A5074899069- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Animal Genetics and Reproduction
- Reproductive Biology and Fertility
- Pluripotent Stem Cells Research
- Reproductive System and Pregnancy
- Chalcogenide Semiconductor Thin Films
- CRISPR and Genetic Engineering
- Chromosomal and Genetic Variations
- Blood Pressure and Hypertension Studies
- Gas Sensing Nanomaterials and Sensors
- Renal and related cancers
- Peripheral Artery Disease Management
- Ion Channels and Receptors
- Cellular Mechanics and Interactions
- Nanoparticles: synthesis and applications
- Endometriosis Research and Treatment
- Mineralogy and Gemology Studies
- Healthcare professionals’ stress and burnout
- Cardiac Ischemia and Reperfusion
- Crystal Structures and Properties
- Advanced Nanomaterials in Catalysis
Fuwai Yunnan Cardiovascular Hospital
2022-2024
Kunming Medical University
2022-2024
Shanghai First Maternity and Infant Hospital
2021-2024
Jinan University
2022-2023
Shanghai East Hospital
2022
Tongji University
2022
Shangrao Normal University
2022
SAIC-GM (China)
2021
Zhejiang Provincial People's Hospital
2020
Chinese Academy of Sciences
2017-2019
Major evolutionary transitions are enigmas, and the most notable enigma is between invertebrates vertebrates, with numerous spectacular innovations. To search for molecular connections involved, we asked whether global epigenetic changes may offer a clue by surveying inheritance reprogramming of parental DNA methylation across metazoans. We focused on gametes early embryos, where methylomes known to evolve divergently fish mammals. Here, find that methylome during embryogenesis occurs...
Adenomyosis is a poorly understood gynecological disorder lacking effective treatments. Controversy persists regarding "invagination" and "metaplasia" theories. The endometrial-myometrial junction (EMJ) connects the endometrium myometrium important for diagnosing classifying adenomyosis, but its in-depth study just beginning. Using single-cell RNA sequencing spatial profiling, we mapped transcriptional alterations across eutopic endometrium, lesions, EMJ. Within identified unique epithelial...
DNA methylation plays important roles during development. However, the reprogramming of functional elements has not been fully investigated mammalian embryonic Herein, using our modified MethylC-Seq library generation method and published post-bisulphite adapter-tagging (PBAT) method, we generated genome-wide methylomes human gametes early embryos at single-base resolution compared them with mouse methylomes. We showed that dynamics in are conserved between humans mice embryogenesis, except...
Alhagi maurorum (camelthorn) is one of the popular medicinal plants. The plant has many pharmaceutical uses in traditional medicine. In this study, nickel nanoparticles were synthesized according to green chemistry rules using aqueous extract A. maurorum. green-synthesized NiNPs characterized different techniques such as EDX, FE-SEM, XRD, UV–vis and FT-IR. FE-SEM results confirm spherical morphology for with size 20.56–36.63 nm. oncological part present treated cells assessed by MTT assay 48...
Multicellular organisms require precise gene regulation during ontogeny, and epigenetic modifications, such as DNA methylation histone modification, facilitate this regulation. The conservative reprogramming patterns of in vertebrates have been well described. However, knowledge how modifications are passed on from gametes to early embryos is limited, whether modification conserved not clear. We profiled H3K4me3/H3K27me3 zebrafish found that the promoter regions largely set either...
Morphology-control, as a promising and effective strategy, is widely implemented to change surface atomic active sites thus enhance the intrinsic electrocatalytic activity selectivity. As typical n-type semiconductor, series of bismuth vanadate samples with tunable morphologies clavate, fusiform, flowered, bulky, nanoparticles were prepared investigate morphology effect. Among all synthesized samples, clavate shaped BiVO4 high index facets (112), (301), (200) exhibited reduced extrinsic...
Self-organized blastoids from extended pluripotent stem (EPS) cells possess enormous potential for investigating postimplantation embryo development and related diseases. However, the limited ability of EPS-blastoids hinders its further application. In this study, single-cell transcriptomic analysis indicated that "trophectoderm (TE)-like structure" was primarily composed primitive endoderm (PrE)-related instead TE-related cells. We identified PrE-like in EPS cell culture contribute to...
Abstract Background Premature ovarian failure (POF) has a profound impact on female reproductive and psychological health. In recent years, the transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) demonstrated unprecedented potential in treatment POF. However, heterogeneity human UC-MSCs remains challenge for their large-scale clinical application. Therefore, it is imperative to identify specific subpopulations within that possess capability improve function, with aim...
The METTL3-METTL14 complex, the "writer" of N6-methyladenosine (m6A), plays an important role in many biological processes. Previous studies have shown that Mettl3 overexpression can increase level m6A and promote somatic cell reprogramming. Here, we demonstrate Mettl14, another component methyltransferase significantly enhance generation induced pluripotent stem cells (iPSCs) m6A-independent manner. In cooperation with Oct4, Sox2, Klf4, c-Myc, overexpressed Mettl14 transiently promoted...
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As a semimetal, tellurium (Te) shows metallic and dielectric properties in the UV visible ranges, respectively, has potential as broad-band light absorber. In this paper, plasmonic–semiconductor hybrid nanoscale films consisting of Fe2O3 thin Te nanospheres are designed demonstrated. clusters proved to have an enhancement electric near-field broad UV–vis–NIR spectrum, which facilitates absorption charge separation photoelectrocatalysis. The thickness is adjusted from 22 137 nm. photocurrent...
Objective This study aims to understand the anxiety and depressive symptoms among front-line medical staff against COVID-19 related factors. Methods 130 from Tianyou Hospital Affiliated Wuhan University of science technology were assessed by Generalized Anxiety Disorder Scale (GAD-7), Patient Health Questionnaires (PHQ-9) scale, simple self-designed questionnaire (including 8 factors symptoms). The prevalence depression different participants according demographic characteristics...
Somatic cell nuclear transfer (SCNT) can reprogram terminally differentiated somatic cells into totipotent embryos, but with multiple defects. The nucleosome positioning, as an important epigenetic regulator for gene expression, is largely unexplored during SCNT embryonic development. Here, we mapped genome-wide profiles in mouse embryos using ultra-low-input MNase-seq (ULI-MNase-seq). We found that the nucleosome-depleted regions (NDRs) around promoters underwent dramatic reestablishment,...
Age-related functional deterioration in skeletal muscle raises the risk for falls, disability, and mortality elderly, particularly obese people or those with type 2 diabetes mellitus (T2D). However, response of to transitioning from obesity remains poorly defined, despite that is classified as a stage pre-diabetes. We screened selected spontaneously diabetic rhesus monkeys examined altered protein expression healthy aging (CON), (OB), (T2D) using Tandem Mass Tags (TMT)-based quantitative...
Objectives Although inter-arm blood pressure difference (IAD) and inter-ankle (IAND) have been shown to be associated with cardiovascular disease, controversy remains. In this study, we investigated the prevalence of IAD IAND as well correlation arterial stiffness systolic in a large number Chinese population.Methods The four-limb pressure, IAD, IAND, brachial-ankle pulse wave velocity (baPWV) ankle-brachial index (ABI) 12,176 participants measured. Multivariate logistic regression analysis...
Abstract N 6 -methyladenosine (m A) and its regulatory components play critical roles in various developmental processes mammals( 1-5 ). However, the landscape function of m A maternal-to-zygotic transition (MZT) remain unclear due to limited materials. Here, by developing an ultralow-input MeRIP-seq method, we revealed dynamics RNA methylome during MZT process mice. We found that more than 1/3 maternal decay 2/3 zygotic mRNAs were modified A. Moreover, As are highly enriched transposable...