A5100454294- Cellular transport and secretion
- Neuroscience and Neuropharmacology Research
- Microtubule and mitosis dynamics
- Ion channel regulation and function
- Retinal Development and Disorders
- Nerve injury and regeneration
- Lipid Membrane Structure and Behavior
- Cellular Mechanics and Interactions
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Free Will and Agency
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Skin and Cellular Biology Research
- Endoplasmic Reticulum Stress and Disease
- Regulation of Appetite and Obesity
- Genetics, Aging, and Longevity in Model Organisms
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Psychology of Moral and Emotional Judgment
- Parkinson's Disease Mechanisms and Treatments
- Sleep and Work-Related Fatigue
- Calcium signaling and nucleotide metabolism
- Wnt/β-catenin signaling in development and cancer
- Advanced Electron Microscopy Techniques and Applications
Institute of Genetics and Developmental Biology
2013-2024
University of Chinese Academy of Sciences
2017-2024
Chinese Academy of Sciences
2014-2024
Institute of Psychology, Chinese Academy of Sciences
2023-2024
Center for Excellence in Brain Science and Intelligence Technology
2015-2022
Nanjing Brain Hospital
2014-2016
Nanjing Medical University
2014-2016
Air Force General Hospital PLA
2016
Jinan University
2014
Henan University of Science and Technology
2012
ABSTRACT Depressive symptoms are common in Parkinson's disease (PD), but the pathophysiology and neural basis underlying depression PD is not well understood. Abnormal functional connectivity of amygdala with various cortical subcortical areas has been observed major depressive disorder, indicating that dysfunction corticolimbic network may be involved pathogenesis disorder. However, little known about alterations depressed patients. In present study, 20 patients, 40 nondepressed 43 matched...
Depressive symptoms are common in Parkinson's disease (PD), but the neurophysiological mechanisms of depression PD poorly understood. The current study attempted to examine disrupted spontaneous local brain activities and functional connectivities that underlie PD. We recruited a total 20 depressed patients (DPD), 40 non-depressed (NDPD) 43 matched healthy controls (HC). All subjects underwent neuropsychological tests resting-state fMRI scanning. between-group differences amplitude low...
Giant axonal neuropathy (GAN), an autosomal recessive disorder caused by mutations in GAN, is characterized cytopathologically cytoskeletal abnormality. Based on its sequence, gigaxonin contains NH2-terminal BTB domain followed six kelch repeats, which are believed to be important for protein–protein interactions (Adams, J., R. Kelso, and L. Cooley. 2000. Trends Cell Biol. 10:17–24.). Here, we report the identification of a neuronal binding partner gigaxonin. Results obtained from yeast...
Rap1 transduces nerve growth factor (NGF)/tyrosine receptor kinase A (TrkA) signaling in early endosomes, leading to sustained activation of the p44/p42 mitogen-activated protein kinases (MAPK1/2). However, mechanisms by which NGF, TrkA and are trafficked endosomes poorly defined. We investigated trafficking PC12 cells cultured rat dorsal root ganglion (DRG) neurons. Herein, we show a role for both microtubule- dynein-based transport NGF through MAPK1/2. treatment resulted perinuclear region...
Abstract The endosomal trafficking pathways are essential for many cellular activities. They also important targets by intracellular pathogens. Key regulators of the include retromer complex and sorting nexins (SNXs). Chlamydia trachomatis effector protein IncE directly components SNX5 SNX6 suppresses retromer-mediated transport, but exact mechanism has remained unclear. We present crystal structure PX domain in with IncE, showing that binds to a highly conserved hydrophobic groove SNX5....
Disruption of the BPAG1 (bullous pemphigoid antigen 1) gene results in progressive deterioration motor function and devastating sensory neurodegeneration null mice. We have previously demonstrated that BPAG1n1 BPAG1n3 play important roles organizing cytoskeletal networks vivo. Here, we characterize functions a novel neuronal isoform, BPAG1n4. Results obtained from yeast two-hybrid screening, blot overlay binding assays, coimmunoprecipitations demonstrate BPAG1n4 interacts directly with...
Appropriate clearance of apoptotic cells (cell corpses) is an important step programmed cell death. Although genetic and biochemical studies have identified several genes that regulate the engulfment corpses, how these are degraded after being internalized in engulfing remains elusive. Here, we show VPS-18, Caenorhabditis elegans homologue yeast Vps18p, critical to corpse degradation. VPS-18 expressed functions cells. Deletion vps-18 leads significant accumulation corpses not properly....
Brain-derived neurotrophic factor (BDNF) binds to its cell surface receptor TrkB regulate differentiation, development, synaptic plasticity, and functional maintenance of neuronal cells. Binding BDNF triggers dimerization autophosphorylation, which provides docking sites for adaptor proteins recruit activate downstream signaling molecules. The molecular mechanisms underlying BDNF–TrkB endocytic trafficking crucial spatiotemporal control pathways remain be elucidated. Here we show that...
Abstract The alterations of interhemispheric resting-state functional connectivity (FC) in Parkinson’s disease (PD) with depression remain unclear, so we aimed to explore the differences FC between PD and without depression. Twenty-one depressed (DPD) patients, 49 non-depressed (NDPD) patients 50 matched healthy controls (HC) participated this study. Resting-state magnetic resonance imaging (fMRI) data were analyzed voxel-mirrored homotopic (VMHC) approach. DPD showed lower VMHC values...
Retrograde axonal transport plays an important role in the maintenance of neuronal functions, but mechanism is poorly defined partly because constituents retrograde system and their interactions have yet to be elucidated. Of special interest how dynein/dynactin motor proteins interact with membrane cargoes. Here, we report that endosomal vesicle protein, termed retrolinkin, functions as a receptor tethering vesicles through BPAG1n4. Retrolinkin, protein highly enriched endosomes, binds...
HPS6 was originally identified as a subunit of the BLOC-2 protein complex which is involved in biogenesis lysosome-related organelles (LRO). Here, we demonstrate that directly interacts with p150Glued dynein–dynactin motor and acts cargo adaptor for retrograde to mediate transport lysosomes from cell periphery perinuclear region. Small interference RNA (siRNA)-mediated knockdown HeLa cells not only partially blocks centripetal movement but also causes delay lysosome-mediated degradation....
Retrolinkin, a neuronal membrane protein, coordinates with endophilin A1 and mediates early endocytic trafficking signal transduction of the ligand–receptor complex formed between brain-derived neurotrophic factor (BDNF) its receptor, tropomyosin-related kinase B (TrkB), in dendrites CNS neurons. Here we report that retrolinkin interacts CYFIP1/2 subunit WAVE1 complex, member WASP/WAVE family nucleation-promoting factors binds activates Arp2/3 to promote branched actin polymerization. WAVE1,...
Induction of long-term potentiation (LTP) in excitatory neurons triggers a large transient increase the volume dendritic spines followed by decays to sustained size expansion, process termed structural LTP (sLTP) that contributes cellular basis learning and memory. Although mechanisms regulating early phases sLTP have been studied intensively, how acute spine enlargement immediately after stimulation is achieved remains elusive. Here, we report endophilin A1 orchestrates membrane dynamics...
SNX6 is a ubiquitously expressed PX-BAR protein that plays important roles in retromer-mediated retrograde vesicular transport from endosomes. Here we report CNS-specific Snx6 knockout mice exhibit deficits spatial learning and memory, accompanied with loss of spines distal dendrites hippocampal CA1 pyramidal cells. interacts Homer1b/c, postsynaptic scaffold crucial for the synaptic distribution other density (PSD) proteins structural integrity dendritic spines. We show functions...