A5100701034- Cancer-related molecular mechanisms research
- Prion Diseases and Protein Misfolding
- Cancer Research and Treatments
- Adenosine and Purinergic Signaling
- Extracellular vesicles in disease
- Fluorine in Organic Chemistry
- Virus-based gene therapy research
- Radical Photochemical Reactions
- Cancer-related Molecular Pathways
- Eicosanoids and Hypertension Pharmacology
- Safety and Risk Management
- Cyclopropane Reaction Mechanisms
- Microbial Metabolic Engineering and Bioproduction
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Enzyme Catalysis and Immobilization
- Evaluation Methods in Various Fields
- Geoscience and Mining Technology
- Inflammatory Myopathies and Dermatomyositis
- Circular RNAs in diseases
- Systemic Sclerosis and Related Diseases
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Metabolism, Diabetes, and Cancer
Nanchang University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
China-Japan Friendship Hospital
2024
Central South University
2021-2024
Third Affiliated Hospital of Harbin Medical University
2023-2024
Harbin Medical University
2023-2024
Third Xiangya Hospital
2021-2024
Peking University People's Hospital
2003-2023
Peking University
2003-2023
Wenzhou Medical University
2022
Abstract Background Hylurgus ligniperda , a major international forestry quarantine pest, was recently found to have invaded and posed serious threat the Pinus forests of Jiaodong Peninsula in China. Continuous monitoring vigilance early population is imperative, rapid molecular detection technology urgently needed. We focused on developing single-gene-based species-specific PCR (SS-PCR) method. Results sequenced assembled mitochondrial genome H. identify suitable target genes. identified...
Abstract Cancer stem cells are implicated in tumor progression, metastasis, and recurrence, although the exact mechanisms remain poorly understood. Here, we show that expression of cellular prion protein (PrPc, PRNP) is positively correlated with an increased risk metastasis colorectal cancer. PrPc defines a subpopulation CD44-positive cancer contributes to metastatic capacity. PrPc+CD44+ displayed high liver capability, unlike PrPc−CD44+ cells, was inhibited by RNAi-mediated attenuation...
Difluoromethyl amino acids (DFAA) exhibit intriguing biological properties, making them highly desirable motifs in agrochemical and pharmaceutical science. However, stereochemical control of direct difluoromethyl transformation via the difluorocarbene species has not been demonstrated. Here we describe an efficient copper-catalyzed asymmetric difluoromethylation reaction that systematically delivers chiral DFAA as rationally designed mechanism-based inhibitors PLP-dependent acid...
Breast cancer is the most common affecting women across world. Tumor endothelial cells (TECs) and malignant are major constituents of tumor microenvironment (TME), but their origin role in shaping disease initiation, progression, treatment responses remain unclear due to significant heterogeneity.Tissue samples were collected from eight patients presenting with breast cancer. Single-cell RNA sequencing (scRNA-seq) analysis was employed investigate presence distinct cell subsets...
We present a highly efficient and versatile nickel-catalyzed protocol for the reductive cross-coupling of unactivated CF2H-substituted electrophiles with wide variety aryl alkenyl halides. This novel approach offers high catalytic reactivity broad functional group compatibility, enabling late-stage fluoroalkylation drug molecules.
The advancement of Spatial Transcriptomics (ST) has facilitated the spatially-aware profiling gene expressions based on histopathology images. Although ST data offers valuable insights into micro-environment tumors, its acquisition cost remains expensive. Therefore, directly predicting from digital pathology images is desired. Current methods usually adopt existing regression backbones along with patch-sampling for this task, which ignores inherent multi-scale information embedded in...
Abstract S100A14 is a calcium-binding protein involved in cell proliferation and differentiation as well the metastasis of human tumors. In this study, we characterized regulation expression between biological signatures clinical pathological features gastric cancer (GC). Our data demonstrated that induced GC by upregulating E-cadherin PGII. Moreover, negatively correlated with migration invasion vitro vivo experimental models. Interestingly, blocked store-operated Ca 2+ influx suppressing...
BACKGROUNDGastric cancer (GC) is one of the most aggressive malignancies, with a high incidence and poor prognosis worldwide.Recently, accumulating evidence has illustrated that long noncoding RNAs (lncRNAs) play pivotal roles in many cancers.It been reported LINC00511 contributes to tumorigenesis various diseases.However, role GC cell growth remains mostly unknown. AIMTo determine whether lncRNA exerted its carcinogenic function via miR-124-3p/PDK4 axis. METHODSCell culture transfection,...
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTApplication of NAD(P)H Model Hantzsch 1,4-Dihydropyridine as a Mild Reducing Agent in Preparation Cyclo CompoundsXiao-Qing Zhu, Hong-Yi Wang, Jian-Shuang and You-Cheng LiuView Author Information Department Chemistry, National Key Laboratory Elemento-Organic Nankai University, Tianjin 300071, Chemistry Applied Organic Lanzhou 730000, University Science Technology China, Hefei 230026, China [email protected]Cite this: J. Org. Chem. 2001, 66, 1,...
Chiral fluorinated amino esters and pyrrolidines are privileged scaffolds in synthetic chemistry exhibit unique biological properties. We report the facile preparation of these compounds through copper-catalyzed switchable defluoroalkylation [3 + 2] cycloaddition trifluoropropene an asymmetric fashion. The choice solvent chiral ligand was crucial for efficient transformation exquisite chemoselectivity pattern from identical starting materials that rapidly reliably incorporate...
Elevation of glycolysis, increase in lactic acid production, and enhancement mitochondrial biogenesis are all the changes energy metabolism melanoma cells. Melanoma cells' production networks play an important role cancer proliferation, survival, motility, invasiveness, metastasis, angiogenesis. Since Warburg theory was put forward 1930s, more researchers focus on finding new ways for effectively eliminating cells by targeting their metabolism. In this study, we found naringin has inhibitory...
Liver is the most common organ of colorectal cancer (CRC) metastasis, and hepatic metastasis (HM) regulated by complex protein network. Hence, we initiated a proteomic survey to seek interrelated multiplex markers related with HM. A total 34 unique differential proteins were identified in primary tumor tissues from 14 CRC patients with/without cluster, consisting 17 throughout PI3K/AKT pathway, was deduced validated Western blot. three-protein signature elicited phosphorylated IκBα, TNFα...
Chiral vicinal amino alcohols were generated with excellent stereoselectivity and high conversion from bulky α-amino β-keto esters by an engineered ketoreductase called M30.
The aims of the study were to identify differentially expressed genes (DEGs) between primary melanomas and metastasis (MMs), investigate mechanisms MMs. microarray data GSE8401 including 31 52 MMs downloaded from Gene Expression Omnibus. DEGs identified using Linear Models for Microarray Data package. functional pathway enrichment analyses performed DEGs. Identification transcription factors, tumor-associated (TAGs), tumor suppressor (TSGs) with TRANSFAC, TAG, TSGene databases, respectively....
(S)-2-Chloro-1-(2,4-dichlorophenyl) ethanol (3) is a chiral intermediate in the synthesis of luliconazole ((R)-E-1). Here, we report novel biopreparation 3 by bioreduction 2-chloro-1-(2,4-dichlorophenyl) ethanone (2) using recombinant Escherichia coli expressing LK08, ketoreductase mutant from Lactobacillus kefiri, as biocatalyst. The reaction conditions for biotransformation including pH, temperature, and concentration isopropanol NADP+, well amount E. cells, were optimized to improve...
Long non-coding RNA (lncRNA) TP53 target 1 (TP53TG1) is known to be strongly associated with tumor and cancer progression. However, its expression profile, unique role, regulatory pathways in retinoblastoma (RB) are not known. Here, we revealed a large of TP53TG1 RB tissues cell lines. Conversely, showed marked suppression proliferation, migration, invasion knocked down cells. Mechanistically, established that directly interacted microRNA (miR)-33b Furthermore, transcripts were found...
Abstract Many people affected by fragile X syndrome (FXS) and autism spectrum disorders have sensory processing deficits, such as hypersensitivity to auditory, tactile, visual stimuli. Like FXS in humans, loss of Fmr1 rodents also cause sensory, behavioral, cognitive deficits. However, the neural mechanisms underlying impairment, especially vision remain unclear. It remains elusive whether deficits originate from corrupted inputs, impaired perception primary cortex, or altered integration...
Tumor-derived extracellular vesicles (EVs) are potential biomarkers for tumors, but their reliable molecular targets have not been identified. The previous study confirms that ubiquitin-specific protease 22 (USP22) promotes lung adenocarcinoma (LUAD) metastasis in vivo and vitro. Moreover, USP22 regulates endocytosis of tumor cells localizes to late endosomes. However, the role secretion cell-derived EVs remains unknown. In this study, it demonstrates increases accelerates migration...
Lung adenocarcinoma is the most common type of lung cancer, accounting for approximately 40% all cancer cases, and has highest incidence among subtypes. Recent studies have suggested that long non-coding RNAs (lncRNAs) play a crucial role in initiation progression adenocarcinoma.
Due to its double bond, istradefylline rapidly isomerizes
The saponin monomer 13 of dwarf lilyturf tuber (DT-13), one the monomers tuber, has been found to have potent cardioprotective effects. In order investigate effect DT-13 on L-type calcium currents ( I Ca,L ), exploring mechanisms DT-13's effects, we directly measured in adult rat cardiac myocytes exposed using standard whole-cell patch-clamp recording technique. Our results showed that exerted inhibitory effects single myocytes. current density was reduced by about 38% after exposure cells...
The drug response sensitivity and related prognosis of prostate cancer varied from races, while the original mechanism remains rarely understood. In this study, comprehensive signature including transcriptomics, epigenome single nucleotide polymorphisms (SNPs) 485 PCa cases- 415 Whites, 58 Blacks 12 Asians TCGA database were analyzed to investigate metabolism differences between races. We found that Whites had a more prominent metabolism, cytotoxic therapy resistance, endocrine resistance...