. This paper explores how digitization affects enterprises' green technology innovation. The study finds that a positive effect on mediating suggests can promote innovation by optimizing structure of human capital, increasing attention media and easing financing constraints. heterogeneity test larger enterprise scale, higher quality internal control, stronger promotion digitalization to innovation; greater degree...
A small subgroup of embryonic stem cells (ESCs) exhibit molecular features similar to those two-cell embryos (2C). However, it remains elusive whether 2C-like and 2C share epigenetic features. Here, we map the genome-wide profiles histone H3K4me3 H3K27me3 in cells. We found that majority genes inherit their status from ESCs. Among showing a switch methylation during transitions, only number acquire 2C-embryo signatures. In contrast, broad domains display extensive loss Most differentially...
Cardiovascular disease, which is mainly caused by coronary atherosclerosis, one of the leading causes death and disability worldwide. Gut microbiota likely play an important role in atherosclerosis. This study aims to investigate profile adults with atherosclerosis provide a theoretical basis for future research.Fecal samples were collected from 35 adult patients diagnosed 32 healthy Nanjing, China, V3-V4 region 16S rDNA genes was sequenced using high-throughput sequencing. Differences alpha...
There are some researches about the role of microRNA (miRNA) in chronic heart failure (CHF) were performed, but study miR-93's function CHF is scarcely investigated. Thus, we determined to probe into effects miR-93 rats with by targeting LIMK1 through regulating RhoA/ROCK pathway.We found increased and decreased rats, up-regulation inhibited LIMK1, RhoA ROCK1 expression rats. Up-regulation or inhibition oxidative stress, inflammatory factors, as well apoptosis-related indicators was...
There is no approved targeted therapy for chordoma at present. Although several preclinical studies have implied the potential applicability of CDK4/6 inhibitor this rare tumor, clinical evidence has been documented so far. The purpose study was to elucidate therapeutic efficacy chordoma.
Abstract Objectives The study aimed to examine the anti-diabetic effects of Gynura divaricata (GD) and underlying mechanism. Methods Information about chemical compositions GD was obtained from extensive literature reports. Potential target genes were predicted using PharmMapper analyzed Kyoto Encyclopedia Genes Genomes (KEGG) Gene Ontology (GO). To validate results bioinformatics analyses, an aqueous extract administered type 2 diabetic rats established by feeding a high-fat high-sugar diet...
Colitis-associated colorectal cancer (CAC) is a specific type of (CRC) with high mortality and morbidity, the chronic inflammation in intestinal mucosal characteristic CAC. Chang Qing formula (CQF) Chinese herbal used clinically for treatment CAC remarkable clinical efficacy, but its mechanism remains unclear. In present work, Combined network pharmacology transcriptomics were to analyze potential active ingredients elucidate molecular CQF treating Firstly, constituents migrating blood...
Lupus nephritis (LN) is one of the most serious complications systemic lupus erythematosus (SLE) and leading causes death. An alternative effective treatment to ameliorate relieve LN delay process renal tissue fibrosis urgently needed in clinical setting. Jieduquyuziyin prescription (JP) has been successfully used treat SLE, but its potential mechanisms are not sufficiently understood. In this study, we treated MRL/lpr mice with JP for 8 weeks human tubular epithelial cells (human kidney 2...
The METTL3-METTL14 complex, the "writer" of N6-methyladenosine (m6A), plays an important role in many biological processes. Previous studies have shown that Mettl3 overexpression can increase level m6A and promote somatic cell reprogramming. Here, we demonstrate Mettl14, another component methyltransferase significantly enhance generation induced pluripotent stem cells (iPSCs) m6A-independent manner. In cooperation with Oct4, Sox2, Klf4, c-Myc, overexpressed Mettl14 transiently promoted...
BACKGROUND:Cardiac infarction frequently leads to arrhythmia and ischemia/reperfusion (I/R) aggravates cardiac injury. Pinocembrin can resist cerebral ischemia decrease area. This study thus generated a rat myocardial I/R model assess the effect on ventricular rhythm expression of gap junction connexin (Cx43). MATERIAL AND METHODS:Male SD rats were randomly assigned into sham, model, pinocembrin (30 mg/kg) pretreatment groups (N=15 each). The was by ligation left anterior descending coronary...
Breast cancer is the most common in women, but few biomarkers are effective clinic. Previous studies showed important roles of non-coding RNAs diagnosis, prognosis and therapy selection breast cancer, suggested significance integrating molecules at different levels for interpreting mechanism cancer. Here we collected transcriptome data including long RNA (lncRNA), microRNA (miRNA) mRNA ~1,200 samples 1079 invasive carcinoma samples, as well 104 normal from The Cancer Genome Atlas (TCGA)...
Mammalian oocytes possess fascinating unknown factors, which can reprogram terminally differentiated germ cells or somatic into totipotent embryos. Here, we demonstrate that oocyte-specific homeobox 1 (Obox1), an factor, markedly enhance the generation of induced pluripotent stem (iPSCs) from mouse fibroblasts in a proliferation-independent manner and replace Sox2 to achieve pluripotency. Overexpression Obox1 greatly promote mesenchymal-to-epithelial transition (MET) at early stage...
Multiple chromatin modifiers associated with H3K9me3 play important roles in the transition from embryonic stem cells to 2-cell (2C)-like cells. However, it remains elusive how is remodeled and its association totipotency. Here, we integrated transcriptome profiles conduct a detailed comparison of 2C embryos 2C-like Globally, highly preserved dynamics within gene locus not expression change during transition. Promoter-deposited plays non-repressive activation genes In contrast, transposable...
Background: Pyroptosis is a recently identified mode of programmed inflammatory cell death that has remarkable implications for cancer development. lncRNAs can be involved in cellular regulation through various pathways and play critical role gastric (GC). However, pyroptosis -related (PRlncRNAs) have been rarely studied GC. Methods: Pyroptosis-related gene were abstracted from the literature GSEA Molecular Signatures data resource. PRlncRNAs obtained using co-expression analysis. LASSO Cox...