A5015545603- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- Trace Elements in Health
- RNA modifications and cancer
- MicroRNA in disease regulation
- Garlic and Onion Studies
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Mycobacterium research and diagnosis
- NF-κB Signaling Pathways
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Drug Transport and Resistance Mechanisms
- Colorectal Cancer Screening and Detection
- ATP Synthase and ATPases Research
- RNA regulation and disease
- High Altitude and Hypoxia
- Histone Deacetylase Inhibitors Research
- Crystallization and Solubility Studies
- Cancer-related gene regulation
- Chemotherapy-induced organ toxicity mitigation
Beijing Chest Hospital
2021-2025
Capital Medical University
2022-2025
Chinese PLA General Hospital
2014-2023
Chinese People's Liberation Army
2013-2022
Cancer Research Center
2022
National Center for Nanoscience and Technology
2014-2020
Baotou Central Hospital
2017-2020
Peking University
2007-2020
Peking University Cancer Hospital
2013-2020
Zhejiang University
2020
STAT3 signaling plays the pivotal role in tumorigenesis through EZH2 epigenetic modification, which enhanced activity by increased tyrosine phosphorylation of STAT3. Here, another possible feedback mechanism and clinical significance were investigated gastric cancer (GC). STAT3, p-STAT3 (Tyr 705) expression examined 63 GC specimens with matched normal tissues IHC staining. also identified five cell lines using RT-PCR western blot analyses. protein was detected blotting. In order to...
Carrier-free pure nanodrugs (PNDs) that are composed entirely of pharmaceutically active molecules regarded as promising candidates to be the next generation drug formulations and mainly formulated from supramolecular self-assembly molecules. It benefits efficient use compounds with poor aqueous solubility takes advantage nanoscale delivery systems. Here, a type all-in-one nanoparticle consisting multiple drugs enhanced synergistic antiproliferation efficiency against drug-resistant cancer...
We are interested in developing systems for simultaneous delivery of two or more chemotherapeutic agents. Simple physical mixing drugs may reduce the therapeutic effect and cause unexpected even dangerous side-effects. For example, when 10-hydroxycamptothecin (HCPT) doxorubicin (DOX) injection solutions mixed, curative is actually reduced clinical practice. In this study we demonstrated that HCPT DOX combined into a single nanoparticle, their toxicity to tumor cells vitro synergistically...
Abstract Background Increasing evidence suggests that cancer is a metabolic disease. Here, we investigated the potential role of fructose-1,6-bisphosphatase-2 (FBP2), enzyme catalyses hydrolysis fructose-1,6-bisphosphate to fructose-6-phosphate and inorganic phosphate in glucose metabolism, gastric (GC) development. Results Our data indicated FBP2 was downregulated GC tissues (86.2%, 100/116), absent or low expression correlated with poor survival patients ( P = 0.019). Conversely, ectopic...
The treatment of pancreatic cancer frequently fails due to local recurrence and hepatic metastasis. Our previous study found that Gd@C82(OH)22 can suppress by inhibiting MMP-2/9 expression. In this study, we further explored the epigenetic mechanism in human suppressed tumor metastasis through down-regulation metastasis-associated protein 1 (MTA1), HDAC1, HIF-1α, up-regulation reversion-cysteine with Kazal motif (RECK). level acetylation was increased promoter region RECK gene after...
Recent studies have demonstrated that dysbiosis of the gut microbiota is associated with psoriasis, but these showed some conflicting results. Our study examined differences in microbiome composition people psoriasis and those without. Comparing individuals their healthy partners was a second strategy. We explored fecal among 32 nontreated plaque patients, 15 controls 17 couples by metagenomic gene sequencing. The relative levels intestinal cohort differed from patients' partners. However,...
Other| June 01, 1995 Al K-edge XANES spectra of aluminosilicate minerals Dien Li; Li University Western Ontario, Department Chemistry, London, ON, Canada Search for other works by this author on: GSW Google Scholar G. M. Bancroft; Bancroft E. Fleet; Fleet X. H. Feng; Feng Y. Pan American Mineralogist (1995) 80 (5-6): 432–440. https://doi.org/10.2138/am-1995-5-602 Article history first online: 02 Mar 2017 Cite View This Citation Add to Manager Share Icon Twitter LinkedIn Tools Get Permissions...
Metallothionein 2A (MT2A) and nuclear factor-kappaB (NF-κB) are both involved in carcinogenesis cancer chemosensitivity. We previously showed decreased expression of MT2A IκB-α human gastric (GC) associated with poor prognosis GC patients. The present study investigated the effect diallyl trisulfide (DATS), a garlic-derived compound, docetaxel (DOC) on regulation relation to NF-κB cells.DATS attenuated signaling cells, resulting G2/M cell cycle arrest apoptosis, culminating inhibition...
Abstract Background Metallothionein 2A (MT2A) as a stress protein, plays protective role in gastric mucosal barrier. Its the development of cancer (GC) is unclear. The mechanism MT2A will be investigated tumorigenesis. Methods expression was detected 973 specimens. biological function determined through ectopic expressing vitro and vivo . possible downstream effectors were NF-κB signaling. protein levels MT2A, IκB-α p-IκB-α (ser32/36) analyzed subset 258 patients by IHC staining. prognostic...
Mitochondrial genes are involved in the tumor metabolism of ovarian cancer (OC), affecting immune cell infiltration and treatment response. We aimed to utilize mitochondrial predict OC prognosis immunotherapy The data, efficacy next generation sequencing data patients were downloaded from Cancer Genome Atlas Program (TCGA) Gene Expression Omnibus (GEO). sourced MitoCarta3.0 database. Seventy percent randomly selected as discovery cohort for model construction, while remaining 30% constituted...
ABSTRACT Kaposi's sarcoma‐associated herpesvirus (KSHV) has been demonstrated to trigger a variety of malignant neoplasms, however, there are currently no targeted pharmaceutical interventions available. MicroRNA(miRNA)‐based antiviral and tumor therapies frequently utilized, yet the challenges cellular uptake susceptibility degradation underscore necessity for delivery system that can effectively combat KSHV. Nonetheless, despite efficacy nanocarriers in delivering drugs into cells, they...
Copy number variation (CNV) and abnormal expression of microRNAs (miRNAs) always lead to deregulation genes in cancer, including gastric cancer (GC). However, little is known about how CNVs affect the miRNAs. By integrating CNV miRNA profiles same samples, we identified eight miRNAs (miR-1274a, miR-196b, miR-4298, miR-181c, miR-181d, miR-23a, miR-27a miR-24-2) that were located amplified regions upregulated GC. In particular, amplification miR-23a-27a-24-2 cluster miR-181c-181d frequently...
Abstract Purpose: Metallothionein 2A (MT2A) suppresses the progression of human gastric cancer potentially through an “MT2A–NF-κB pathway” with unclear mechanisms. This study explored role a transcription factor, myeloid zinc-finger 1 (MZF1), in MT2A-NF-κB pathway and its clinical significance cancer. Experimental Design: MZF1 expression function were investigated vitro vivo. The relationship between MT2A was determined by gain-of-function loss-of-function assays cells immortalized cell line...
Abstract S100A14 is a calcium-binding protein involved in cell proliferation and differentiation as well the metastasis of human tumors. In this study, we characterized regulation expression between biological signatures clinical pathological features gastric cancer (GC). Our data demonstrated that induced GC by upregulating E-cadherin PGII. Moreover, negatively correlated with migration invasion vitro vivo experimental models. Interestingly, blocked store-operated Ca 2+ influx suppressing...
Introduction Colorectal cancer (CRC) is the third most common cancer. Precise prediction of CRC patients’ overall survival (OS) probability could offer advice on its treatment. Neural network (NN) first-class algorithm, but a consensus which NN models are better has not been established yet. A predictive model using Asian data also lacking. Material and methods We conducted 8 (n = 416) with different theories compared them data. Results DeepSurv performed best C-index value 0.8300 in...
Introduction Helicobacter pylori (H.pylori, Hp) affects billions of people worldwide. However, the emerging resistance Hp to antibiotics challenges effectiveness current treatments. Investigating genotype-phenotype connection for using next-generation sequencing could enhance our understanding this resistance. Methods In study, we analyzed 52 strains collected from various hospitals. The susceptibility these five was assessed agar dilution assay. Whole-genome then performed screen...
Colonoscopy screening has been accepted broadly to evaluate the risk and incidence of colorectal cancer (CRC) during health examination in outpatients. However, intrusiveness, complexity discomfort colonoscopy may limit its application compliance patients. Thus, more reliable convenient diagnostic methods are necessary for CRC screening. Genome instability, especially copy-number variation (CNV), is a hallmark proved have potential clinical application.We determined chromosomal CNV at arm...
Glioma is the primary malignant brain tumor with poor prognosis. Berberine (BBR) was potential drug for anti-tumor in glioma cells. Based on its limitation of aqueous solubility and instability, little information BBR nanoparticles reported glioma.Different solutions including 5% glucose, 1*PBS, ddH2O, 0.9% NaCl, cell culture medium were selected, only glucose ddH2O exhibited BBR-related nanoparticles. After heating a longer time or adding higher concentration solution, detected by TEM...
We aimed to investigate the effects of miR-34a-5p on c-fos regulation mediating malignant behaviors SH-SY5Y cells infected with Kaposi's sarcoma-associated herpesvirus (KSHV).The KSHV-infected (SK-RG) and uninfected parent were compared for differentially expressed miRNAs using transcriptome sequencing. Then was upregulated in SK-RG by miRNA mimics transfection. Cell proliferation ability determined MTT plate clone assays. The cell cycle assessed flow cytometry analysis, CDK4, CDK6, cyclin...
Abstract Few studies have provided data on the metabolomics characteristics of metabolic diseases such as hyperuricemia and hyperbilirubinemia in Tibetan plateau. In current study, we sought to investigate serum plateau, with aim provide a basis for further research their pathogenesis, prevention, treatment. The study participants were born low-altitude areas below 1000 m had no prior experience living high-altitude area before entering Golmud, Tibet (average elevation: 3000 m) Yushu,...
HPV16 E6 interacts with and degrades tumour suppressor protein TSC2 leading to the phosphorylation of p70 S6 kinase. We studied association kinase infection in cervical cancer esophageal cancer. Immunohistochemistry was used assess phosphorylated (Thr 389) (Ser235/236) 140 161 specimens. Immunohistochemical staining for pS6 significantly more frequent HPV16-infected specimens than HPV16-negative In contrast, expression similar both HPV16-positive -negative samples. The Akt, key regulator...