A5054278485- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Neural dynamics and brain function
- Lipid Membrane Structure and Behavior
- Sirtuins and Resveratrol in Medicine
- Neuroendocrine regulation and behavior
- Cellular transport and secretion
- Trigeminal Neuralgia and Treatments
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Stress Responses and Cortisol
- Genetics and Neurodevelopmental Disorders
- Connexins and lens biology
- Sleep and related disorders
- Genetic Syndromes and Imprinting
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- RNA regulation and disease
Anhui Medical University
2015-2025
Queen's University Belfast
2024
Shandong University
2016
Chinese Institute for Brain Research
2013-2015
Peking University
2005-2015
Center for Life Sciences
2013-2015
Zhejiang University
2012
Northeast Ohio Medical University
2011
Stomatology Hospital
2008
Shanghai Institutes for Biological Sciences
2004-2006
Under physiological conditions, astrocytes not only passively support and nourish adjacent neurons, but also actively modulate neuronal transmission by releasing “glial transmitters,” such as glutamate, ATP, d -serine. Unlike the case for mechanisms which glia release transmitters are essentially unknown. Here, using electrochemical amperometry frequency-modulated single-vesicle imaging, we discovered that hippocampal exhibit two modes of exocytosis glutamate in response to various stimuli....
Voltage-gated sodium channels (VGSCs), especially the tetrodotoxin-sensitive Nav1.3 and Nav1.7, tetrodotoxin-resistant Nav1.8 Nav1.9, have been implicated in acute chronic neuropathic pain. The aim of this study was to investigate expression VGSC Nav1.3, Nav1.8, Nav1.9 after nerve injury their roles development trigeminal neuralgia (TN). We used infraorbital nerve-chronic constriction model TN rat. time course changes mechanical pain threshold examined. In addition, real-time PCR double...
Abstract Kruppel-like factor 15 (KLF15), a member of the KLF family, is closely involved in many biological processes. However, mechanism by which KLF15 regulates neural development still unclear. Considering complexity and importance network development, this study, we investigated potent regulatory role development. was detected highly expressed cerebellum enriched Purkinje cells, with significant increase expression between 20 days Knockdown led to loss cells impaired motility mice....
Nav1.3 is a tetrodotoxin-sensitive voltage-gated sodium channel isoform encoded by SCN3A, the abnormal expression of which plays crucial role in generation ectopic discharge, as well being associated with allodynia and hyperalgesia. Using bioinformatics analysis, we showed that miR-30b-5p directly targets SCN3A. We aimed to explore whether can participate trigeminal neuralgia (TN) rats regulating Nav1.3. The rat TN model was constructed through infraorbital nerve-chronic constriction injury...
High-salt intake is a major risk factor in the development of hypertension. The underlying mechanism high sodium on cardiovascular system has received extensive attention. TRPP2 (Polycystin-2) Ca(2+) permeable nonselective cation channel that mediates mobilization to control vascular smooth muscle cells (VSMCs) contraction. Here, we investigated expression change VSMCs from high-salt hypertensive rats and role diet-induced hypertension.After 4 ws dietary treatment, systolic blood pressure...
Highlights•Two-photon imaging enables the monitoring of neural activities on behaving animals•A neuronal subpopulation in mPFC that exhibited emergent properties encodes STM•These subpopulations exclusively comprise excitatory neurons•This STM coding mechanism is absent an animal model ADSummaryShort-term memory (STM) crucial for animals to hold information a small period time. Persistent or recurrent activity, together with oscillations, known encode at cellular level. However, mechanisms...
Pain is a multidimensional perception that includes unpleasant somatosensory and affective experiences; however, the underlying neural circuits mediate different components of pain remain elusive. Although hyperactivity basolateral amygdala glutamatergic (BLAGlu) neurons required for emotional processing pain, precise excitatory inputs to BLAGlu their roles in mediating aspects are unclear. Here, we identified two discrete neuronal male mice: projection from insular cortex (ICGlu) neurons,...
Dexmedetomidine (Dex) is a highly selective α2 adrenergic agonist used in clinical anesthesia. Studies have shown that Dex can act on the collecting duct and reduce body's water reabsorption, thereby increasing discharge. However, specific mechanism of homeostasis remains unclear. The hypothalamus regulatory center salt balance secretes related neurochemical hormones, such as arginine vasopressin (AVP), to regulate discharge salt. paraventricular nucleus (PVN) supraoptic (SON) are also...
Trigeminal neuralgia (TN) is a common and difficult-to-treat neuropathic pain disorder in clinical practice. Previous studies have shown that Toll-like receptor 4 (TLR4) modulates the activation of NF-κB pathway to affect rats. Voltage-gated sodium channels (VGSCs) are known play an important role electrical activity. To investigate whether TLR4 can regulate Nav1.3 through TRAF6/NF-κB p65 after infraorbital nerve chronic constriction injury (ION-CCI). Study design: ION-CCI modeling was...
The ventrolateral preoptic nucleus (VLPO) in the anterior hypothalamus and tuberomammillary (TMN) posterior are critical regions which involve regulation of sleep-wakefulness flip-flop central nervous system. Most VLPO neurons sleep-promoting neurons, co-express γ-aminobutyric acid (GABA) galanin, while TMN express histamine (HA), a key wake-promoting neurotransmitter. Previous studies have shown that two innervated between each other, but how to regulate sleep-wake cycle not yet clear....
Trigeminal neuralgia is a common chronic maxillofacial neuropathic pain disorder, and voltage-gated sodium channels (VSGCs) are likely involved in its pathology. Prior studies report that pituitary adenylate cyclase-activating polypeptide (PACAP), neuropeptide highly expressed the trigeminal ganglion, may contribute to dorsal root ganglion neuron excitability by modulating Nav1.7.We investigated whether PACAP can regulate Nav1.7 through mitogen-activated protein kinase/ERK...
Abstract Light plays a direct crucial role in the switch between sleep and arousal regulation of physiology behaviour, such as circadian rhythms emotional change. Artificial lights, which are different from natural light sources with continuous spectrum, composed three single-colour lights increasingly applied modern society. However, vivo research on mechanisms blue light-regulated is still insufficient. In this work, we detected effects inserting white or for 1 h during dark period...
Abstract Many people affected by fragile X syndrome (FXS) and autism spectrum disorders have sensory processing deficits, such as hypersensitivity to auditory, tactile, visual stimuli. Like FXS in humans, loss of Fmr1 rodents also cause sensory, behavioral, cognitive deficits. However, the neural mechanisms underlying impairment, especially vision remain unclear. It remains elusive whether deficits originate from corrupted inputs, impaired perception primary cortex, or altered integration...
Purpose Small and medium-sized enterprises (SMEs) are critical for achieving a green economy. This study aims to empirically explore business associations’ impacts on SMEs’ transformation in China. Design/methodology/approach uses multiple-case approach. The authors collect data from four Chinese associations their members. Findings finds that promote by providing individual collective services. SMEs conduct developing mindset adopting operations. results show services directly enhance...