A5075359444- Cellular transport and secretion
- Developmental Biology and Gene Regulation
- Biotin and Related Studies
- Axon Guidance and Neuronal Signaling
- Hippo pathway signaling and YAP/TAZ
- Genetics, Aging, and Longevity in Model Organisms
- Ecosystem dynamics and resilience
- Tree-ring climate responses
- Plant Molecular Biology Research
- Ubiquitin and proteasome pathways
- Supramolecular Self-Assembly in Materials
- Neurobiology and Insect Physiology Research
- Wnt/β-catenin signaling in development and cancer
- Plant Reproductive Biology
- Neuroscience and Neuropharmacology Research
- Microtubule and mitosis dynamics
- Signaling Pathways in Disease
- Endoplasmic Reticulum Stress and Disease
- Cellular Mechanics and Interactions
- Advanced Materials and Mechanics
- Synthesis of Organic Compounds
- Micro and Nano Robotics
- Geology and Paleoclimatology Research
- bioluminescence and chemiluminescence research
Stanford University
2019-2024
University of Chinese Academy of Sciences
2011-2024
Institute of Geology and Geophysics
2024
Allscripts (United States)
2023
Institute of Genetics and Developmental Biology
2008-2011
Chinese Academy of Sciences
2008-2011
One of the challenges to understand organization nervous system has been determine how axon guidance molecules govern outgrowth. Through an unbiased genetic screen, we identified a conserved Wnt pathway which is crucial for anterior-posterior (A/P) outgrowth neurites from RME head motor neurons in Caenorhabditis elegans. The composed ligand CWN-2, Frizzled receptors CFZ-2 and MIG-1, co-receptor CAM-1/Ror, downstream component Dishevelled/DSH-1. Among these, CWN-2 acts as local attractive cue...
Dendrite microtubules are polarized with minus-end-out orientation in Drosophila neurons. Nucleation sites concentrate at dendrite branch points, but how they localize is not known. Using Drosophila, we found that canonical Wnt signaling proteins regulate localization of the core nucleation protein γTubulin (γTub). Reduction frizzleds (fz), arrow (low-density lipoprotein receptor-related [LRP] 5/6), dishevelled (dsh), casein kinase Iγ, G proteins, and Axin reduced γTub-green fluorescent...
Appropriate clearance of apoptotic cells (cell corpses) is an important step programmed cell death. Although genetic and biochemical studies have identified several genes that regulate the engulfment corpses, how these are degraded after being internalized in engulfing remains elusive. Here, we show VPS-18, Caenorhabditis elegans homologue yeast Vps18p, critical to corpse degradation. VPS-18 expressed functions cells. Deletion vps-18 leads significant accumulation corpses not properly....
Subcellular asymmetry directed by the planar cell polarity (PCP) signaling pathway orients numerous morphogenetic events in both invertebrates and vertebrates. Here, we describe a movement which intertwined socket shaft cells of Drosophila anterior wing margin mechanosensory bristles undergo PCP-directed apical rotation, inducing twisting that results helical structure defined chirality. We show Frizzled/Vang PCP module coordinates among between surrounding to direct this rotation....
Planar cell polarity (PCP) signaling regulates several polarization events during development of ommatidia in the Drosophila eye, including directing chirality by polarizing a fate choice and determining direction extent ommatidial rotation. The pk sple isoform PCP protein Prickle is known to participate R3/R4 decision, but control other potential contributions three Pk isoforms have not been clarified. Here, characterizing expression subcellular localization individual together with...
The planar cell polarity (PCP) signaling pathway polarizes epithelial cells in the tissue plane by segregating distinct molecular subcomplexes to opposite sides of each cell, where they interact across intercellular junctions form asymmetric clusters. role clustering this process is unknown. We hypothesized that protein cluster size distributions could be used infer underlying dynamics and function assembly polarization. developed a method count number monomers core PCP proteins within...
PCP signaling polarizes epithelial cells within the plane of an epithelium. Core components adopt asymmetric subcellular localizations to both polarize and coordinate polarity between cells. Achieving asymmetry requires additional effectors, including some mediating post-translational modifications core components. Identification such proteins is challenging due pleiotropy. We used mass spectrometry-based proximity labeling proteomics identify regulators in Drosophila wing. identified...