A5100354137- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Trace Elements in Health
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Polysaccharides and Plant Cell Walls
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genomics and Rare Diseases
- Fibroblast Growth Factor Research
- DNA Repair Mechanisms
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- Sexual Differentiation and Disorders
- Cancer Research and Treatments
- Hippo pathway signaling and YAP/TAZ
- Genetic Syndromes and Imprinting
- Kruppel-like factors research
- Histone Deacetylase Inhibitors Research
Chinese Academy of Sciences
1994-2024
Northeast Agricultural University
2024
Institute of Tibetan Plateau Research
2023-2024
Peking University
2017-2024
Renji Hospital
2022-2023
Shanghai Jiao Tong University
2019-2023
Northwest Institute of Plateau Biology
2023
University of Chinese Academy of Sciences
2013-2023
Chinese People's Armed Police Force
2023
Chinese People's Armed Police General Hospital
2023
Abstract Single-cell Hi-C (scHi-C) analysis has been increasingly used to map chromatin architecture in diverse tissue contexts, but computational tools define loops at high resolution from scHi-C data are still lacking. Here, we describe Single-Nucleus Analysis Pipeline for (SnapHiC), a method that can identify and accuracy data. Using 742 mouse embryonic stem cells, benchmark SnapHiC against number of developed mapping interactions bulk Hi-C. We further demonstrate its use by analyzing...
Major evolutionary transitions are enigmas, and the most notable enigma is between invertebrates vertebrates, with numerous spectacular innovations. To search for molecular connections involved, we asked whether global epigenetic changes may offer a clue by surveying inheritance reprogramming of parental DNA methylation across metazoans. We focused on gametes early embryos, where methylomes known to evolve divergently fish mammals. Here, find that methylome during embryogenesis occurs...
Osteoporosis (OP) is closely associated with gut microbiota (GM), yet the nature of their causal relationship remains elusive. Therefore, this study aims to reverse causality between GM and OP by using population cohorts two-sample MR (TSMR) analysis.
DNA methylation plays important roles during development. However, the reprogramming of functional elements has not been fully investigated mammalian embryonic Herein, using our modified MethylC-Seq library generation method and published post-bisulphite adapter-tagging (PBAT) method, we generated genome-wide methylomes human gametes early embryos at single-base resolution compared them with mouse methylomes. We showed that dynamics in are conserved between humans mice embryogenesis, except...
The de novo differentiation of hyperplastic adipocytes from adipocyte progenitor cells (APCs) is accompanied by a reduction in adipose tissue fibrosis and inflammation improvement insulin sensitivity obesity aging. However, the regulators APC proliferation are poorly understood. Here, we show that fibroblast growth factor 6 (FGF6) acts an autocrine and/or paracrine manner to control platelet-derived receptor α–positive via extracellular signal–regulated kinase (ERK) signaling. Specific FGF6...
Abstract Purpose: Metallothionein 2A (MT2A) suppresses the progression of human gastric cancer potentially through an “MT2A–NF-κB pathway” with unclear mechanisms. This study explored role a transcription factor, myeloid zinc-finger 1 (MZF1), in MT2A-NF-κB pathway and its clinical significance cancer. Experimental Design: MZF1 expression function were investigated vitro vivo. The relationship between MT2A was determined by gain-of-function loss-of-function assays cells immortalized cell line...
Tropine and pseudotropine with opposite stereospecific configurations as platform compounds are central building blocks in both biosynthesis chemical synthesis of pharmacologically important tropane nortropane alkaloids. The supply plant-derived tropine still heavily depends on either plant extraction or synthesis. Advances synthetic biology prompt the microbial various valuable chemicals. With biosynthetic pathway elucidation several Solanaceae plants, key genes were sequentially...
Anthrax toxin receptor 1 (ANTXR1), a type I transmembrane protein, is one of the receptors that facilitates entrance anthrax into cells. Previous studies have confirmed pivotal role ANTXR1 in progression and tumorigenesis diverse cancer types. However, biological function gastric (GC) still unknown. The present study aimed to investigate GC illuminate potential molecular mechanisms. Bioinformatics analysis found expression was significantly upregulated tissue its overexpression associated...
DNA Methylation is a significant epigenetic modification that can modulate chromosome states, but its role in orchestrating organization has not been well elucidated. Here we systematically assessed the effects of on with multi-omics strategy to capture and high-order interaction simultaneously mouse embryonic stem cells methylation dioxygenase Tet triple knock-out (Tet-TKO). Globally, upon Tet-TKO, observed weakened compartmentalization, corresponding decreased differences between CpG...
Single-nucleotide polymorphisms (SNPs) of TERT-rs2736098 (C > T) and CLPTM1L-rs401681(C at the 5p15.33 locus are significantly associated with cancer risk as reported in genome-wide association studies (GWAS), but there no for squamous cell carcinoma head neck (SCCHN). In a case-control study 1079 SCCHN cases 1115 cancer-free controls non-Hispanic whites who were frequency matched by age sex, we genotyped these two SNPs assessed their associations risk. Compared CC genotypes each...
Abstract Background tRNA-derived fragments (tRFs) are newly discovered noncoding RNAs and regulate tumor progression via diverse molecular mechanisms. However, the expression biofunction of tRFs in gallbladder cancer (GBC) have not been reported yet. Methods The GBC was detected by tRF tiRNA sequencing tissues adjacent tissues. biological function investigated cell proliferation assay, clonal formation cycle xenotransplantation model lines. mechanism verified transcriptome sequencing,...
Prostate cancer (PCa) severely affects men's health worldwide. The mechanism of methyltransferase-like 3 (METTL3) in affecting PCa development by regulating miR-148a-3p expression via N6-methyladenosine (m6A) modification was investigated.METTL3, miR-148a-3p, and thioredoxin interacting protein (TXNIP) levels were determined using RT-qPCR Western blotting. m6A level observed Me-RIP assay. Bioinformatics website predicted TXNIP their correlation, the binding site between them verified...